Results 11 to 20 of about 5,522 (198)

Dietary plasmalogen increases erythrocyte membrane plasmalogen in rats [PDF]

Lipids in Health and Disease, 2012
Background Many disorders with plasmalogen deficiency have been reported. Replenishment or replacement of tissue plasmalogens of these disorders would be beneficial to the patients with these disorders, but effects of dietary plasmalogen on mammals have ...
Mawatari Shiro, Katafuchi Toshihiko, Miake Kiyotaka, Fujino Takehiko   +3 more
doaj   +5 more sources

Time-Dependent Analysis of Plasmalogens in the Hippocampus of an Alzheimer’s Disease Mouse Model: A Role of Ethanolamine Plasmalogen

Brain Sciences, 2021
Plasmalogens are alkenyl-acyl glycerophospholipids and decreased in post-mortem Alzheimer’s disease (AD) brains. The aim of this study is to investigate the time-dependent changes of plasmalogens in the hippocampus of an AD model mouse (J20). Plasmalogen
Abul Kalam Azad, Abdullah Md. Sheikh, Md. Ahsanul Haque, Harumi Osago, Hiromichi Sakai, Abu Zaffar Shibly, Shozo Yano, Makoto Michikawa, Shahdat Hossain, Shatera Tabassum, Garu A., Xiaojing Zhou, Yuchi Zhang, Atsushi Nagai   +13 more
doaj   +2 more sources

Human and great ape red blood cells differ in plasmalogen levels and composition [PDF]

Lipids in Health and Disease, 2011
Background Plasmalogens are ether phospholipids required for normal mammalian developmental, physiological, and cognitive functions. They have been proposed to act as membrane antioxidants and reservoirs of polyunsaturated fatty acids as well as ...
Ely John J, Lee D Rick, Siegmund Kimberly D, Ramaswamy Krishna, Moser Hugo W, Watkins Paul A, Steinberg Steven J, Moser Ann B, Ryder Oliver A, Hacia Joseph G   +9 more
doaj   +2 more sources

Alkyl-glycerol rescues plasmalogen levels and pathology of ether-phospholipid deficient mice. [PDF]

PLoS ONE, 2011
A deficiency of plasmalogens, caused by impaired peroxisomal metabolism affects normal development and multiple organs in adulthood. Treatment options aimed at restoring plasmalogen levels may be relevant for the therapy of peroxisomal and non ...
Pedro Brites, Ana Sofia Ferreira, Tiago Ferreira da Silva, Vera F Sousa, Ana R Malheiro, Marinus Duran, Hans R Waterham, Myriam Baes, Ronald J A Wanders   +8 more
doaj   +4 more sources

Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice [PDF]

Metabolites, 2021
Plasmalogens or alkenylphospholipids are a sub-class of glycerophospholipids with numerous biological functions and are thought to have protective effects against metabolic disease.
Sudip Paul, Aliki A. Rasmiena, Kevin Huynh, Adam Alexander T. Smith, Natalie A. Mellett, Karin Jandeleit-Dahm, Graeme I. Lancaster, Peter J. Meikle   +7 more
doaj   +3 more sources

In vitro and in vivo plasmalogen replacement evaluations in rhizomelic chrondrodysplasia punctata and Pelizaeus-Merzbacher disease using PPI-1011, an ether lipid plasmalogen precursor [PDF]

Lipids in Health and Disease, 2011
Background Childhood peroxisomal disorders and leukodystrophies are devastating diseases characterized by dysfunctional lipid metabolism. Plasmalogens (ether glycerophosphoethanolamine lipids) are decreased in these genetic disorders. The biosynthesis of
Wood Paul L, Khan M Amin, Smith Tara, Ehrmantraut Greg, Jin Wei, Cui Wei, Braverman Nancy E, Goodenowe Dayan B   +7 more
doaj   +2 more sources

Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study [PDF]

Lipids in Health and Disease, 2010
Background Disrupted cholesterol regulation leading to increased circulating and membrane cholesterol levels is implicated in many age-related chronic diseases such as cardiovascular disease (CVD), Alzheimer's disease (AD), and cancer.
Su-Myat Khine K, Khan Mohamed A, Ritchie Shawn A, Jayasinghe Dushmanthi, Ma Hong, Ahiahonu Pearson WK, Mankidy Rishikesh, Wood Paul L, Goodenowe Dayan B   +8 more
doaj   +2 more sources

Plasmalogen Augmentation Reverses Striatal Dopamine Loss in MPTP Mice. [PDF]

PLoS ONE, 2016
Plasmalogens are a class of glycerophospholipids shown to play critical roles in membrane structure and function. Decreased plasmalogens are reported in the brain and blood of Parkinson's disease (PD) patients.
Edith Miville-Godbout, Mélanie Bourque, Marc Morissette, Sara Al-Sweidi, Tara Smith, Asuka Mochizuki, Vijitha Senanayake, Dushmanthi Jayasinghe, Li Wang, Dayan Goodenowe, Thérèse Di Paolo   +10 more
doaj   +2 more sources

Plasmalogen deficiency is associated with major polyunsaturated fatty acid (PUFA) alterations in the mouse retina☆

Oilseeds and fats, crops and lipids
Background: Plasmalogens are ether-phospholipids that play essential roles in cell physiology. They serve as reservoirs for polyunsaturated fatty acids (PUFAs), which regulate retinal vascular development. Plasmalogen deficiency is associated with severe
Karadayi Rémi, Gregoire Stéphane, Loriot Bénédicte, Martine Lucy, Bron Alain M., Gabrielle Pierre-Henry, Creuzot-Garcher Catherine, Acar Niyazi   +7 more
doaj   +2 more sources

Determination of Plasmalogen Molecular Species in Hen Eggs

Molecules
(1) Background: Plasmalogens are vinyl ether-type glycerophospholipids that are characteristically distributed in neural tissues and are significantly reduced in the brains of individuals with dementia compared to those in healthy subjects, suggesting a ...
Taiki Miyazawa, Ohki Higuchi, Ryosuke Sogame, Teruo Miyazawa   +3 more
doaj   +2 more sources