Results 171 to 180 of about 45,338 (267)

Single‐cell and repertoire profiling reveals immune remodelling in paediatric upper airway: insights from adenoid hypertrophy

Clinical &Translational Immunology, Volume 15, Issue 6, 2026.
Single‐cell and paired V(D)J profiling show that paediatric adenoid hypertrophy features expanded proliferative germinal‐centre B cells with impaired maturation. Abstract Objectives To characterise the immune cellular landscape and paired B‐cell and T‐cell receptor repertoires of hypertrophic adenoids in children with obstructive sleep apnoea.
Chao Wang, Yufei Pan, Xiao Han, Kai Sun, Jing Li, Yuanyuan Lu, Zhenkun Yu   +6 more
wiley   +1 more source

Plasmacytoid dendritic cells modulate the production of mucosal IgA in IgA nephropathy. [PDF]

Nephrol Dial Transplant
Fukao Y, Suzuki H, Nihei Y, Makita Y, Kano T, Nakayama M, Lee M, Kato R, Kihara M, Suzuki Y.   +9 more
europepmc   +1 more source

Control of poorly immunogenic tumors with systemic STING agonist‐loaded liposomes targeting cross‐presenting dendritic cells

Clinical &Translational Immunology, Volume 15, Issue 6, 2026.
WH‐peptide‐functionalised liposomes encapsulating STING or RIG‐I agonists target intra‐tumoral Clec9A+ cDC1 and pDC, triggering release of type 1 IFN, presentation of CD4 and CD8 endogenous tumor epitopes, expansion of CTL with help from CD4 T cells in spleen, and tumor cell killing.
Bijun Zeng, Meghna Talekar, Thais Aragao‐Horoiwa, Amy Cameron, Guangzu Zhao, Yulia Zybina, Wendy Blumenschein, Karyn van de Mark, Wittaya Suwakulsiri, Gretchen A Baltus, Riccardo Dolcetti, Ranjeny Thomas   +11 more
wiley   +1 more source

Persistent Increased Plasmacytoid Dendritic Cells and Inflammation in People With HIV Years After Tuberculosis. [PDF]

J Infect Dis
Ward M, Zumbo P, Joseph Y, Apollon A, Alonso A, Betel D, Fitzgerald DW, Pape JW, Dupnik KM.   +8 more
europepmc   +1 more source

Single‐cell profiling reveals peripheral blood immune landscape remodelling in breast cancer lymph node metastasis

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
scRNA‐seq reveals pro‐metastatic neutrophil and exhausted T/NK subsets in BC patients with LN metastasis. Interferon‐stimulated neutrophils secrete LGALS9, drives T/NK cell exhaustion via HAVCR2. Neutralising LGALS9 restores T‐cell anti‐tumour activity, suggesting a novel therapeutic target.
Bo Chen, Kang Ma, Yunjie Wang, Liulu Zhang, Xinyue Feng, Cheng Long, Xuejing Tan, Kun Wang   +7 more
wiley   +1 more source

Age- and tissue-dependent diversity of human plasmacytoid dendritic cells uncovers a cycling subset dominant in early life and cancer. [PDF]

Immunity
Antonova AU, Rodrigues PF, Mannie C, Ferrari G, Carvajal H, Bugatti M, Vermi W, Wu T, Cella M, Eghtesady P, Colonna M.   +10 more
europepmc   +1 more source

Dysfunction of the plasmacytoid dendritic cells in enterovirus 71-induced HFMD affecting children. [PDF]

BMC Immunol
He XL, Zhou YT, Liu YM, Wu JY, Liu XN, Yi Q, Feng XX, Yu J, Li L.   +8 more
europepmc   +1 more source

BDCA2 plays a central role in the binding, internalization and response of plasmacytoid dendritic cells to vidutolimod. [PDF]

Front Immunol
Lemke-Miltner CD, Blackwell SE, Yin C, Fischer TD, Weiner GJ.   +4 more
europepmc   +1 more source

Chromatin-mediated anticipatory control of type I interferon production in plasmacytoid dendritic cells. [PDF]

Immunity
Adams NM, Galitsyna A, Tiniakou I, Esteva E, Ra AC, Ullrich S, Yeung ST, Tan Y, Pucella JN, Dolgalev I, Levy DE, Khanna KM, Solovei I, Mirny LA, Reizis B.   +14 more
europepmc   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, Volume 2, Issue 2, June 2026.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source