The Myth of the Placebo Response [PDF]
Frontiers in Psychiatry, 2019 The placebo response is a myth. It does not exist in reality, and continuing to name it is hindering the optimal application of science to healing in medicine.
Wayne B. Jonas
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Magnitude of placebo response in clinical trials of paroxetine for vasomotor symptoms: a meta-analysis [PDF]
Frontiers in Psychiatry, 2023 IntroductionVasomotor symptoms, or hot flashes, are among the most common complaints for menopausal and postmenopausal women. As an alternative to hormone replacement therapy, paroxetine mesylate became the only non-hormonal treatment approved by the U.S.
Joshua R. Rhodes +2 more
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Development and Application of the Placebo Response Model in Clinical Trials for Primary Sjögren’s Syndrome [PDF]
Frontiers in Immunology, 2021 This study aimed to develop a placebo response model for pharmaceutical clinical trials of primary Sjogren’s syndrome,and to quantitatively analyze the distribution and related factors influencing the placebo response to further optimize the design of ...
ZHI-Zhou Wang +3 more
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Hype or hope? High placebo response in major depression treatment with ketamine and esketamine: a systematic review and meta-analysis [PDF]
Frontiers in PsychiatryBackgroundKetamine and esketamine offer a novel approach in the pharmacological treatment of major depressive disorder (MDD). This meta-analysis aimed to investigate the placebo response in double-blind, randomized controlled studies (RCTs) on patients ...
Alexandros Matsingos +7 more
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Placebo response in trials with patients with anxiety, obsessive-compulsive and stress disorders across the lifespan: a three-level meta-analysis [PDF]
BMJ Mental Health, 2023 Question Randomised controlled trials assessing treatments for anxiety, obsessive-compulsive and stress-related disorders often present high placebo response rates in placebo groups.
Pim Cuijpers +10 more
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Placebo Responses in an Arthritis Trial [PDF]
Annals of the Rheumatic Diseases, 1961 Since the publication in this Journal of a description of the effects of placebos in rheumatoid conditions (Traut and Passerelli, 1957), there has been a growing literature on the subject of placebo responses, but little has appeared in print regarding such effects in arthritis.
Rutherford Morison +2 more
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The temporal trend of placebo response in migraine prevention from 1990 to 2021: a systematic literature review and meta-analysis with regression [PDF]
The Journal of Headache and Pain, 2023 Background Migraine affects 1.1 billion people globally and is the second leading cause of disability worldwide. In clinical trials, treatment efficacy is evaluated by comparing the differential responses in the treatment and placebo arms.
Stewart J. Tepper +10 more
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Placebo response in depression
Dialogues in Clinical Neuroscience, 2002 With its naturally fluctuating course, depression is a highly placebo-responsive condition: mean placebo response rates in antidepressant clinical trials are 30% to 40%. We review the history and terminology of placebo and the proposed mechanisms underlying the placebo response, including the physician-patient relationship and biological, sociocultural,
Shamsah B. Sonawalla +1 more
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Placebo response and effect in randomized clinical trials: meta-research with focus on contextual effects [PDF]
Trials, 2021 Background Contextual effects (i.e., placebo response) refer to all health changes resulting from administering an apparently inactive treatment. In a randomized clinical trial (RCT), the overall treatment effect (i.e., the post-treatment effect in the ...
Sigurlaug H. Hafliðadóttir +6 more
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Re-evaluating the placebo response in recent canine dietary epilepsy trials [PDF]
BMC Veterinary ResearchThe placebo response is a common phenomenon. Limited evidence is available about its magnitude in canine epilepsy trials, even though it can significantly influence the efficacy evaluation of new treatments.
Teresa Schmidt +11 more
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