The Myth of the Placebo Response [PDF]
Frontiers in Psychiatry, 2019 The placebo response is a myth. It does not exist in reality, and continuing to name it is hindering the optimal application of science to healing in medicine.
Wayne B. Jonas
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Magnitude of placebo response in clinical trials of paroxetine for vasomotor symptoms: a meta-analysis [PDF]
Frontiers in Psychiatry, 2023 IntroductionVasomotor symptoms, or hot flashes, are among the most common complaints for menopausal and postmenopausal women. As an alternative to hormone replacement therapy, paroxetine mesylate became the only non-hormonal treatment approved by the U.S.
Joshua R. Rhodes +2 more
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Development and Application of the Placebo Response Model in Clinical Trials for Primary Sjögren’s Syndrome [PDF]
Frontiers in Immunology, 2021 This study aimed to develop a placebo response model for pharmaceutical clinical trials of primary Sjogren’s syndrome,and to quantitatively analyze the distribution and related factors influencing the placebo response to further optimize the design of ...
ZHI-Zhou Wang +3 more
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Hype or hope? High placebo response in major depression treatment with ketamine and esketamine: a systematic review and meta-analysis [PDF]
Frontiers in PsychiatryBackgroundKetamine and esketamine offer a novel approach in the pharmacological treatment of major depressive disorder (MDD). This meta-analysis aimed to investigate the placebo response in double-blind, randomized controlled studies (RCTs) on patients ...
Alexandros Matsingos +7 more
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Placebo response in trials with patients with anxiety, obsessive-compulsive and stress disorders across the lifespan: a three-level meta-analysis [PDF]
BMJ Mental Health, 2023 Question Randomised controlled trials assessing treatments for anxiety, obsessive-compulsive and stress-related disorders often present high placebo response rates in placebo groups.
Pim Cuijpers +10 more
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The temporal trend of placebo response in migraine prevention from 1990 to 2021: a systematic literature review and meta-analysis with regression [PDF]
The Journal of Headache and Pain, 2023 Background Migraine affects 1.1 billion people globally and is the second leading cause of disability worldwide. In clinical trials, treatment efficacy is evaluated by comparing the differential responses in the treatment and placebo arms.
Stewart J. Tepper +10 more
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Placebo response and effect in randomized clinical trials: meta-research with focus on contextual effects [PDF]
Trials, 2021 Background Contextual effects (i.e., placebo response) refer to all health changes resulting from administering an apparently inactive treatment. In a randomized clinical trial (RCT), the overall treatment effect (i.e., the post-treatment effect in the ...
Sigurlaug H. Hafliðadóttir +6 more
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Re-evaluating the placebo response in recent canine dietary epilepsy trials [PDF]
BMC Veterinary ResearchThe placebo response is a common phenomenon. Limited evidence is available about its magnitude in canine epilepsy trials, even though it can significantly influence the efficacy evaluation of new treatments.
Teresa Schmidt +11 more
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Placebo response to intra-articular injections in knee osteoarthritis: magnitude, evolution over time, and influencing factors. A systematic review and meta-analysis with meta-regression [PDF]
EFORT Open ReviewsPurpose: To quantify the response to intra-articular saline administration in terms of pain, function, and quality of life, with a focus on the evolution of placebo response over time and the identification of influencing factors on the placebo response ...
Davide Previtali +4 more
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Report of similar placebo response in one internet versus onsite randomised controlled trials from the literature [PDF]
Osteoarthritis and Cartilage OpenObjective: The aim of this study was to compare the magnitude and the predictors of the placebo response in an internet versus onsite randomised controlled trials (RCTs) in people with hand osteoarthritis (HOA).
Arthur Ooghe +8 more
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