Results 11 to 20 of about 10,967 (189)

Cell interactions, signals and transcriptional hierarchy governing placode progenitor induction [PDF]

Development, 2017
In vertebrates, cranial placodes contribute to all sense organs and sensory ganglia and arise from a common pool of Six1/Eya2+ progenitors. Here we dissect the events that specify ectodermal cells as placode progenitors using newly identified genes upstream of the Six/Eya complex.
Mark Hintze, Ravindra Singh Prajapati, Monica Tambalo, Nicolas A. D. Christophorou, Maryam Anwar, Timothy Grocott, Andrea Streit   +6 more
openaire   +7 more sources

Insights Into the Early Gene Regulatory Network Controlling Neural Crest and Placode Fate Choices at the Neural Border

Frontiers in Physiology, 2020
The neural crest (NC) cells and cranial placodes are two ectoderm-derived innovations in vertebrates that led to the acquisition of a complex head structure required for a predatory lifestyle. They both originate from the neural border (NB), a portion of
Subham Seal, Subham Seal, Anne H. Monsoro-Burq, Anne H. Monsoro-Burq, Anne H. Monsoro-Burq   +4 more
doaj   +2 more sources

Close association of olfactory placode precursors and cranial neural crest cells does not predestine cell mixing [PDF]

Developmental Dynamics, 2012
AbstractVertebrate sensory organs originate from both cranial neural crest cells (CNCCs) and placodes. Previously, we have shown that the olfactory placode (OP) forms from a large field of cells extending caudally to the premigratory neural crest domain, and that OPs form through cell movements and not cell division. Concurrent with OP formation, CNCCs
Harden, Maegan V., Pereiro, Luisa, Ramialison, Mirana, Wittbrodt, Jochen, Prasad, Megana K., McCallion, Andrew S., Whitlock, Kathleen E.   +6 more
openaire   +9 more sources

Directional Cell Migration, but Not Proliferation, Drives Hair Placode Morphogenesis [PDF]

Developmental Cell, 2014
Epithelial reorganization involves coordinated changes in cell shapes and movements. This restructuring occurs during formation of placodes, ectodermal thickenings that initiate the morphogenesis of epithelial organs including hair, mammary gland, and tooth.
Renvoise Elodie, Thesleff Irma, Ahtiainen Laura, Vartiainen Maria K., Mikkola Marja L., Lindfors Päivi H., Lefebvre Sylvie, Shirokova Vera   +7 more
openaire   +3 more sources

Directed Differentiation of Human Embryonic Stem Cells Toward Placode-Derived Spiral Ganglion-Like Sensory Neurons

Stem Cells Translational Medicine, 2016
AbstractThe ability to generate spiral ganglion neurons (SGNs) from stem cells is a necessary prerequisite for development of cell-replacement therapies for sensorineural hearing loss. We present a protocol that directs human embryonic stem cells (hESCs) toward a purified population of otic neuronal progenitors (ONPs) and SGN-like cells.
Matsuoka, Akihiro J., Morrissey, Zachery D., Zhang, Chaoying, Homma, Kazuaki, Belmadani, Abdelhak, Miller, Charles A., Chadly, Duncan M., Kobayashi, Shun, Edelbrock, Alexandra N., Tanaka‐Matakatsu, Miho, Whitlon, Donna S., Lyass, Ljuba, McGuire, Tammy L., Stupp, Samuel I., Kessler, John A.   +14 more
openaire   +3 more sources

Lens placode planar cell polarity is dependent on Cdc42-mediated junctional contraction inhibition

Developmental Biology, 2016
Development of the ocular lens commences with the formation of the lens placode, an epithelial structure that thickens and subsequently bends inward in a process called invagination. Invagination is observed during the development of many embryonic structures, but the spectrum of morphogenetic events driving this process are, in most cases, not fully ...
Muccioli, Maria, Qaisi, Dalya, Herman, Ken, Plageman Jr., Timothy F.   +3 more
openaire   +3 more sources

Otic placode cell specification and proliferation are regulated by Notch signaling in avian development [PDF]

Developmental Dynamics, 2015
Background: The entire inner ear including the cochlear‐vestibular ganglion arises from a simple epithelium, the otic placode. Precursors for the placode originate from a pool of progenitors located in ectoderm next to the future hindbrain, the pre‐otic field, where they are intermingled with future epibranchial and epidermal cells.
Shida, Hiroko, Mende, Michael, Takano-Yamamoto, Teruko, Osumi, Noriko, Streit, Andrea, Wakamatsu, Yoshio   +5 more
openaire   +5 more sources

Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport [PDF]

Nature Communications, 2015
All cranial placode progenitors arise from a common precursor field anterior to the neural plate, the pre-placodal region (PPR). We showed that transcription factor Zic1, expressed at the anterior neural plate, is necessary and sufficient to promote placode fate.
Jaurena, Maria Belen, Juraver-Geslin, Hugo, Devotta, Arun, Saint-Jeannet, Jean-Pierre   +3 more
openaire   +3 more sources

Dynamic transcriptional signature and cell fate analysis reveals plasticity of individual neural plate border cells

eLife, 2017
The ‘neural plate border’ of vertebrate embryos contains precursors of neural crest and placode cells, both defining vertebrate characteristics. How these lineages segregate from neural and epidermal fates has been a matter of debate.
Daniela Roellig, Johanna Tan-Cabugao, Sevan Esaian, Marianne E Bronner   +3 more
doaj   +2 more sources

Differential expression pattern of Annexin A6 in chick neural crest and placode cells during cranial gangliogenesis. [PDF]

Gene Expr Patterns, 2015
Shah A, Taneyhill LA.
europepmc   +2 more sources