Results 161 to 170 of about 3,877 (197)

The Prognostic Value of Anti-PLA2R Antibodies Levels in Primary Membranous Nephropathy

open access: yesInternational Journal of Molecular Sciences, 2023
Anti-PLA2R antibodies (Ab) are a diagnostic and prognostic biomarker in primary membranous nephropathy (PMN). We assessed the relationship between the levels of anti-PLA2R Ab at diagnosis and different variables related to disease activity and prognosis ...
Boris Gilburd, Olga Lesya Kukuy
exaly   +2 more sources

Secretory expression and purification of recombinant PLA2R epitopes for the detection of anti-PLA2R autoantibody in serum

The Analyst, 2022
M-type phospholipase A2 receptor (PLA2R) is a significant biomarker contributing to the clinical diagnosis of idiopathic membranous nephropathy (IMN).
Xinxin Xu   +7 more
openaire   +2 more sources

Clinicopathological Characteristics and Outcomes of PLA2R-Associated Membranous Nephropathy in Seropositive Patients Without PLA2R Staining on Kidney Biopsy

American Journal of Kidney Diseases, 2022
Phospholipase A2 receptor (PLA2R)-associated membranous nephropathy (MN) with circulating serum autoantibodies to PLA2R (SAb+) but no deposits of PLA2R antigen in glomerular tissue by immunofluorescence (GAg-) has been reported. However, little is known about the clinicopathological characteristics or prognosis of this subtype of MN.Retrospective ...
Fang Yang, Jiao Luo, Jianwei Tian
exaly   +3 more sources

The Association of Serum Anti-PLA2R Antibody and Glomerular PLA2R Antigen Staining With Clinical Manifestations and Outcomes in Membranous Nephropathy

Clinical and Experimental Nephrology, 2023
Phospholipase A2 receptor (PLA2R)-associated membranous nephropathy (MN) was manifested as seropositive for PLA2R antibodies (SAb) and/or glomerular PLA2R antigens' (GAg) deposits. According to the test of SAb and GAg, PLA2R-associated MN can be divided into SAb + /GAg-, SAb-/GAg + , and SAb + /GAg + groups. The clinical characteristics and outcomes of
Ping Lan
exaly   +3 more sources

Anti-PLA2R IgG4-to-IgG Ratio Helps Predict Remission of PLA2R-Associated Primary Membranous Nephropathy

American Journal of Nephrology
Introduction: PLA2R-associated primary membranous nephropathy (PMN) was classified as IgG4-associated autoimmune disease, in which anti-PLA2R antibody is predominantly IgG4 subclass. Our objective was to explore the capability of anti-PLA2R IgG4-to-IgG ratio for predicting remission in PLA2R-associated PMN patients.
Yuting Liu   +8 more
openaire   +2 more sources

Integrated sTim-3 and PLA2R-Ab Levels Improve Risk Stratification in PLA2R-Positive Membranous Nephropathy

Nephron
Introduction: The utility of M-type phospholipase A2 receptor antibody (PLA2R-Ab) for risk stratification in membranous nephropathy (MN) remains suboptimal, while soluble T-cell immunoglobulin and mucin-domain containing-3 (sTim-3) has been confirmed as a critical immune regulator in kidney diseases. This study investigated the prognostic value of sTim-
Tianyu, Zheng   +10 more
openaire   +2 more sources

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