Results 21 to 30 of about 797,570 (234)

Effects of canagliflozin on cardiovascular biomarkers in older adults with type 2 diabetes [PDF]

, 2017
Background: Sodium glucose co-transporter 2 (SGLT2) inhibitors may reduce cardiovascular and heart failure risk in patients with type 2 diabetes mellitus (T2DM).
Butler, Javed, Davies, Michael J., Desai, Mehul, Januzzi, James L., Jarolim, Petr, Sattar, Naveed, Vijapurkar, Ujjwala   +6 more
core   +1 more source

Are Individual Learning Experiences More Important Than Heritable Tendencies? A Pilot Twin Study on Placebo Analgesia

Frontiers in Psychiatry, 2019
Objective: Predicting who will be a placebo responder is a prerequisite to maximize placebo effects in pain treatment and to minimize them in clinical trials. First evidence exists that genetics could affect placebo effects.
Katja Weimer, Katja Weimer, Elisabeth Hahn, Nils Mönnikes, Ann-Kathrin Herr, Andreas Stengel, Andreas Stengel, Paul Enck   +7 more
doaj   +1 more source

A Randomized, Controlled, Phase 2 Study of Maralixibat in the Treatment of Itching Associated With Primary Biliary Cholangitis. [PDF]

, 2019
Primary biliary cholangitis (PBC) is typically associated with elevated serum bile acid levels and pruritus, but pruritus is often refractory to treatment with existing therapies.
Apostol, George, Bacon, Bruce, Bowlus, Christopher L, Dorenbaum, Alejandro, Gu, Joan, Hirschfield, Gideon M, Jones, David, Kennedy, Ciara, Levy, Cynthia, Luketic, Velimir, Mayo, Marlyn J, Medendorp, Sharon, Novak, Patricia, Patanwala, Imran, Pockros, Paul J, Vuppalanchi, Raj   +15 more
core   +2 more sources

Patients’ experiences treated with open-label placebo versus double-blind placebo: a mixed methods qualitative study

BMC Psychology, 2022
Background There is increasing evidence suggesting that open-label placebo (OLP) is an effective treatment for several medical conditions defined by self-report.
Julia W. Haas, Giulio Ongaro, Eric Jacobson, Lisa A. Conboy, Judy Nee, Johanna Iturrino, Vikram Rangan, Anthony Lembo, Ted J. Kaptchuk, Sarah Ballou   +9 more
doaj   +1 more source

Improving adaptive response to negative stimuli through non-emotional working memory training

Frontiers in Behavioral Neuroscience, 2023
People with high working memory (WM) capacity tend to respond proactively and experience a decrease in undesired emotions, implying the potential influence of WM training on emotional responses.
Quanshan Long, Linlin Yu, Yancheng Tang, Qing Li, Na Hu, Yan Gu, Antao Chen   +6 more
doaj   +1 more source

Rolofylline, an adenosine A1−receptor antagonist, in acute heart failure [PDF]

, 2010
Background: Worsening renal function, which is associated with adverse outcomes, often develops in patients with acute heart failure. Experimental and clinical studies suggest that counterregulatory responses mediated by adenosine may be involved. We
Bloomfield, Daniel M, Cleland, John G F, Cotter, Gad, DeLucca, Paul, Dittrich, Howard C, Fu, Michael,, Givertz, Michael M, Mansoor, George A, Massie, Barry M, Metra, Marco, O'Connor, Christopher M, Ponikowski, Piotr, Salerno, Christina M, Teerlink, John R, Voors, Adriaan, Weatherley, Beth Davison   +15 more
core   +1 more source

Drug*placebo interaction effect may bias clinical trials interpretation: hybrid balanced placebo and randomized placebo-controlled design

BMC Medical Research Methodology, 2016
Background Conventional randomized placebo-controlled study design assumes the absence of drug*placebo interaction. We hypothesized the presence of such an interaction and that conventionally estimated drug effect might be biased.
Muhammad M. Hammami, Safa Hammami, Reem Al-Swayeh, Eman Al-Gaai, Faduma Abdi Farah, Sophia J. S. De Padua   +5 more
doaj   +1 more source

The effect of carbohydrate ingestion on the Interleukin-6 response to a 90-minute run time trial [PDF]

, 2009
Fatigue is a predictable outcome of prolonged physical activity; yet its biological cause remains uncertain. During exercise, a polypeptide messenger molecule interleukin- 6 (IL-6) is actively produced.
Ansley, Les, Barwood, Martin, Eglin, Clare, Robson-Ansley, Paula   +3 more
core   +1 more source

Alternative (non-hormonal) methods of menopausal disorder treatment. Assistance to the doctor-internist

Лечащий Врач, 2021
Climacteric syndrome (CS) is a pathological condition that occurs in a significant part of women in the menopause. Menopausal hormone therapy (MHT) is recognized as the most effective treatment for menopausal disorders. However, in real clinical practice,
I. V. Madyanov, T. S. Madyanova
doaj   +1 more source

Mixed Spices at Culinary Doses Have Prebiotic Effects in Healthy Adults: A Pilot Study. [PDF]

, 2019
Spices were used as food preservatives prior to the advent of refrigeration, suggesting the possibility of effects on microbiota. Previous studies have shown prebiotic activities in animals and in vitro, but there has not been a demonstration of ...
Carpenter, Catherine L, Gilbuena, Irene, Heber, David, Henning, Susanne M, Huang, Jianjun, Lee, Ru-Po, Li, Zhaoping, Lu, Qing-Yi, Rasmussen, Anna M, Shao, Paul, Thames, Gail, Yang, Jieping   +11 more
core   +1 more source