Genomic and clinical characterization of Klebsiella pneumoniae carrying the pks island [PDF]
Frontiers in Microbiology, 2023 BackgroundThe pks island and its production of the bacterial secondary metabolite genotoxin, colibactin, have attracted increasing attention. However, genomic articles focusing on pks islands in Klebsiella pneumoniae, as well as comparative genomic ...
Qun Yan, Wenen Liu, Wang Zhiqian
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Escherichia coli BarA-UvrY regulates the pks island and kills Staphylococci via the genotoxin colibactin during interspecies competition. [PDF]
PLoS Pathogens, 2022 Wound infections are often polymicrobial in nature, biofilm associated and therefore tolerant to antibiotic therapy, and associated with delayed healing.
Jun Jie Wong +10 more
doaj +9 more sources
Detection of pks Island mRNAs Using Toehold Sensors in Escherichia coli [PDF]
Life, 2021 Synthetic biologists have applied biomolecular engineering approaches toward the goal of novel biological devices and have shown progress in diverse areas of medicine and biotechnology.
Taeyang Heo +3 more
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Genomic characterization of Escherichia coli with a polyketide synthase (pks) island isolated from ulcerative colitis patients [PDF]
BMC GenomicsThe E. coli strains harboring the polyketide synthase (pks) island encode the genotoxin colibactin, a secondary metabolite reported to have severe implications for human health and for the progression of colorectal cancer.
Chao Lv, Yung-Fu Chang, Chen Yiwen
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Molecular Genetic and Functional Analysis of pks-Harboring, Extra-Intestinal Pathogenic Escherichia coli From India [PDF]
Frontiers in Microbiology, 2018 Colibactin, a genotoxin, encoded by the pks pathogenicity island of Escherichia coli belonging to the B2 phylogroup has been reported as a determinant of bacterial pathogenicity. The present study was carried out to detect the pks pathogenicity island in
Arya Suresh +2 more
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Western-Style Diet, pks Island-Carrying Escherichia coli, and Colorectal Cancer: Analyses From Two Large Prospective Cohort Studies [PDF]
Gastroenterology, 2022 Evidence supports a carcinogenic role of Escherichia coli carrying the pks island that encodes enzymes for colibactin biosynthesis. We hypothesized that the association of the Western-style diet (rich in red and processed meat) with colorectal cancer incidence might be stronger for tumors containing higher amounts of pks+E coli.Western diet score was ...
Kota Arima +2 more
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Targeted depletion of pks + bacteria from a fecal microbiota using specific antibodies
MSystems, 2023 The pks island is one of the most prevalent pathogenicity islands among the Escherichia coli strains that colonize the colon of colorectal carcinoma (CRC) patients.
Aitor Blanco-Míguez +2 more
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Colibactin (pks) carriage in Escherichia coli is associated with lineage restriction, reduced plasmid burden, and lower antimicrobial resistance [PDF]
Frontiers in MicrobiologyThe colibactin pks genomic island of Escherichia coli is a chromosomally integrated secondary metabolite locus implicated in host–microbe interactions and colorectal carcinogenesis. Although pks distribution has been linked to specific E.
Adel Azour +6 more
doaj +2 more sources
Genetic and Functional Analysis of the pks Gene in Clinical Klebsiella pneumoniae Isolates
Microbiology Spectrum, 2023 The pks gene cluster encodes colibactin, which can cause DNA damage and enhance the virulence in Escherichia coli. However, the role of the pks gene in Klebsiella pneumoniae has not been fully discussed.
Yanshu Chen, Xiaoqian Liu, Bin Yang
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The synthesis of the novel Escherichia coli toxin—colibactin and its mechanisms of tumorigenesis of colorectal cancer [PDF]
Frontiers in MicrobiologyEscherichia coli is part of the normal flora of the human gut and performs vital functions; however, certain strains can cause disease in the host, impairing gut function and adversely affecting overall health. The pks gene cluster in the E.
Guojing Zhang, Daqing Sun
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