Placebo response to intra-articular injections in knee osteoarthritis: magnitude, evolution over time, and influencing factors. A systematic review and meta-analysis with meta-regression [PDF]
EFORT Open ReviewsPurpose: To quantify the response to intra-articular saline administration in terms of pain, function, and quality of life, with a focus on the evolution of placebo response over time and the identification of influencing factors on the placebo response ...
Davide Previtali +4 more
doaj +2 more sources
Polygenic heterogeneity in antidepressant treatment and placebo response [PDF]
Translational Psychiatry, 2022 The genetic architecture of antidepressant response is poorly understood. Polygenic risk scores (PRS), exploration of placebo response and the use of sub-scales might provide insights.
Anne Krogh Nøhr +6 more
doaj +2 more sources
The therapeutic effect of clinical trials: understanding placebo response rates in clinical trials – A secondary analysis [PDF]
BMC Medical Research Methodology, 2005 Background and purpose Placebo response rates in clinical trials vary considerably and are observed frequently. For new drugs it can be difficult to prove effectiveness superior to placebo.
Walach Harald +3 more
doaj +2 more sources
Report of similar placebo response in one internet versus onsite randomised controlled trials from the literature [PDF]
Osteoarthritis and Cartilage OpenObjective: The aim of this study was to compare the magnitude and the predictors of the placebo response in an internet versus onsite randomised controlled trials (RCTs) in people with hand osteoarthritis (HOA).
Arthur Ooghe +8 more
doaj +2 more sources
Letter to Editor-response: placebo response rates [PDF]
EClinicalMedicine, 2023 Bishal Gyawali
doaj +2 more sources
Frontiers in Psychology, 2023 IntroductionPlacebo responsiveness is highly variable across individuals. In the domain of pain, it may range from pronounced hypoalgesia to no response at all.
Helena Hartmann +5 more
doaj +1 more source
European Headache Federation recommendations for placebo and nocebo terminology
The Journal of Headache and Pain, 2020 Background and aim Despite recent publications, practitioners remain unfamiliar with the current terminology related to the placebo and nocebo phenomena observed in clinical trials and practice, nor with the factors that modulate them.
Dimos D. Mitsikostas +17 more
doaj +1 more source
Placebo Effects on Stress, but Not on Pain Reports. A Multi-Experiment Study
Frontiers in Psychology, 2021 BackgroundContextual factors, such as participant/experimenter sex may moderate the placebo effects. We tested whether the participant and experimenter sex modulated placebo effects on experimentally induced pain and associated stress.ObjectiveTo ...
Sara Magelssen Vambheim +2 more
doaj +1 more source
Placebo response in trichotillomania [PDF]
International Clinical Psychopharmacology, 2017 Background: Trichotillomania is a functionally impairing, often overlooked disorder with no FDA-approved medications indicated for its treatment. The ability of clinical trials to detect beneficial effects of pharmacologic treatment in trichotillomania has been hampered by the high placebo response rate.
Samuel R. Chamberlain +9 more
openaire +4 more sources
Frontal alpha asymmetry: A potential biomarker of approach-withdrawal motivation towards pain
Frontiers in Pain Research, 2022 Pain-related catastrophising is a maladaptive coping strategy known to have a strong influence on clinical pain outcomes and treatment efficacy. Notwithstanding, little is known about its neurophysiological correlates.
Bárbara Silva-Passadouro +8 more
doaj +1 more source