Results 51 to 60 of about 7,959,234 (301)

Wigwams : identifying gene modules co-regulated across multiple biological conditions [PDF]

, 2014
Motivation: Identification of modules of co-regulated genes is a crucial first step towards dissecting the regulatory circuitry underlying biological processes. Co-regulated genes are likely to reveal themselves by showing tight co-expression, e.g.
Rhodes, Johanna, Jenkins, Dafyd J, Jironkin, Aleksey, Kiddle, Steven J., Beynon, Jim, Buchanan-Wollaston, Vicky, Kiddle, Steven J, Hills, Claire E., Denby, Katherine J, Denby, Katherine J., Hill, Claire, Jenkins, Dafyd J., Zhang, Peijun, Polański, Krzysztof, Kiddle, Steven, Ott, Sascha, Rhodes, Johanna; id_orcid   +16 more
core   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Recent trends in miRNA therapeutics and the application of plant miRNA for prevention and treatment of human diseases

Future Journal of Pharmaceutical Sciences, 2022
Background Researchers now have a new avenue to investigate when it comes to miRNA-based therapeutics. miRNAs have the potential to be valuable biomarkers for disease detection.
Atiyabanu N. Saiyed, Abhay R. Vasavada, S. R. Kaid Johar   +2 more
doaj   +1 more source

Building Transcription Factor Binding Site Models to Understand Gene Regulation in Plants.

Molecular Plant, 2019
Transcription factors (TFs) are key cellular components that control gene expression. They recognize specific DNA sequences, the TF binding sites (TFBSs), and thus are targeted to specific regions of the genome where they can recruit transcriptional co ...
X. Lai, Arnaud Stigliani, G. Vachon, Cristel C. Carles, C. Smaczniak, C. Zubieta, K. Kaufmann, F. Parcy   +7 more
semanticscholar   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Down-regulation of CBP80 gene expression as a strategy to engineer a drought-tolerant potato [PDF]

, 2012
Developing new strategies for crop plants to respond to drought is crucial for their innovative breeding. The down-regulation of nuclear cap-binding proteins in Arabidopsis renders plants drought tolerant.
Strzelczyk-Zyta, Danuta, Szweykowska-Kulinska, Zofia, Bielewicz, Dawid, Dolata, Jakub, Piontek, Paulina, Wyrzykowska, Anna, Krusiewicz, Dominika, Jarmołowski, Artur, Krzeslowska, Magdalena, Hennig, Jacek, Pieczynski, Marcin, Konopka-Postupolska, Dorota, Marczewski, Waldemar   +12 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Phosphorus-induced change in root hair growth is associated with IAA accumulation in walnut

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2021
Walnut, an important non-wood product forest tree, has free root hairs in orchards. Root hairs are specialized cells originating from the root epidermis that are regulated by plant hormones, such as auxins. This study was conducted to evaluate the effect
Yongjie XU, Chunyong XU, Dejian ZHANG, Xianzhen DENG   +3 more
doaj   +1 more source

The genome awakens: transposon-mediated gene regulation.

Trends in Plant Science
Current progress in plant genomics has uncovered important roles of transposable elements (TEs) in gene regulation and has transformed their perception from 'junk DNA' to key genomic players.
Ileana Tossolini, Regina Mencia, A. Arce, P. Manavella   +3 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source