Results 1 to 10 of about 10,967 (189)

miR-203 secreted in extracellular vesicles mediates the communication between neural crest and placode cells required for trigeminal ganglia formation. [PDF]

PLoS Biology
While interactions between neural crest and placode cells are critical for the proper formation of the trigeminal ganglion, the mechanisms underlying this process remain largely uncharacterized.
Yanel E Bernardi, Estefania Sanchez-Vasquez, Rocío Belén Márquez, Michael L Piacentino, Hugo Urrutia, Izadora Rossi, Karina L Alcântara Saraiva, Antonio Pereira-Neves, Marcel I Ramirez, Marianne E Bronner, Natalia de Miguel, Pablo H Strobl-Mazzulla   +11 more
doaj   +3 more sources

Specification of Functional Cranial Placode Derivatives from Human Pluripotent Stem Cells

Cell Reports, 2013
Cranial placodes are embryonic structures essential for sensory and endocrine organ development. Human placode development has remained largely inaccessible despite the serious medical conditions caused by the dysfunction of placode-derived tissues. Here,
Zehra Dincer, Jinghua Piao, Lei Niu, Yosif Ganat, Sonja Kriks, Bastian Zimmer, Song-Hai Shi, Viviane Tabar, Lorenz Studer   +8 more
doaj   +4 more sources

FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells [PDF]

Nature Communications, 2018
Merkel cells are mechanoreceptors located in the epidermis whose developmental origin is unclear. Here the authors show that Merkel cells originate from SOX9 positive cells inside hair follicles and that FGFR2-mediated epithelial signalling is required ...
Minh Binh Nguyen, Idan Cohen, Vinod Kumar, Zijian Xu, Carmit Bar, Katherine L. Dauber-Decker, Pai-Chi Tsai, Pauline Marangoni, Ophir D. Klein, Ya-Chieh Hsu, Ting Chen, Marja L. Mikkola, Elena Ezhkova   +12 more
doaj   +7 more sources

Human Neural Cells Transiently Express Reelin during Olfactory Placode Development. [PDF]

PLoS ONE, 2015
Reelin, an extracellular glycoprotein is essential for migration and correct positioning of neurons during development. Since the olfactory system is known as a source of various migrating neuronal cells, we studied Reelin expression in the two ...
M Cristina Antal, Brigitte Samama, M Said Ghandour, Nelly Boehm   +3 more
doaj   +4 more sources

Local activation of Cxcl12a signaling controls olfactory placode morphogenesis in zebrafish embryos [PDF]

iScience
Summary: Morphogenesis and cell-type differentiation are highly coordinated in sensory organs to ensure their function. Morphogenesis of the olfactory placode in zebrafish provides a unique model to study this process as undifferentiated cells aligned ...
Marie Zilliox, Gaëlle Letort, David Sanchez, Christian Rouviere, Pascale Dufourcq, Frédérique Gaits-Iacovoni, Anne Pizzoccaro, Violaine Roussier-Michon, Patrick Blader, Julie Batut   +9 more
doaj   +2 more sources

Foxg1 Defines Ventrolateral Zonal Identity by Sustaining Neurogenic Progenitor Potential in the Olfactory Epithelium. [PDF]

Genes Cells
Foxg1 maintains neurogenic progenitor potential in the ventrolateral olfactory epithelium. In control (Foxg1‐cHET) embryos, Foxg1‐expressing progenitors preferentially generate olfactory sensory neurons (OSNs) and support V‐zone expansion. Conditional Foxg1 deletion (Foxg1‐cKO) reduces V‐zone growth and shifts progenitor fate toward sustentacular cells
Kuriyama A, Furusho Y, Hanashima C.
europepmc   +2 more sources

Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation [PDF]

eLife
Hair follicle development is initiated by reciprocal molecular interactions between the placode-forming epithelium and the underlying mesenchyme. Cell fate transformation in dermal fibroblasts generates a cell niche for placode induction by activation of
Mehmet Mahsum Kaplan, Erika Hudacova, Miroslav Matejcek, Haneen Tuaima, Jan Křivánek, Ondrej Machon   +5 more
doaj   +2 more sources

The Rho GTPase regulator ARHGEF3 orchestrates hair placode budding by coordinating cell fate and P-cadherin patterning in mice. [PDF]

PLoS Biology
During embryogenesis, cells self-organize into precise patterns that enable tissues and organs to acquire specialized functions. Despite its importance, the molecular choreography driving these collective cellular behaviors remains poorly understood ...
Krithika Kalyanakrishnan, Amy Beaudin, Alexandra Jetté, Sarah Ghezelbash, Diana Ioana Hotea, Jie Chen, Philippe Lefrançois, Mélanie Laurin   +7 more
doaj   +2 more sources

Bilateral Eyelid Agenesis With Multiple Congenital Ocular Anomalies in an Australian Labradoodle Puppy: Case Report and Surgical Management [PDF]

Vet Ophthalmol
ABSTRACT A 15‐week‐old Australian Labradoodle puppy was presented to The University of Queensland Small Animal Hospital for bilateral eyelid agenesis/coloboma and associated ocular complications. Enucleation of the left globe and repair of the right eyelid via a lip‐to‐lid transmucosal flap was performed. Given the subsequent development of prolapse of
Ng C, Ervedosa T, Soler J, Climans M, Gonzalez‐Astudillo V.   +4 more
europepmc   +2 more sources

The Development of Horns in Bovidae and the Genetic Mechanisms Underpinning This Process [PDF]

Biology
Horns in Bovidae, including bovines, sheep, and goats, are evolutionarily conserved cranial structures derived from cranial neural crest cells and composed of a bony core, dermis, epidermis, and keratinous sheath.
Xiaoli Xu, Wenwen Yan, Jiazhong Guo, Dinghui Dai, Li Li, Hongping Zhang   +5 more
doaj   +2 more sources