Results 21 to 30 of about 317,198 (215)

On the Relationship Between Pain Variability and Relief in Randomized Clinical Trials

Frontiers in Pain Research, 2022
Previous research reports suggest greater baseline variability is associated with greater pain relief in those who receive a placebo. However, studies that evidence this association do not control for confounding effects from regression to the mean and ...
Siddharth R. Tiwari, Siddharth R. Tiwari, Andrew D. Vigotsky, Andrew D. Vigotsky, A. Vania Apkarian, A. Vania Apkarian   +5 more
doaj   +1 more source

Vertebroplasty and the Placebo Response [PDF]

Radiology, 2011
Our interpretation of the evidence for vertebroplasty has distinctive implications for clinical practice and health policy.
David F. Kallmes, Franklin G. Miller, Rachelle Buchbinder   +2 more
openaire   +3 more sources

Objective response rate of placebo in randomized controlled trials of anticancer medicinesResearch in context

EClinicalMedicine, 2023
Summary: Background: Spontaneous regression of advanced solid tumors is infrequent but may occur. Quantifying response rates from placebo in cancer drug trials may provide important information for physicians, patients, and regulators.
Arushi Sachdev, Isobel Sharpe, Meghan Bowman, Christopher M. Booth, Bishal Gyawali   +4 more
doaj   +1 more source

Neural Predictors of the Antidepressant Placebo Response

Pharmaceuticals, 2019
The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates.
Danielle Rette, Erin McDonald, Dan V. Iosifescu, Katherine A. Collins   +3 more
doaj   +1 more source

Pharmacogenomics and the Placebo Response [PDF]

ACS Chemical Neuroscience, 2018
There is perhaps no more important time in the history of placebos to consider their role in clinical trials and in medicine. Increasingly well-designed pharmaceutical and academic clinical trials testing promising and established drug and surgical interventions have failed to "beat" the placebo response.
Ted J. Kaptchuk, Joseph Loscalzo, Kathryn T. Hall   +2 more
openaire   +3 more sources

Influence on study outcomes of an inpatient study by the behavior of the study staff (PINgPOng): study protocol for a randomized clinical trial

Trials, 2022
Background The placebo effect as the symptom improvement following inert treatments is a fixed component of RCTs to differentiate between specific effects of the tested pharmacological substance from other unspecific effects.
Martin Coenen, Ulrike Bingel, Matthias Zunhammer, Maria Soledad Berdaguer, Christine Fuhrmann, Rolf Fimmers, Jens Rengelshausen, Gunther Hartmann, Manfred Schedlowski, Christoph Coch   +9 more
doaj   +1 more source

Placebo Effects in Psychotherapy: A Framework

Frontiers in Psychiatry, 2019
The issue of placebo response and the extent of its effect on psychotherapy is complex for two specific reasons: i) Current standards for drug trials, e.g., true placebo interventions, double-blinding, cannot be applied to most psychotherapy techniques ...
Paul Enck, Stephan Zipfel
doaj   +1 more source

Comparison of indirect treatment methods in migraine prevention to address differences in mode of administration

Journal of Comparative Effectiveness Research, 2023
Aim: Indirect treatment comparisons (ITCs) are anchored on a placebo comparator, and the placebo response may vary according to drug administration route.
Howard Thom, Stephane A Regnier, Xin Ying Lee, Steven Kymes, Lene Vase   +4 more
doaj   +1 more source

Placebo Economics: A Systematic Review About the Economic Potential of Utilizing the Placebo Effect

Frontiers in Psychiatry, 2019
Background: Recent research shows that placebo mechanisms can be utilized in ethical and legal ways such as in open-label conditions, when patients know that they receive placebos, and through psychological interventions aiming to optimize patients ...
Jens Hamberger, Jens Hamberger, Karin Meissner, Karin Meissner, Thilo Hinterberger, Thomas Loew, Katja Weimer   +6 more
doaj   +1 more source

Placebo response in migraine [PDF]

European Journal of Clinical Pharmacology, 2010
Sir I am currently in the process of revising the Guidelines for Drug Trials in Migraine of The International Headache Society. While browsing the literature for information on the placebo response in migraine randomised clinical trials (RCTs), I read with interest the extensive meta-analysis on this subject published by Macedo et al.
openaire   +3 more sources