Results 181 to 190 of about 45,338 (267)

Circulating Plasmacytoid Dendritic Cells Are Numerically and Functionally Deficient in Trauma Patients. [PDF]

J Innate Immun
Park KJ, Jin HM, Cho YN, Kim JC, Kee SJ, Jo YG, Park YW.   +6 more
europepmc   +1 more source

Comprehensive Integrated Single‐Cell and Spatial Transcriptomics Unveil the Dynamic Landscape of Betel Nut‐Associated Oral Mucosal Carcinogenesis and Its Tumor Microenvironment

MedComm, Volume 7, Issue 6, June 2026.
ABSTRACT Betel nut chewing is a major etiological factor for oral squamous cell carcinoma (OSCC), yet its mechanistic underpinnings remain poorly defined. Here, we performed single‐cell RNA sequencing and spatial transcriptomics from six OSCC patients to comprehensively dissect the tumor microenvironment (TME) dynamics and cellular heterogeneity ...
Wei Dong, Shuojin Huang, Yijun Wu, Congyuan Cao, Jiaxue Li, Qianting He, Anxun Wang   +6 more
wiley   +1 more source

Spatiotemporal Regulation of Ligand Trafficking and TLR9 Activation by PIEZO1 in Human Plasmacytoid Dendritic Cells. [PDF]

Research (Wash D C)
Pattanayak S, Raychaudhuri D, Bandopadhyay P, Mukhopadhyay U, Mandal T, Liu CSC, Kalidas N, Roychowdhury S, Chattopadhyay K, Ashish F, Sinha B, Ganguly D.   +11 more
europepmc   +1 more source

Cross‐Compartment Multimodal Analyses Reveal Differences in IL2‐STAT5 Signaling Associated With Asthma in Individuals From Diverse Backgrounds

MedComm, Volume 7, Issue 6, June 2026.
Cross‐compartment multimodal analyses reveal that under both healthy and asthmatic conditions, self‐reported African American (AA) individuals are linked to upregulation of IL2‐STAT5 signaling compared with self‐reported European American (EA) individuals, which is linked to enhanced T cell activation and recruitment during asthma.
Duan Ni, Ralph Nanan
wiley   +1 more source

Spatially resolved single-cell landscape of tumor immunotypes reveals the central role of interferon signaling and plasmacytoid dendritic cells in triple-negative breast cancer. [PDF]

J Immunother Cancer
Liu Y, Carter JM, Ma Y, Deshmukh SK, Sledge GW, Balko JM, Kachergus JM, Shi J, Gregory M, Gong J, Joensuu H, Perez EA, Stover D, Carey L, Sikov WM, Leon-Ferre R, Knutson KL, Boughey JC, Ingle JN, Kalari KR, Couch FJ, Asmann YW, Goetz MP, Thompson EA, Chumsri S.   +24 more
europepmc   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Reduced Type-I Interferon by Plasmacytoid Dendritic Cells and Asthma in School-Aged Children. [PDF]

Allergy
Coenen I, Jones AC, White AA, Takashima M, Lee WR, Wong MD, Vilcins D, Kadolsky U, Cheema AS, Saxena A, Bosco A, Grimwood K, Sly PD, Strickland DH, Leffler J.   +14 more
europepmc   +1 more source

Single‐Cell Analysis Identifies LYPD6B as a Tumor‐Intrinsic Candidate Associated With Immunotherapy Nonresponse in Breast Cancer

Thoracic Cancer, Volume 17, Issue 11, June 2026.
LYPD6B is a tumor‐intrinsic mediator of immune evasion and resistance to PD‐(L)1 therapy in breast cancer; targeting LYPD6B may improve immunotherapy efficacy. ABSTRACT Immune checkpoint blockade (ICB) induces durable responses in a subset of breast cancer patients, yet many show limited benefit from anti‐PD‐1/PD‐L1 therapy.
Yifei Wang, Haiwei Quan, Zhiguang Xu, Yixiang Wang, Zhibin Wang   +4 more
wiley   +1 more source

A Perplexing Predominance of Plasmacytoid Dendritic Cells: Chronic Myelomonocytic Leukemia Initially Considered on a Lymph Node Biopsy. [PDF]

EJHaem
Harris J, Fenu E, Bagg A.
europepmc   +1 more source

Immunosenescence and Vaccine Efficacy in Aging: Dynamic Interplay of Gut Microbiota and mTOR Signaling Pathways

Aging Cell, Volume 25, Issue 6, June 2026.
Aging impairs vaccine efficacy through gut microbiota dysbiosis and mTOR hyperactivation, which together drive inflammaging and weaken immune memory. This review highlights the bidirectional microbiota–mTOR axis and proposes that combining mTOR inhibitors with microbiota modulation offers a promising strategy to enhance vaccine responses in older ...
Jiaxuan Li, Yuhong Zhang, Daijun Yu, Jianhua Li, Keda Chen, Lisheng Chu   +5 more
wiley   +1 more source