Results 41 to 50 of about 63,107 (284)
Cationic Peptoids for Systemic In Vivo Cartilage‐Targeting
Advanced Science, EarlyView.Systemically‐dosed Cy5‐labeled cationic peptoid probe (NlysO)7 (yellow) binds to the cartilage's glycosaminoglycan content in vivo across the entire body of a neonatal mouse imaged by light sheet fluorescence microscopy, revealing fluorescence uptake in generic cartilage as well as the developing and ossifying bones.
Chaonan Zhang +6 more
wiley +1 more source
BioTechniques, 1996 MatrigelTM, a basement membrane (BM) extract of the Engelbreth-Holm-Swarm (EHS) sarcoma, used in tumor invasion assays, was found to contain plasminogen.
A.R. Farina +6 more
doaj +1 more source
eLife, 2020 Osteocalcin (OCN) is an osteoblast-derived hormone with pleiotropic physiological functions. Like many peptide hormones, OCN is subjected to post-translational modifications (PTMs) which control its activity.
Omar Al Rifai +7 more
doaj +1 more source
A novel mechanism controlling the growth of hemostatic thrombi [PDF]
The Ukrainian Biochemical Journal, 2013 Current knowledge of the mechanisms of blood coagulation does not provide an answer to one pivotal question: why is, in contrast to a pathological thrombus, the growth of normal hemostatic clot after blood vessel injury suddenly terminated?
V. K. Lishko +3 more
doaj +1 more source
Cyclo19,31[D-Cys19]-uPA19-31 is a potent competitive antagonist of the interaction of urokinase-type plasminogen activator with its receptor (CD87) [PDF]
, 2001 Urokinase-type plasminogen activator (uPA) represents a central molecule in pericellular proteolysis and is implicated in a variety of physiological and pathophysiological processes such as tissue remodelling, wound healing, tumor invasion, and ...
Arroyo de Prada, Nuria +10 more
core +1 more source
Tendinopathy: The Interplay between Mechanical Stress, Inflammation, and Vascularity
Advanced Science, EarlyView.This review explores the complex and self‐reinforcing cycle of mechanical stress, inflammation, and altered vascularity in tendinopathy—a common, painful tendon disorder. It integrates current findings on cellular, molecular, and biomechanical mechanisms, highlighting how mechanical overload, inflammatory signals, and abnormal blood vessel behavior ...
Renate Gehwolf +5 more
wiley +1 more source
Ocriplasmin in the treatment of vitreomacular traction in a patient with central retinal vein occlusion. a case report [PDF]
, 2018 Aim: To investigate the efficacy of intravitreal injection of ocriplasmin (JETREA®) in the treat-ment of vitreomacular traction (VMT). Materials and Methods: An 81-year-old man with VMT associated with central retinal vein occlusion in his left eye, was ...
Antonio Esposito, Raffaele +3 more
core +2 more sources
The Evolution of Functional Amyloids and Their Impact on Host–Microbe Interactions
Advanced Science, EarlyView.This review describes functional amyloids and highlights the importance of structural repetition and molecular mimicry that distinguish the amyloid fold. The authors describe how amyloid can be the last universal common ancestor of protein folds. The authors also discuss how microbes utilize functional amyloids and how the structural characteristics of
Divya Kolli +3 more
wiley +1 more source
BMJ Open, 2019 ObjectivesPre-eclampsia (PE) is characterised by renal glomerular endotheliosis and injury to the glomerular filtration barrier with proteinuria. Patients with PE display aberrant filtration of the plasma proenzyme plasminogen which is activated, in the ...
Lise H Nielsen +6 more
doaj +1 more source
Aggregate, EarlyView.Tau amyloid corona‐shelled nanoparticles (TACONs) were synthesized by incubating gold nanoparticles (AuNPs) with tau monomers that had been pre‐reacted with heparin. These TACONs represent a promising high‐throughput screening platform for identifying tau oligomer degraders as potential therapeutic agents for Alzheimer's disease.
Hyo Gi Jung +12 more
wiley +1 more source