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Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review
Membranes, 2023 Plasmalogens are a unique family of cellular glycerophospholipids that contain a vinyl-ether bond. The synthesis of plasmalogens is initiated in peroxisomes and completed in the endoplasmic reticulum.
Yukio Fujiki, Masanori Honsho
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Plasmalogens as biomarkers and therapeutic targets. [PDF]
J Lipid ResPlasmalogens are structurally similar to phosphatidylcholine or phosphatidylethanolamine but differ at the Sn-1 position, containing a vinyl-ether instead of an ester bond. Reduced levels of plasmalogens in circulation or in cell membranes are associated
Curran CS, Remaley AT, Torabi-Parizi P.
europepmc +2 more sources
Orally administered scallop-derived plasmalogens improve cognitive function in healthy middle-aged and older adults: a randomized, double-blind, placebo-controlled trial. [PDF]
Front NutrBackgroundPlasmalogens (Pls) are ether phospholipids enriched in the brain that help maintain synaptic integrity and support cognitive function. However, evidence of their cognitive benefits in otherwise healthy individuals remains limited.
Fukuchi M +4 more
europepmc +2 more sources
Plasmalogens in Innate Immune Cells: From Arachidonate Signaling to Ferroptosis
BiomoleculesPolyunsaturated fatty acids such as arachidonic acid are indispensable components of innate immune signaling. Plasmalogens are glycerophospholipids with a vinyl ether bond in the sn-1 position of the glycerol backbone instead of the more common sn-1 ...
María A Balboa, Jesús Balsinde
exaly +3 more sources
Plasmalogen as a Bioactive Lipid Drug: From Preclinical Research Challenges to Opportunities in Nanomedicine. [PDF]
FASEB BioadvPlasmalogens are natural glycerophospholipids that account for approximately 15%–20% (mol%) of human tissues' cellular membrane phospholipid composition.
Wu Y, Deng Y, Angelov B, Angelova A.
europepmc +2 more sources
Frontiers in Molecular Biosciences, 2022 Plasmalogens are a subclass of glycerophospholipid containing vinyl-ether bond at the sn-1 position of glycerol backbone. Ethanolamine-containing plasmalogens (plasmalogens) are major constituents of cellular membranes in mammalian cells and de novo ...
Masanori Honsho +4 more
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Potential Role of Plasmalogens in the Modulation of Biomembrane Morphology
Frontiers in Cell and Developmental Biology, 2021 Plasmalogens are a subclass of cell membrane glycerophospholipids that typically include vinyl- ether bond at the sn-1 position and polyunsaturated fatty acid at the sn-2 position. They are highly abundant in the neuronal, immune, and cardiovascular cell
Zakaria A. Almsherqi
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Plasmalogens in bacteria, sixty years on
Frontiers in Molecular Biosciences, 2022 The presence of plasmalogens in bacteria has been known for 60 years. The recent discovery of two genes encoding reductases that convert diacyl lipids to 1-alk-1′-enyl 2-acyl lipids has confirmed the derivation of plasmalogens from the corresponding ...
Howard Goldfine
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Frontiers in Molecular Biosciences, 2022 Ethanolamine-containing alkenyl ether glycerophospholipids, plasmalogens, are major cell membrane components of mammalian cells that activate membrane protein receptors such as ion transporters and G-protein coupled receptors.
Masanori Honsho +2 more
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Advances in the Biosynthetic Pathways and Application Potential of Plasmalogens in Medicine
Frontiers in Cell and Developmental Biology, 2020 Plasmalogens are a special class of polar glycerolipids containing a vinyl-ether bond and an ester bond at sn-1 and sn-2 positions of the glycerol backbone, respectively.
Yulong Zhou +7 more
doaj +1 more source