Results 11 to 20 of about 8,509,826 (346)
The temporal trend of placebo response in migraine prevention from 1990 to 2021: a systematic literature review and meta-analysis with regression [PDF]
The Journal of Headache and Pain, 2023 Background Migraine affects 1.1 billion people globally and is the second leading cause of disability worldwide. In clinical trials, treatment efficacy is evaluated by comparing the differential responses in the treatment and placebo arms.
Stewart J. Tepper +10 more
doaj +2 more sources
Molecular Autism, 2020 Background Placebo response in autism spectrum disorder (ASD) might dilute drug-placebo differences and hinder drug development. Therefore, this meta-analysis investigated placebo response in core symptoms.
Spyridon Siafis +15 more
doaj +2 more sources
Placebo Responses in an Arthritis Trial [PDF]
Annals of the Rheumatic Diseases, 1961 Since the publication in this Journal of a description of the effects of placebos in rheumatoid conditions (Traut and Passerelli, 1957), there has been a growing literature on the subject of placebo responses, but little has appeared in print regarding such effects in arthritis.
Rutherford Morison +2 more
openalex +5 more sources
Brain Connectivity Predicts Placebo Response across Chronic Pain Clinical Trials. [PDF]
PLoS Biology, 2016 Placebo response in the clinical trial setting is poorly understood and alleged to be driven by statistical confounds, and its biological underpinnings are questioned.
Pascal Tétreault +5 more
doaj +2 more sources
Polygenic heterogeneity in antidepressant treatment and placebo response [PDF]
Translational Psychiatry, 2022 The genetic architecture of antidepressant response is poorly understood. Polygenic risk scores (PRS), exploration of placebo response and the use of sub-scales might provide insights.
Anne Krogh Nøhr +6 more
doaj +2 more sources
Re-evaluating the placebo response in recent canine dietary epilepsy trials [PDF]
BMC Veterinary ResearchThe placebo response is a common phenomenon. Limited evidence is available about its magnitude in canine epilepsy trials, even though it can significantly influence the efficacy evaluation of new treatments.
Teresa Schmidt +11 more
doaj +2 more sources
Placebo response in depression
Dialogues in Clinical Neuroscience, 2002 With its naturally fluctuating course, depression is a highly placebo-responsive condition: mean placebo response rates in antidepressant clinical trials are 30% to 40%. We review the history and terminology of placebo and the proposed mechanisms underlying the placebo response, including the physician-patient relationship and biological, sociocultural,
Shamsah B. Sonawalla +1 more
openalex +4 more sources
Neural Predictors of the Antidepressant Placebo Response [PDF]
Pharmaceuticals, 2019 The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates.
Danielle Rette +3 more
doaj +2 more sources
The therapeutic effect of clinical trials: understanding placebo response rates in clinical trials – A secondary analysis [PDF]
BMC Medical Research Methodology, 2005 Background and purpose Placebo response rates in clinical trials vary considerably and are observed frequently. For new drugs it can be difficult to prove effectiveness superior to placebo.
Walach Harald +3 more
doaj +2 more sources
Journal of the Peripheral Nervous System, 2014 The placebo response applies not only to phase II, but also to phase III studies and has clearly played a significant role in changing the way researchers need to approach conducting trials.
JT Farrar
openaire +4 more sources