Results 81 to 90 of about 59,254 (297)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Current concepts in platelet transfusion
Asian Journal of Transfusion Science, 2009 This is the era of component therapy. Therefore there is a need for rational use of platelet concentrate. Lot of knowledge has been added recently in the field of platelet specially about the platelet rich plasma and its application in clinical practice.
Mohanty Dipika
doaj
Providing the Gift of Life: Canadian Medical Practitioners and the Treatment of Shock on the Battlefield [PDF]
, 2012 The story of Ambroise Pare’s discovery has been told often; of how, during Francis I’s campaign against Turin in 1536-37, he ran out of the oil medical practitioners used to cauterize the stumps of amputees and used an herbal remedy and ligatures instead;
Rawling, Bill
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
FoodsThe clean-label movement has markedly increased consumer demand for meat products free from synthetic additives, such as sodium nitrite, ascorbate, and phosphate.
Minhyeong Kim +4 more
doaj +1 more source
Cavitating Langmuir Turbulence in the Terrestrial Aurora [PDF]
, 2012 Langmuir cavitons have been artificially produced in the earth's ionosphere, but evidence of naturally-occurring cavitation has been elusive. By measuring and modeling the spectra of electrostatic plasma modes, we show that natural cavitating, or strong,
B. Isham +6 more
core +4 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Will There Be Blood? Incentives and Substitution Effects in Pro-social Behavior [PDF]
We examine how economic incentives affect pro-social behavior through the analysis of a unique dataset with information on more than 14,000 American Red Cross blood drives.
Lacetera, Nicola +2 more
core
HPTLC assay of nicotine and cotinine in biological samples [PDF]
, 2018 This study presents the development of a simple high-performance thin layer chromatography (HPTLC) method for the determination of nicotine and its metabolite cotinine in human plasma and urine.
Baconi, Daniela Luiza +6 more
core +1 more source
Lactation and neonatal nutrition: defining and refining the critical questions. [PDF]
, 2012 This paper resulted from a conference entitled "Lactation and Milk: Defining and refining the critical questions" held at the University of Colorado School of Medicine from January 18-20, 2012.
Ardythe L. Morrow +37 more
core +2 more sources