Journal of Comparative Effectiveness Research, 2023 Aim: Indirect treatment comparisons (ITCs) are anchored on a placebo comparator, and the placebo response may vary according to drug administration route.
Howard Thom +4 more
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Placebo Effects in Psychotherapy: A Framework
Frontiers in Psychiatry, 2019 The issue of placebo response and the extent of its effect on psychotherapy is complex for two specific reasons: i) Current standards for drug trials, e.g., true placebo interventions, double-blinding, cannot be applied to most psychotherapy techniques ...
Paul Enck, Stephan Zipfel
doaj +1 more source
Telomere length as a predictor of response to Pioglitazone in patients with unremitted depression: a preliminary study. [PDF]
, 2016 We studied peripheral leukocyte telomere length (LTL) as a predictor of antidepressant response to PPAR-γ agonist in patients with unremitted depression.
Blackburn, E +4 more
core +1 more source
A double-blind study of the efficacy of apomorphine and its assessment in "off-periods in Parkinson's disease [PDF]
, 1993 Five patients with idiopathic Parkinson's disease with severe response fluctuations were selected for a randomized double-blind placebo-controlled study, concerning the clinical effects of subcutaneous apomorphine and its assessment in `off¿-periods. The
Essink, A.W.G. +4 more
core +3 more sources
Secukinumab versus adalimumab for psoriatic arthritis: comparative effectiveness up to 48 weeks using a matching-adjusted indirect comparison [PDF]
, 2018 Secukinumab and adalimumab are approved for adults with active psoriatic arthritis (PsA). In the absence of direct randomized controlled trial (RCT) data, matching-adjusted indirect comparison can estimate the comparative effectiveness in anti-tumor ...
Gandhi, Kunal +8 more
core +2 more sources
Twenty years after ‘Listening to Prozac but hearing placebo’. Do we hear placebo even louder?
Health Psychology Report, 2019 An active placebo is a substance that produces side effects similar to an active ingredient while not producing the same intended therapeutic effect. The aim of this study is to review the literature on the hypothesis of the active placebo response as a ...
Wojciech Oronowicz-Jaśkowiak +1 more
doaj +1 more source
A Phase II, Randomized, Double-Blind, Placebo-Controlled Study of Simtuzumab in Combination with FOLFIRI for the Second-Line Treatment of Metastatic KRAS Mutant Colorectal Adenocarcinoma. [PDF]
, 2017 Lessons learnedThe safety profile in the patient groups who received FOLFIRI and simtuzumab did not differ from that in the FOLFIRI and placebo group.The addition of simtuzumab to chemotherapy with FOLFIRI does not improve clinical outcomes in patients ...
Bendell, Johanna +5 more
core +1 more source
The effects of donepezil in Alzheimer's disease - Results from a multinational trial [PDF]
, 1999 Donepezil has been shown to be well tolerated and to improve cognition and global function in patients with mild to moderately severe Alzheimer's disease (AD).
Burns, A. +7 more
core +1 more source
Impact of sitagliptin on endometrial mesenchymal stem-like progenitor cells : a randomised, double-blind placebo-controlled feasibility trial [PDF]
, 2020 Background: Recurrent pregnancy loss (RPL) is associated with the loss of endometrial mesenchymal stem-like progenitor cells (eMSC). DPP4 inhibitors may increase homing and engraftment of bone marrow-derived cells to sites of tissue injury.
Brighton, Paul (Paul J.) +13 more
core +1 more source
Placebo response in migraine [PDF]
European Journal of Clinical Pharmacology, 2010 Sir I am currently in the process of revising the Guidelines for Drug Trials in Migraine of The International Headache Society. While browsing the literature for information on the placebo response in migraine randomised clinical trials (RCTs), I read with interest the extensive meta-analysis on this subject published by Macedo et al.
openaire +3 more sources