Intestinal antimicrobial gene expression: impact of micronutrients in malnourished adults during a randomized trial. [PDF]
, 2010 BACKGROUND: Because both micronutrients and antimicrobial peptides protect against diarrhea, we looked for an effect on intestinal antimicrobial peptide gene expression during a randomized controlled trial of multiple micronutrient (MM) supplementation ...
Bevins, Charles L +8 more
core +1 more source
A randomized placebo-controlled pilot study of the efficacy and safety of D-cycloserine in people with chronic back pain. [PDF]
, 2016 BACKGROUND: Few effective pharmacological treatment options exist for chronic back pain, the leading cause of disability in the US, and all are associated with significant adverse effects. OBJECTIVE: To determine the efficacy and safety of D-cycloserine,
Apkarian, A. Vania +5 more
core +2 more sources
Quality of life with ivabradine in patients with angina pectoris [PDF]
, 2016 Background—To explore the effect of ivabradine on angina-related quality of life (QoL) in patients participating in the Study Assessing the Morbidity–Mortality Benefits of the If Inhibitor Ivabradine in Patients with Coronary Artery Disease (SIGNIFY) QoL
Chassany, Olivier +6 more
core +1 more source
Racial Differences in the Effect of Granulocyte Macrophage Colony-Stimulating Factor on Improved Walking Distance in Peripheral Artery Disease: The PROPEL Randomized Clinical Trial. [PDF]
, 2019 Background The effects of race on response to medical therapy in people with peripheral artery disease ( PAD ) are unknown. Methods and Results In the PROPEL (Progenitor Cell Release Plus Exercise to Improve Functional Performance in PAD) Trial, PAD ...
Criqui, Michael H +11 more
core +1 more source
Effects of the anti-RANKL antibody denosumab on joint structural damage in patients with rheumatoid arthritis treated with conventional synthetic disease-modifying antirheumatic drugs (DESIRABLE study): a randomised, double-blind, placebo-controlled phase 3 trial. [PDF]
, 2019 ObjectiveTo evaluate the efficacy of denosumab in suppressing joint destruction when added to conventional synthetic disease-modifying antirheumatic drug (csDMARD) therapy in patients with rheumatoid arthritis (RA).MethodsThis was a multi-centre ...
Genant, Harry K +9 more
core +2 more sources
Non-Chemical Distant Cellular Interactions as a potential confounder of Cell Biology Experiments
Frontiers in Physiology, 2014 Distant cells can communicate with each other through a variety of methods. Two such methods involve electrical and/or chemical mechanisms. Non-chemical, distant cellular interactions may be another method of communication that cells can use to modify ...
Ashkan eFarhadi
doaj +1 more source
A double-blind study of the efficacy of apomorphine and its assessment in "off-periods in Parkinson's disease [PDF]
, 1993 Five patients with idiopathic Parkinson's disease with severe response fluctuations were selected for a randomized double-blind placebo-controlled study, concerning the clinical effects of subcutaneous apomorphine and its assessment in `off¿-periods. The
Essink, A.W.G. +4 more
core +3 more sources
Interaction between drug and placebo effects: a cross-over balanced placebo design trial [PDF]
, 2010 Background The total effect of a medication is the sum of its drug effect, placebo effect (meaning response), and their possible interaction. Current interpretation of clinical trials' results assumes no interaction. Demonstrating such an interaction has
Muhammad M Hammami +3 more
core +1 more source
A systematic review of sex differences in the placebo and the nocebo effect
Journal of Pain Research, 2017 Sara M Vambheim,1 Magne Arve Flaten2 1Department of Psychology, UiT, The Arctic University of Norway, Tromsø, 2Department of Psychology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway Objectives: The present review ...
Vambheim SM, Flaten MA
doaj
Clinical and Translational ScienceClinical trials often face challenges with placebo effects that can mask actual drug effects. We evaluated whether briefing the study team members on placebo mechanisms influenced analgesia.
Martin Coenen +8 more
doaj +1 more source