Results 71 to 80 of about 1,501,016 (387)

Magnetic Resonance Imaging Pilot Study of Intravenous Glyburide in Traumatic Brain Injury. [PDF]

, 2020
Pre-clinical studies of traumatic brain injury (TBI) show that glyburide reduces edema and hemorrhagic progression of contusions. We conducted a small Phase II, three-institution, randomized placebo-controlled trial of subjects with TBI to assess the ...
Aldrich, Christina, Eisenberg, Howard M, Hayman, Erik G, He, Feng, Jain, Sonia, Okonkwo, David O, Pasternak, Ofer, Shenton, Martha E, Simard, J Marc   +8 more
core  

Cognitive Resilience in Apolipoprotein ε4 Carrier Women Predicted by Neuron‐Derived Extracellular Vesicles

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Apolipoprotein (APOE) ε4 allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD); however, many ε4 carriers remain cognitively intact into old age. Leveraging plasma neuron‐derived extracellular vesicles (NDEVs), we sought to identify biomarkers of cognitive resilience and their interplay with APOE ...
Apostolos Manolopoulos, Maja Mustapic, Carlos Nogueras‐Ortiz, Francheska Delgado‐Peraza, Krishna A. Pucha, Pamela J. Yao, Joseph Blommer, Michael P. Vreones, William York, De' Larrian Knight, Stephen R. Rapp, Aladdin H. Shadyab, JoAnn E. Manson, Ramon Casanova, Robert B. Wallace, Luigi Ferrucci, Susan M. Resnick, Dimitrios Kapogiannis   +17 more
wiley   +1 more source

Development and Psychometric Evaluation of the Hope in Medicine Scale

Clinical Psychology in Europe
[Background] Hope is an integral, multi-dimensional part of seeking medical treatment. The aim of this study was to develop a self-report scale, the Hope in Medicine (HIM) scale, to measure different modes of hoping in relation to the course of symptoms,
Lea Balthasar, Anne-Kathrin Bräscher, Ted J. Kaptchuk, Sarah K. Ballou, Tobias Kube   +4 more
doaj   +1 more source

Mechanisms of Perceived Treatment Assignment and Subsequent Expectancy Effects in a Double Blind Placebo Controlled RCT of Major Depression

Frontiers in Psychiatry, 2018
Objective: It has been suggested that patients' perception of treatment assignment might serve to bias results of double blind randomized controlled trials (RCT).
Johannes A. C. Laferton, Johannes A. C. Laferton, Johannes A. C. Laferton, Sagar Vijapura, Lee Baer, Alisabet J. Clain, Abigail Cooper, George Papakostas, Lawrence H. Price, Linda L. Carpenter, Audrey R. Tyrka, Maurizio Fava, David Mischoulon   +12 more
doaj   +1 more source

Glucose and cognitive performance : the effects of glucose on memory and sustained attention : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Psychology at Massey University [PDF]

, 2004
The effects of glucose on tasks of declarative memory, and sustained attention were examined. These effects were also investigated with regard to the age of the participant.
Richardson, Kelly
core  

Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety [PDF]

, 2010
<p>Background: Melatonin is extensively used in the USA in a non-regulated manner for sleep disorders. Prolonged release melatonin (PRM) is licensed in Europe and other countries for the short term treatment of primary insomnia in patients aged 55 ...
A Brzezinski, A Chesson, AG Wade, AJ Lewy, Alan G Wade, Alex McConnachie, C Cajochen, C Liu, CA Czeisler, D Buysse, D Garfinkel, D Leger, DJ Buysse, DJ Kennaway, E Grossman, EM Gibson, G Hajak, G Mayer, Gordon Crawford, H Nakagawa, HJ Lynch, I Haimov, I Haimov, Ian Ford, IV Zhdanova, J Backhaus, JG MacFarlane, JK Wyatt, M Littner, M Littner, M Sharma, MA Hofman, MA Paul, Moshe Laudon, N Buscemi, N Zisapel, Nava Zisapel, OL Bech P, P Lemoine, P Tyrer, R Luthringer, R Mahlberg, R Mahlberg, S Ancoli-Israel, SW Lockley, T Gorfine, T Gorfine, T Roth, T Shochat, Tali Nir, W Guy, World Psychiatric Association, YH Wu   +52 more
core   +3 more sources

Effects of Pharmacologic and Nonpharmacologic Interventions for the Management of Sleep Problems in People With Fibromyalgia: Systematic Review and Network Meta‐Analysis of Randomized Controlled Trials

Arthritis Care &Research, EarlyView.
Objective Fibromyalgia is a chronic condition characterized by widespread musculoskeletal pain and fatigue. Almost everyone with fibromyalgia has sleep problems. We aimed to evaluate the effectiveness and safety of current interventions for the management of fibromyalgia‐related sleep problems.
Jemma Hudson, Mari Imamura, Clare Robertson, Daniel Whibley, Lorna Aucott, Katie Gillies, Paul Manson, Debra Dulake, Abhishek Abhishek, Nicole K. Y. Tang, Gary J. Macfarlane, Miriam Brazzelli   +11 more
wiley   +1 more source

Hormone Replacement Therapy and Menopause: A Review of Randomized, Double-Blind, Placebo-Controlled Trials

Kaohsiung Journal of Medical Sciences, 2003
Hormone replacement therapy (HRT) is frequently prescribed to healthy women to ameliorate menopausal symptoms. HRT is used long term (≥ 1 year) to prevent chronic disease in older women. The objective of this study was to review the benefits and risks of
Chueh Chang
doaj   +1 more source

Withdrawal from treatment as an outcome in the Isolde study of COPD [PDF]

, 2003
Objectives: To investigate the determinants of patient withdrawal from our study, and the effect of these withdrawals on the outcome of treatment with inhaled corticosteroids in patients with COPD.
American Thoracic Society, Brazier, Burge, Chervinsky, Davies, Greening, Jarad, Jones, Jones, Jones, Jones, Lisa Willits, Meecham-Jones, Nelson, Niewoehner, Osman, P. Sherwood Burge, Paul W. Jones, Pauwels, Pauwels, Pauwels, Peter M.A. Calverley, Sally Spencer, Seemungal, Spencer, The Lung Health Study Research Group, Vestbo, Ware   +27 more
core   +1 more source

A Placebo‐Controlled Trial of Bezafibrate in Primary Biliary Cholangitis

New England Journal of Medicine, 2018
Background Patients with primary biliary cholangitis who have an inadequate response to therapy with ursodeoxycholic acid are at high risk for disease progression.
C. Corpechot, O. Chazouilleres, A. Rousseau, Antonia Le Gruyer, F. Habersetzer, P. Mathurin, O. Goria, P. Potier, A. Minello, C. Silvain, A. Abergel, M. Debette‐Gratien, D. Larrey, O. Roux, J. Bronowicki, J. Boursier, V. de Lédinghen, A. Heurgue-berlot, E. Nguyen-Khac, F. Zoulim, I. Ollivier-Hourmand, J. Zarski, G. Nkontchou, S. Lemoinne, L. Humbert, D. Rainteau, G. Lefèvre, L. de Chaisemartin, S. Chollet-Martin, F. Gaouar, Farid-Hakeem Admane, T. Simon, R. Poupon   +32 more
semanticscholar   +1 more source