Antidepressant drugs and the response in the placebo group: the real problem lies in our understanding of the issue [PDF]
, 2012 In a recent paper, Horder and colleagues (Horder et al., 2010, J Psychopharmacol 25: 1277–1288) have suggested that the mainproblem in the Kirsch analysis is methodological. We argue that the results are similar irrespective of the method used.
Bech P +8 more
core +1 more source
Efficacy and safety of secukinumab administration by autoinjector in patients with psoriatic arthritis: results from a randomized, placebo-controlled trial (FUTURE 3) [PDF]
, 2018 Background: The study aimed to assess 52-week efficacy and safety of secukinumab self-administration by autoinjector in patients with active psoriatic arthritis (PsA) in the FUTURE 3 study (ClinicalTrials.gov NCT01989468).
Andersson, Mats +11 more
core +1 more source
Neural Predictors of the Antidepressant Placebo Response
Pharmaceuticals, 2019 The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates.
Danielle Rette +3 more
doaj +1 more source
EClinicalMedicine, 2023 Summary: Background: Spontaneous regression of advanced solid tumors is infrequent but may occur. Quantifying response rates from placebo in cancer drug trials may provide important information for physicians, patients, and regulators.
Arushi Sachdev +4 more
doaj +1 more source
Thyroxine treatment in patients with symptoms of hypothyroidism but thyroid function tests within the reference range: randomised double blind placebo controlled crossover trial [PDF]
, 2001 OBJECTIVES: To determine whether thyroxine treatment is effective in patients with symptoms of hypothyroidism but with thyroid function tests within the reference range, and to investigate the effect of thyroxine treatment on psychological and physical ...
Davidson, K.M. +6 more
core +2 more sources
Placebo response in trichotillomania [PDF]
International Clinical Psychopharmacology, 2017 Background: Trichotillomania is a functionally impairing, often overlooked disorder with no FDA-approved medications indicated for its treatment. The ability of clinical trials to detect beneficial effects of pharmacologic treatment in trichotillomania has been hampered by the high placebo response rate.
Grant, Jon E. +7 more
openaire +4 more sources
The effect of carbohydrate ingestion on the Interleukin-6 response to a 90-minute run time trial [PDF]
, 2009 Fatigue is a predictable outcome of prolonged physical activity; yet its biological cause remains uncertain. During exercise, a polypeptide messenger molecule interleukin- 6 (IL-6) is actively produced.
Ansley, Les +3 more
core +1 more source
Trials, 2022 Background The placebo effect as the symptom improvement following inert treatments is a fixed component of RCTs to differentiate between specific effects of the tested pharmacological substance from other unspecific effects.
Martin Coenen +9 more
doaj +1 more source
Impact of onabotulinumtoxinA on quality of life and practical aspects of daily living : a pooled analysis of two randomized controlled trials [PDF]
, 2015 Objective: To evaluate the impact of onabotulinumtoxinA on individual domains of the quality of life questionnaires in a pooled analysis of two phase 3 trials in overactive bladder patients with urinary incontinence who were inadequately managed by >= 1 ...
Egerdie, Russell B +7 more
core +2 more sources
Placebo Economics: A Systematic Review About the Economic Potential of Utilizing the Placebo Effect
Frontiers in Psychiatry, 2019 Background: Recent research shows that placebo mechanisms can be utilized in ethical and legal ways such as in open-label conditions, when patients know that they receive placebos, and through psychological interventions aiming to optimize patients ...
Jens Hamberger +6 more
doaj +1 more source