Plasmalogen Replacement Therapy [PDF]
Membranes, 2021 Plasmalogens, a subclass of glycerophospholipids containing a vinyl-ether bond, are one of the major components of biological membranes. Changes in plasmalogen content and molecular species have been reported in a variety of pathological conditions ...
José Carlos Bozelli, Richard Epand
exaly +6 more sources
Quantitative and Comparative Investigation of Plasmalogen Species in Daily Foodstuffs
Foods, 2021 Plasmalogens are an animal-derived functional phospholipid increasingly known as a safe and effective nutritional ingredient, however, the quantitation and comparison of plasmalogen species in foods is limited.
Zhen Chen, Yue Wu, Hirotoshi Fuda
exaly +4 more sources
Plasmalogen as a Bioactive Lipid Drug: From Preclinical Research Challenges to Opportunities in Nanomedicine [PDF]
FASEB BioAdvancesPlasmalogens are natural glycerophospholipids that account for approximately 15%–20% (mol%) of human tissues' cellular membrane phospholipid composition.
Yu Wu +3 more
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Plasmalogen Profiling in Porcine Brain Tissues by LC-MS/MS
Foods, 2023 Plasmalogen, a functional glycerophospholipid, is known for its beneficial nutritional effects, such as anti-oxidation and anti-inflammation. As the porcine brain is a plasmalogen-rich resource, this study aimed to explore its potential for plasmalogen ...
Yue Wu +4 more
doaj +2 more sources
Characterization of plasmalogen production in facultative anaerobic bacteria and aerobic synthesis in recombinant Escherichia coli expressing anaerobic bacterium-derived plasmalogen synthase genes [PDF]
Applied and Environmental MicrobiologyPlasmalogens are glycerophospholipids with vital physiological functions, conferring antioxidant properties and contributing to membrane stabilization.
Rei Irimajiri +9 more
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Regulation of plasmalogen metabolism and traffic in mammals: The fog begins to lift
Frontiers in Cell and Developmental Biology, 2022 Due to their unique chemical structure, plasmalogens do not only exhibit distinct biophysical and biochemical features, but require specialized pathways of biosynthesis and metabolization.
Katrin Watschinger +2 more
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Modulation of endogenous plasmalogens by genetic ablation of lysoplasmalogenase (Tmem86b) in mice [PDF]
Journal of Lipid ResearchPlasmalogens are a distinct subclass of glycerophospholipids that exhibit unique structural features, notably possessing a vinyl ether linkage at the sn1 position of the glycerol backbone. These specialized lipids play crucial roles in various biological
Sudip Paul +9 more
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Metabolomic Profiling Reveals Brain Lipid Alterations in PEX7-Deficient Models of Rhizomelic Chondrodysplasia Punctata [PDF]
BiomoleculesRhizomelic chondrodysplasia punctata type 1 (RCDP1) is a peroxisomal disorder characterized by skeletal shortening, intellectual disability, seizures, cataracts, and reduced lifespans. RCDP1 is caused by biallelic loss-of-function variants in PEX7, which
Riya Sankhe +8 more
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Lipid pathways connecting maternal BMI with infant obesity risk [PDF]
Scientific ReportsMaternal obesity is a key determinant of infant health, increasing early-life obesity risk. Lipids are mechanistically linked to obesity and may mediate intergenerational transfer, by influencing foetal or infant lipids. Using the Barwon Infant Study, we
Alexandra D. George +13 more
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First‐In‐Human Safety, Tolerability, and Pharmacokinetics of PPI‐1011, a Synthetic Plasmalogen Precursor [PDF]
Clinical and Translational SciencePPI‐1011 is a synthetic plasmalogen precursor designed to augment plasmalogen levels in patients with Rhizomelic chondrodysplasia punctata (RCDP), an ultra‐rare genetic disorder caused by a plasmalogen deficiency that results in significant physical and ...
Tara Smith +2 more
doaj +2 more sources