Results 51 to 60 of about 30,986 (262)

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Phosphorus-induced change in root hair growth is associated with IAA accumulation in walnut

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2021
Walnut, an important non-wood product forest tree, has free root hairs in orchards. Root hairs are specialized cells originating from the root epidermis that are regulated by plant hormones, such as auxins. This study was conducted to evaluate the effect
Yongjie XU, Chunyong XU, Dejian ZHANG, Xianzhen DENG   +3 more
doaj   +1 more source

Let there be light: Regulation of gene expression in plants [PDF]

RNA Biology, 2014
Gene expression regulation relies on a variety of molecular mechanisms affecting different steps of a messenger RNA (mRNA) life: transcription, processing, splicing, alternative splicing, transport, translation, storage and decay. Light induces massive reprogramming of gene expression in plants.
Ezequiel Petrillo, Micaela A Godoy Herz, Andrea Barta, Maria Kalyna, Alberto R Kornblihtt   +4 more
openaire   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Dynamic plastid redox signals integrate gene expression and metabolism to induce distinct metabolic states in photosynthetic acclimation in Arabidopsis [PDF]

, 2009
Plants possess acclimation responses in which structural reconfigurations adapt the photosynthetic apparatus to fluctuating illumination. Long-term acclimation involves changes in plastid and nuclear gene expression and is controlled by redox signals ...
Dietz, K., Leister, D., Radke, Dörte, Bräutigam, Katharina, Wirtz, Markus, Radke, D., Fernie, A. R., Peter Dörmann, Wormuth, Dennis, Hell, Ruediger, Fernie, Alisdair R., Stroher, E., Hell, Rüdiger, Lars Dietzel, Hell, R., Wormuth, D., Oliver, S. N., Dietzel, L., Pfannschmidt, T., Fernie, A., Leister, Dario, Tatjana Kleine, Thomas Pfannschmidt, Dörmann, Peter, Nunes-Nesi, Adriano, Kleine, T., Pfannschmidt, Thomas, Dietz, K. J., Radke, Doerte, Dietz, Karl-Josef, Elke Ströher, Rüdiger Hell, Ströher, Elke, Nicolas Schauer, Katharina Bräutigam, Stroeher, Elke, Karl-Josef Dietz, Peter Geigenberger, Alisdair R. Fernie, Kleine, Tatjana, Dörte Radke, Dennis Wormuth, Wirtz, M., Oliver, Sandra N., Braeutigam, Katharina, Markus Wirtz, Brautigam, K., Dietzel, Lars, Schauer, Nicolas, Doermann, Peter, Sandra N. Oliver, Dario Leister, Oliver, S., Nunes-Nesi, A., Schauer, N., Geigenberger, P., Geigenberger, Peter, Adriano Nunes-Nesi, Doermann, P.   +58 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Plant Promoters: Their Identification, Characterization, and Role in Gene Regulation

, 2023
One of the strategies to overcome diseases or abiotic stress in crops is the use of improved varieties. Genetic improvement could be accomplished through different methods, including conventional breeding, induced mutation, genetic transformation, or ...
Ricardo Pacheco-Coello, Tatiana Chávez-Navarrete, Eduardo Sánchez-Timm, Efrén Santos-Ordóñez, Liliana Villao-Uzho   +4 more
core   +1 more source

The Diversity of Plant Small RNAs Silencing Mechanisms

CHIMIA, 2019
Small RNAs gene regulation was first discovered about 20 years ago. It represents a conserve gene regulation mechanism across eukaryotes and is associated to key regulatory processes.
Jens A. Schröder, Pauline E. Jullien
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source