Results 181 to 190 of about 4,506,026 (263)

Lysosomal Dysfunction Is Associated With Intervertebral Disc Degeneration: Multiomics and Machine Learning Identify Molecular Subtypes and Hub Genes

The Journal of Gene Medicine, Volume 28, Issue 9, September 2026.
Intervertebral disc degeneration (IVDD) is linked to lysosomal dysfunction, impaired autophagic degradation, and cellular senescence. Integrating bulk and single‐cell transcriptomics with machine learning, this study identified two lysosome‐related molecular subtypes and four hub genes: HYAL1, MMD, PLD3, and ANK3.
Yang Yang, Hong Li, Yixuan Ou, Yaping Yu, Kaiqiang Sun, Shixing Chen, Chenglong Ji   +6 more
wiley   +1 more source

BDCA2 plays a central role in the binding, internalization and response of plasmacytoid dendritic cells to vidutolimod. [PDF]

Front Immunol
Lemke-Miltner CD, Blackwell SE, Yin C, Fischer TD, Weiner GJ.   +4 more
europepmc   +1 more source

Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang, Yin Zhu, Fang Xu, Yongjing Liu, Yuan Li, Ling Yuan, Liqin Wei, Bo Huang, Yan Chen, Pei Huang, Zuochen Du   +10 more
wiley   +1 more source

Chromatin-mediated anticipatory control of type I interferon production in plasmacytoid dendritic cells. [PDF]

Immunity
Adams NM, Galitsyna A, Tiniakou I, Esteva E, Ra AC, Ullrich S, Yeung ST, Tan Y, Pucella JN, Dolgalev I, Levy DE, Khanna KM, Solovei I, Mirny LA, Reizis B.   +14 more
europepmc   +1 more source

Inflammatory Bowel Disease: Mechanisms and Therapeutic Advances

MedComm, Volume 7, Issue 9, September 2026.
Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a rising, multifactorial chronic disorder driven by dysregulated mucosal immunity in genetically susceptible individuals and influenced by environmental and microbial factors.
Andrea Papait, Anna Cargnoni, Franco Scaldaferri, Loris Lopetuso, Antonietta Rosa Silini, Ornella Parolini   +5 more
wiley   +1 more source

Circulating Plasmacytoid Dendritic Cells Are Numerically and Functionally Deficient in Trauma Patients. [PDF]

J Innate Immun
Park KJ, Jin HM, Cho YN, Kim JC, Kee SJ, Jo YG, Park YW.   +6 more
europepmc   +1 more source

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao, Jinxiu Qian, Qiqiong Liu, Wanting Ye, Ying Xing, Xiuyun Bai, Rongjun Deng, Jue Yang, Cheng Lu, Cheng Xiao, Yuanyan Liu   +10 more
wiley   +1 more source

Spatiotemporal Regulation of Ligand Trafficking and TLR9 Activation by PIEZO1 in Human Plasmacytoid Dendritic Cells. [PDF]

Research (Wash D C)
Pattanayak S, Raychaudhuri D, Bandopadhyay P, Mukhopadhyay U, Mandal T, Liu CSC, Kalidas N, Roychowdhury S, Chattopadhyay K, Ashish F, Sinha B, Ganguly D.   +11 more
europepmc   +1 more source

Tissue‐Resident Macrophage in Inflammation and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang, Jiangbo Fan, Wenyi Liu, Di Liu, Rui Wang, Yuanyang Wang, Jianhui Sun, Huacai Zhang, Qingli Cai, Zhe Xu, Fang Xu, Jianxin Jiang, Zhen Wang, Ling Zeng   +13 more
wiley   +1 more source

Spatially resolved single-cell landscape of tumor immunotypes reveals the central role of interferon signaling and plasmacytoid dendritic cells in triple-negative breast cancer. [PDF]

J Immunother Cancer
Liu Y, Carter JM, Ma Y, Deshmukh SK, Sledge GW, Balko JM, Kachergus JM, Shi J, Gregory M, Gong J, Joensuu H, Perez EA, Stover D, Carey L, Sikov WM, Leon-Ferre R, Knutson KL, Boughey JC, Ingle JN, Kalari KR, Couch FJ, Asmann YW, Goetz MP, Thompson EA, Chumsri S.   +24 more
europepmc   +1 more source