A Randomized, Controlled, Phase 2 Study of Maralixibat in the Treatment of Itching Associated With Primary Biliary Cholangitis. [PDF]
, 2019 Primary biliary cholangitis (PBC) is typically associated with elevated serum bile acid levels and pruritus, but pruritus is often refractory to treatment with existing therapies.
Apostol, George +15 more
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The Placebo Effect in Pain Therapies.
Annual Review of Pharmacology and Toxicology, 2019 Pharmacological strategies for pain management have primarily focused on dampening ascending neurotransmission and on opioid receptor-mediated therapies.
L. Colloca
semanticscholar +1 more source
DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot study [PDF]
, 2011 The impact of dietary n-3 PUFA on behavioural outcomes has been widely researched; however, very little attention has been given to their impact on brain functioning in physiological terms.
Jackson, Philippa +3 more
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Not a Placebo, but Is It Effective? [PDF]
Pain Medicine, 2013 Randomized, placebo-controlled studies are a rare commodity in interventional pain medicine. Pain Medicine , is therefore, pleased to publish such a study, in which Kappural et al. report their results of transdiscal biacuplasty for the treatment of chronic low back pain ⇓. Publication recognizes that a study was methodologically sound.
openaire +3 more sources
Journal of the American Medical Association (JAMA), 2021 Importance Standard first-line therapy for advanced or metastatic esophageal carcinoma is chemotherapy, but the prognosis remains poor. Camrelizumab (an anti-programmed death receptor 1 [PD-1] antibody) showed antitumor activity in previously treated ...
Hui‐yan Luo +29 more
semanticscholar +1 more source
The effect of carbohydrate ingestion on the Interleukin-6 response to a 90-minute run time trial [PDF]
, 2009 Fatigue is a predictable outcome of prolonged physical activity; yet its biological cause remains uncertain. During exercise, a polypeptide messenger molecule interleukin- 6 (IL-6) is actively produced.
Ansley, Les +3 more
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The Powerful Placebo Effect in Cough: Relevance to Treatment and Clinical Trials
Lung, 2019 Interest in the placebo effect of medicines has developed from the use of placebo treatments as controls in clinical trials into a whole new area of research around how placebos fit into a psychosocial model of therapeutics.
R. Eccles
semanticscholar +1 more source
Mixed Spices at Culinary Doses Have Prebiotic Effects in Healthy Adults: A Pilot Study. [PDF]
, 2019 Spices were used as food preservatives prior to the advent of refrigeration, suggesting the possibility of effects on microbiota. Previous studies have shown prebiotic activities in animals and in vitro, but there has not been a demonstration of ...
Carpenter, Catherine L +11 more
core +1 more source
International Journal of Research Publication and ReviewsThe graph to the right describes a study of 80 patients with irritable bowel syndrome (IBS). Patients either got no treatment or were given a placebo pill. When given the pill they were told “Placebo pills are made of an inert substance, like sugar pills,
Munnangi S +4 more
europepmc +3 more sources
Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 1, a pharmacokinetic/pharmacodynamic comparison with paroxetine in healthy men [PDF]
, 2015 We compared the effect of vortioxetine, paroxetine and placebo after three days of dosing on sleep architecture. This was a randomised, double-blind, four-way crossover, placebo-controlled, multiple-dose study in 24 healthy young men.
Areberg, J +4 more
core +1 more source