Results 71 to 80 of about 2,579,616 (291)

Acknowledgement to Reviewers of Toxins in 2014

, 2015
The editors of Toxins would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2014:[...
Toxins Editorial Office
core   +1 more source

Extracts Prepared from a Canadian Toxic Plant Induce Light-Dependent Perinuclear Vacuoles in Human Cells

, 2021
We are investigating plant species from the Canadian prairie ecological zone by phenotypic cell assays to discover toxins of biological interest. We provide the first report of the effects of extracts prepared from the shrub Symphoricarpos occidentalis ...
Andersen, Raymond J., Benjamin Yeremy, Tuescher, Jan M., Raymond J. Andersen, Chad R. Beck, Roy M. Golsteyn, Spencer, Locke, Yeremy, Benjamin, Jan M. Tuescher, Golsteyn, Roy M., Shi, Yutong, Locke Spencer, Beck, Chad R., Yutong Shi   +13 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Analysis of 113 Mycotoxins and Plant Toxins in Wheat, Soy and Pea Protein Concentrates from the German Market Reveals, i.a., a High Prevalence of Alterperylenol in Wheat Gluten

Toxins
Wheat, soy and pea protein isolates used for the production of plant-based meat alternatives were analyzed for 87 mycotoxins and 26 plant toxins by means of a validated QuEChERS-based LC-MS/MS multi-method.
Ahmed H. El-Khatib, Arnold Bahlmann, Christoph Hutzler, Stefan Weigel   +3 more
doaj   +1 more source

Plant Toxin-Based Immunotoxins for Cancer Therapy: A Short Overview

Biomedicines, 2016
Immunotoxins are chimeric proteins obtained by linking a toxin to either an intact antibody or an antibody fragment. Conjugation can be obtained by chemical or genetic engineering, where the latter yields recombinant conjugates.
Letizia Polito, Alice Djemil, Massimo Bortolotti   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Retrograde transport pathways utilised by viruses and protein toxins [PDF]

, 2006
A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
J Michael Lord, Lord, Mike, Spooner, Robert A., Smith, Daniel C., Daniel C Smith, Roberts, L. M. (Lynne M.), Andrew J Easton, Easton, A. J. (Andrew J.), Robert A Spooner, Lynne M Roberts   +9 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Membrane‐Damaging Toxins: Family of RTX Toxins

, 2003
The major cellular effect of RTX toxins has been ascribed to their pore‐forming capacity, resulting in plasma membrane lesions and osmotic lysis.
Oxhamre, C, Richter‐Dahlfors, A
core   +1 more source