Placebo response and effect in randomized clinical trials: meta-research with focus on contextual effects [PDF]
Trials, 2021 Background Contextual effects (i.e., placebo response) refer to all health changes resulting from administering an apparently inactive treatment. In a randomized clinical trial (RCT), the overall treatment effect (i.e., the post-treatment effect in the ...
Sigurlaug H. Hafliðadóttir +6 more
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The Myth of the Placebo Response [PDF]
Frontiers in Psychiatry, 2019 The placebo response is a myth. It does not exist in reality, and continuing to name it is hindering the optimal application of science to healing in medicine.
Wayne B. Jonas
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Magnitude of placebo response in clinical trials of paroxetine for vasomotor symptoms: a meta-analysis [PDF]
Frontiers in Psychiatry, 2023 IntroductionVasomotor symptoms, or hot flashes, are among the most common complaints for menopausal and postmenopausal women. As an alternative to hormone replacement therapy, paroxetine mesylate became the only non-hormonal treatment approved by the U.S.
Joshua R. Rhodes +2 more
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JAMA Netw Open, 2022 Key Points Question What is the size of the placebo response in cannabinoid trials for clinical pain, and is the magnitude of placebo response associated with media attention on the trials?
Gedin F +8 more
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Development and Application of the Placebo Response Model in Clinical Trials for Primary Sjögren’s Syndrome [PDF]
Frontiers in Immunology, 2021 This study aimed to develop a placebo response model for pharmaceutical clinical trials of primary Sjogren’s syndrome,and to quantitatively analyze the distribution and related factors influencing the placebo response to further optimize the design of ...
ZHI-Zhou Wang +3 more
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Hype or hope? High placebo response in major depression treatment with ketamine and esketamine: a systematic review and meta-analysis [PDF]
Frontiers in PsychiatryBackgroundKetamine and esketamine offer a novel approach in the pharmacological treatment of major depressive disorder (MDD). This meta-analysis aimed to investigate the placebo response in double-blind, randomized controlled studies (RCTs) on patients ...
Alexandros Matsingos +7 more
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Pharmacogenomics and the Placebo Response [PDF]
ACS Chemical Neuroscience, 2018 There is perhaps no more important time in the history of placebos to consider their role in clinical trials and in medicine. Increasingly well-designed pharmaceutical and academic clinical trials testing promising and established drug and surgical interventions have failed to "beat" the placebo response.
Ted J. Kaptchuk +2 more
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Placebo response in trials with patients with anxiety, obsessive-compulsive and stress disorders across the lifespan: a three-level meta-analysis [PDF]
BMJ Mental Health, 2023 Question Randomised controlled trials assessing treatments for anxiety, obsessive-compulsive and stress-related disorders often present high placebo response rates in placebo groups.
Pim Cuijpers +10 more
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JAMA Netw Open, 2021 Key Points Question What is the placebo effect magnitude in different treatment modalities used for management of patients with treatment-resistant depression? Findings In this systematic review and meta-analysis of 3228 patients with treatment-resistant
Jones BDM +10 more
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Placebo Response in Rheumatoid Arthritis Clinical Trials. [PDF]
J Rheumatol, 2020 Objective. Understanding the placebo response is critical to interpreting treatment efficacy, particularly for agents with a ceiling to their therapeutic effect, where an increasing placebo response makes it harder to detect potential benefit.
Bechman K +4 more
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