Results 51 to 60 of about 10,967 (189)

Neural Crest and Ectodermal Cells Intermix in the Nasal Placode to Give Rise to GnRH-1 Neurons, Sensory Neurons, and Olfactory Ensheathing Cells

Journal of Neuroscience, 2011
The origin of GnRH-1 cells and olfactory ensheathing cells has been controversial. Genetic Cre-lox lineage tracing of the neural crest (NC) versus ectodermal contribution to the developing nasal placode was performed using two complementary mouse models,
P. Forni, C. Taylor-Burds, V. Melvin, T. Williams, S. Wray   +4 more
semanticscholar   +1 more source

Delamination of cells from neurogenic placodes does not involve an epithelial-to-mesenchymal transition [PDF]

Development, 2007
Neurogenic placodes are specialized regions of embryonic ectoderm that generate the majority of the neurons of the cranial sensory ganglia. Here we examine in chick the mechanism underlying the delamination of cells from the epibranchial placodal ectoderm.
Graham, A, Blentic, A, Duque, S, Begbie, J   +3 more
openaire   +3 more sources

Critical roles of FGF, RA, and WNT signalling in the development of the human otic placode and subsequent lineages in a dish

Regenerative Therapy, 2022
Introduction: Efficient induction of the otic placode, the developmental origin of the inner ear from human pluripotent stem cells (hPSCs), provides a robust platform for otic development and sensorineural hearing loss modelling.
Tsubasa Saeki, Sho Yoshimatsu, Mitsuru Ishikawa, Chung-Chau Hon, Ikuko Koya, Shinsuke Shibata, Makoto Hosoya, Chika Saegusa, Kaoru Ogawa, Jay W. Shin, Masato Fujioka, Hideyuki Okano   +11 more
doaj   +1 more source

Lhx2 is required for patterning and expansion of a distinct progenitor cell population committed to eye development. [PDF]

PLoS ONE, 2011
Progenitor cells committed to eye development become specified in the prospective forebrain and develop subsequently into the optic vesicle and the optic cup. The optic vesicle induces formation of the lens placode in surface ectoderm from which the lens
Anna-Carin Hägglund, Lina Dahl, Leif Carlsson   +2 more
doaj   +1 more source

miR-29a-5p Inhibits Prenatal Hair Placode Formation Through Targeting EDAR by ceRNA Regulatory Network

Frontiers in Cell and Developmental Biology, 2022
Hair placode formation is an important stage of hair follicle morphogenesis and it is a complex process facilitated by non-coding RNAs. In this study, we conducted whole transcriptome sequencing analysis of skin, heart, liver, lung, and kidney tissues of
Yao Jiang, Yao Jiang, Huatao Liu, Quan Zou, Shujuan Li, Xiangdong Ding   +5 more
doaj   +1 more source

Differentiation of Sensory and Neuronal Cell Types from Neurogenic Placodes

, 2021
Chapter 6 discusses, how general mechanisms of sensory/neuronal differentiation are modulated in a placode-specific way to produce the specific sensory and neuronal cell types generated by individual placodes. For each placode, structure and function of its various derivative cell types is first reviewed, followed by an overview of transcription ...
openaire   +2 more sources

Directional cell movements downstream of Gbx2 and Otx2 control the assembly of sensory placodes [PDF]

Biology Open, 2016
ABSTRACTCranial placodes contribute to sensory structures including the inner ear, the lens and olfactory epithelium and the neurons of the cranial sensory ganglia. At neurula stages, placode precursors are interspersed in the ectoderm surrounding the anterior neural plate before segregating into distinct placodes by as yet unknown mechanisms. Here, we
Steventon, Ben, Mayor, Roberto, Streit, Andrea   +2 more
openaire   +6 more sources

Extensive Cell Movements Accompany Formation of the Otic Placode

Developmental Biology, 2002
During development, the vertebrate inner ear arises from the otic placode, a thickened portion of the ectoderm next to the hindbrain. Here, the first detailed fate maps of this region in the chick embryo are presented. At head process stages, placode precursors are scattered throughout a large region of the embryonic ectoderm, where they intermingle ...
openaire   +3 more sources

Genotypes and Phenotypes of Patients With TSPEAR‐Related Disorder: Evidence of a Predominant Dental Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT TSPEAR (chr. 21q22.3) encodes a protein involved in tooth development and is predominantly expressed in the enamel knot. Biallelic loss of function variants in TSPEAR cause ectodermal dysplasia, tooth agenesis and sensorineural hearing loss. However, the role of TSPEAR in auditory processes is unclear.
Debora Vergani, Lucia Tiberi, Annarita Giliberti, Elia Dirupo, Laila Zaroili, Francesco Brancati, Michela Brena, Stefano Caraffi, Chiara De Luca, Livia Garavelli, Anna Virginia Gulino, Milena Mariani, Marzia Pollazzon, Angelo Selicorni, Samuela Landini, Ilaria Sani, Rosangela Artuso, Angela Peron   +17 more
wiley   +1 more source

Retinoic acid and FGF10 promote the differentiation of pluripotent stem cells into salivary gland placodes

Stem Cell Research & Therapy, 2022
Abstract Background Salivary glands produce saliva that play essential roles in digestion and oral health. Derivation of salivary gland organoids from pluripotent stem cells (PSCs) provides a powerful platform to model the organogenesis processes during development.
Siqi Zhang, Yi Sui, Shuang Yan, Yifei Zhang, Chong Ding, Xiaodong Su, Jingwei Xiong, Shicheng Wei   +7 more
openaire   +3 more sources