Results 31 to 40 of about 312,836 (267)

Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair [PDF]

, 2011
Eukaryotic cells possess a universal repair machinery that ensures rapid resealing of plasma membrane disruptions. Before resealing, the torn membrane is submitted to considerable tension, which functions to expand the disruption.
A Brisson, A Brisson, AK McNeil, B Brachvogel, B Brachvogel, B Brachvogel, B Jeppesen, C Cai, C Cai, C Pigault, C Vénien-Bryan, CE Creutz, CJ Merrifield, D Bansal, D Bansal, D Voges, EB Babiychuk, F D'Acquisto, F Oling, F Oling, G Mosser, GQ Bi, HA Andree, I Reviakine, J Liu, JH Rand, K Balasubramanian, K Monastyrskaya, L Glover, M Menke, M Rodahl, MA Kaetzel, MA Swairjo, MP Sheetz, NJ Lennon, NO Concha, NO Concha, O Lambert, O Saurel, PL McNeil, PL McNeil, PL McNeil, Q Ling, R Bérat, R Huber, R Huber, R Langen, R Richter, RA Steinhardt, RP Richter, S Yasuda, SE Moss, T Skrahina, T Togo, T Yeung, V Gerke, Y Mo   +56 more
core   +2 more sources

Plasma membrane recovery kinetics of a microfluidic intracellular delivery platform [PDF]

, 2013
Intracellular delivery of materials is a challenge in research and therapeutic applications. Physical methods of plasma membrane disruption have recently emerged as an approach to facilitate the delivery of a variety of macromolecules to a range of cell ...
Cho, Nahyun, Eyerman, Alexandra T., Hartoularos, George C., Jackson, Emily L., Jang, Derek Y., Jensen, Klavs F, Jhunjhunwala, Siddharth, Langer, Robert S, Mao, Shirley, Poceviciute, Roberta, Schoettle, Taylor, Sharei, Armon Reza   +11 more
core   +1 more source

High-Throughput Microplate-Based Assay to Monitor Plasma Membrane Wounding and Repair

Frontiers in Cellular and Infection Microbiology, 2017
The plasma membrane of mammalian cells is susceptible to disruption by mechanical and biochemical damages that frequently occur within tissues. Therefore, efficient and rapid repair of the plasma membrane is essential for maintaining cellular homeostasis
Sarika Pathak-Sharma, Xiaoli Zhang, Jonathan G. T. Lam, Jonathan G. T. Lam, Noah Weisleder, Stephanie M. Seveau, Stephanie M. Seveau   +6 more
doaj   +1 more source

Early Endosomes Act as Local Exocytosis Hubs to Repair Endothelial Membrane Damage

Advanced Science, 2023
The plasma membrane of a cell is subject to stresses causing ruptures that must be repaired immediately to preserve membrane integrity and ensure cell survival.
Nikita Raj, Lilo Greune, Martin Kahms, Karina Mildner, Rico Franzkoch, Olympia Ekaterini Psathaki, Thomas Zobel, Dagmar Zeuschner, Jürgen Klingauf, Volker Gerke   +9 more
doaj   +1 more source

Pathogenesis of Multiple Organ Failure: The Impact of Systemic Damage to Plasma Membranes

Frontiers in Medicine, 2022
Multiple organ failure (MOF) is the major cause of morbidity and mortality in intensive care patients, but the mechanisms causing this severe syndrome are still poorly understood.
Andrey V. Kozlov, Andrey V. Kozlov, Andrey V. Kozlov, Johannes Grillari, Johannes Grillari, Johannes Grillari   +5 more
doaj   +1 more source

Calpains, Cleaved Mini-Dysferlin(C72), and L-Type Channels Underpin Calcium-Dependent Muscle Membrane Repair [PDF]

, 2013
Dysferlin is proposed as a key mediator of calcium-dependent muscle membrane repair, although its precise role has remained elusive. Dysferlin interacts with a new membrane repair protein, mitsugumin 53 (MG53), an E3 ubiquitin ligase that shows rapid ...
Cooper, ST, Evesson, FJ, Lek, A, Lemckert, FA, Lueders, AK, North, KN, Redpath, GMI, Turnbull, L, Whitchurch, CB   +8 more
core   +3 more sources

Vapor nanobubble is the more reliable photothermal mechanism for inducing endosomal escape of siRNA without disturbing cell homeostasis [PDF]

, 2020
Strategies for controlled delivery of therapeutic siRNA into living cells are in high demand as endosomal escape remains the most prominent bottleneck at the intracellular level.
Barriga, Gerardo Garcia-Diaz, Braeckmans, Kevin, Brans, Toon, De Keulenaer, Sarah, De Rycke, Riet, De Smedt, Stefaan, De Vos, Winnok H., Fraire, Juan, Houthaeve, Gaëlle, Liu, Jing, Mestdagh, Pieter, Raemdonck, Koen, Raes, Laurens, Stremersch, Stephan, Van Nieuwerburgh, Filip, Vandesompele, Jo, Vermeulen, Lotte   +16 more
core   +2 more sources

Microvesicles as vehicles for tissue regeneration: Changing of the guards [PDF]

, 2016
Purpose of Review: Microvesicles (MVs) have been recognised as mediators of stem cell function, enabling and guiding their regenerative effects. Recent Findings: MVs constitute one unique size class of extracellular vesicles (EVs) directly shed from ...
Davies, R. Wayne, Panagiotou, Nikolaos, Selman, Colin, Shiels, Paul G.   +3 more
core   +1 more source

Repurposing phenothiazines for cancer therapy: compromising membrane integrity in cancer cells

Frontiers in Oncology, 2023
The limitations of current cancer therapies, including the increasing prevalence of multidrug resistance, underscore the urgency for more effective treatments. One promising avenue lies in the repurposing of existing drugs.
Syrina Fred Mehrabi, Sabina Elmi, Jesper Nylandsted, Jesper Nylandsted   +3 more
doaj   +1 more source

Effect of Antarctic Krill Oil Supplementation on Skeletal Muscle Plasma Membrane Repair in Mice after Exhaustive Exercise [PDF]

Shipin Kexue, 2023
Objective: To investigate the effects of supplementation of Antarctic krill oil (KO) on muscle plasma membrane injury and functional recovery in mice after exhaustive exercise, and to explore the possible mechanism by which KO supplementation promotes ...
YANG Simeng, HE Qing, SHI Lijun, WU Ying
doaj   +1 more source