Results 31 to 40 of about 165,729 (227)
Frontiers in Cell and Developmental Biology, 2022 After damage, cells repair their plasma membrane in an active process that is driven by Ca2+ entering through the wound. This triggers a range of Ca2+-regulated events such as the translocation of different Ca2+-binding proteins to the wound site which ...
Arsila P. K. Ashraf, Volker Gerke
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Requirement for Annexin A1 in Plasma Membrane Repair [PDF]
Journal of Biological Chemistry, 2006 Ca2+ entering a cell through a torn or disrupted plasma membrane rapidly triggers a combination of homotypic and exocytotic membrane fusion events. These events serve to erect a reparative membrane patch and then anneal it to the defect site. Annexin A1 is a cytosolic protein that, when activated by micromolar Ca2+, binds to membrane phospholipids ...
Anna K, McNeil +3 more
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High-Throughput Microplate-Based Assay to Monitor Plasma Membrane Wounding and Repair
Frontiers in Cellular and Infection Microbiology, 2017 The plasma membrane of mammalian cells is susceptible to disruption by mechanical and biochemical damages that frequently occur within tissues. Therefore, efficient and rapid repair of the plasma membrane is essential for maintaining cellular homeostasis
Sarika Pathak-Sharma +6 more
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Early Endosomes Act as Local Exocytosis Hubs to Repair Endothelial Membrane Damage
Advanced Science, 2023 The plasma membrane of a cell is subject to stresses causing ruptures that must be repaired immediately to preserve membrane integrity and ensure cell survival.
Nikita Raj +9 more
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Pathogenesis of Multiple Organ Failure: The Impact of Systemic Damage to Plasma Membranes
Frontiers in Medicine, 2022 Multiple organ failure (MOF) is the major cause of morbidity and mortality in intensive care patients, but the mechanisms causing this severe syndrome are still poorly understood.
Andrey V. Kozlov +5 more
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Plasma membrane wounding and repair in pulmonary diseases [PDF]
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2017 Various pathophysiological conditions such as surfactant dysfunction, mechanical ventilation, inflammation, pathogen products, environmental exposures, and gastric acid aspiration stress lung cells, and the compromise of plasma membranes occurs as a result.
Xiaofei, Cong +3 more
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Promotion of plasma membrane repair by vitamin E [PDF]
Nature Communications, 2011 Severe vitamin E deficiency results in lethal myopathy in animal models. Membrane repair is an important myocyte response to plasma membrane disruption injury as when repair fails, myocytes die and muscular dystrophy ensues. Here we show that supplementation of cultured cells with α-tocopherol, the most common form of vitamin E, promotes plasma ...
Howard, Amber Cyran +2 more
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Repurposing phenothiazines for cancer therapy: compromising membrane integrity in cancer cells
Frontiers in Oncology, 2023 The limitations of current cancer therapies, including the increasing prevalence of multidrug resistance, underscore the urgency for more effective treatments. One promising avenue lies in the repurposing of existing drugs.
Syrina Fred Mehrabi +3 more
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Effect of Antarctic Krill Oil Supplementation on Skeletal Muscle Plasma Membrane Repair in Mice after Exhaustive Exercise [PDF]
Shipin Kexue, 2023 Objective: To investigate the effects of supplementation of Antarctic krill oil (KO) on muscle plasma membrane injury and functional recovery in mice after exhaustive exercise, and to explore the possible mechanism by which KO supplementation promotes ...
YANG Simeng, HE Qing, SHI Lijun, WU Ying
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Frontiers in Microbiology, 2021 Staphylococcus aureus (S. aureus) is well known to express a plethora of toxins of which the pore-forming hemolysin A (α-toxin) is the best-studied cytolysin.
David Krones +8 more
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