Results 41 to 50 of about 81,533 (325)

Markers of thrombogenesis and fibrinolysis and their relation to inflammation and endothelial activation in patients with idiopathic pulmonary arterial hypertension.

PLoS ONE, 2013
BackgroundChronic anticoagulation is a standard of care in idiopathic pulmonary arterial hypertension (IPAH). However, hemostatic abnormalities in this disease remain poorly understood.
Grzegorz Kopeć, Deddo Moertl, Sabine Steiner, Ewa Stępień, Tomasz Mikołajczyk, Jakub Podolec, Marcin Waligóra, Jakub Stępniewski, Lidia Tomkiewicz-Pająk, Tomasz Guzik, Piotr Podolec   +10 more
doaj   +1 more source

Decoding the role of angiopoietin-like protein 4/8 complex–mediated plasmin generation in the regulation of LPL activity

Journal of Lipid Research, 2023
After feeding, adipose tissue lipoprotein lipase (LPL) activity should be maximized, therefore the potent LPL-inhibitory activity of angiopoietin-like protein 4 (ANGPTL4) must be blocked by ANGPTL8 through formation of ANGPTL4/8 complexes.
Yan Q. Chen, Eugene Y. Zhen, Anna M. Russell, Mariam Ehsani, Robert W. Siegel, Yuewei Qian, Robert J. Konrad   +6 more
doaj   +1 more source

Effect of Plasmin on Laminin and Fibronectin During Plasmin-Assisted Vitrectomy [PDF]

Archives of Ophthalmology, 2005
To determine whether plasmin will cleave the laminin and fibronectin located at the vitreoretinal junction during plasmin-assisted vitrectomy.Western blot analyses were performed with antilaminin or anti-fibronectin antibodies on the internal limiting membranes collected from patients with macular holes or cystoid macular edema who underwent vitrectomy
Hiroko Terasaki, Yuji Nishizawa, Yozo Miyake, Tetsu Asami, Makoto Nakamura, Ai Uemura, Shu Kachi   +6 more
openaire   +3 more sources

Potent, Selective, Allosteric Inhibition of Human Plasmin by Sulfated Non-Saccharide Glycosaminoglycan Mimetics.

Journal of Medicinal Chemistry, 2017
Although plasmin inhibitors could be used in multiple disorders, their use has been restricted to preventing blood loss in hemostatic dysregulation because of poor efficacy and adverse effects of current agents.
Daniel K. Afosah, Rami A. Al‐Horani, N. Sankaranarayanan, U. Desai   +3 more
semanticscholar   +1 more source

Ocriplasmin in the treatment of vitreomacular traction in a patient with central retinal vein occlusion. a case report [PDF]

, 2018
Aim: To investigate the efficacy of intravitreal injection of ocriplasmin (JETREA®) in the treat-ment of vitreomacular traction (VMT). Materials and Methods: An 81-year-old man with VMT associated with central retinal vein occlusion in his left eye, was ...
Antonio Esposito, Raffaele, Mannino, Giuseppe, Rosati, Alessandra, Scuderi, Gianluca   +3 more
core   +2 more sources

Enhanced thrombin and plasmin generation profiles in alpha-2-antiplasmin–deficient patients: Data from the Rare Bleeding disorders in the Netherlands study

Research and Practice in Thrombosis and Haemostasis
Background: α2-Antiplasmin (A2AP) deficiency is a rare and often unidentified disorder characterized by increased fibrinolysis and subsequent bleeding. Global hemostasis assays may increase insight into the altered coagulation and fibrinolysis in these ...
Bauke Haisma, Sanna R. Rijpma, Marjon H. Cnossen, Paul L. den Exter, Ilmar C. Kruis, Karina Meijer, Laurens Nieuwenhuizen, Nick van Es, Roger E.G. Schutgens, Nicole M.A. Blijlevens, Waander L. van Heerde, Saskia E.M. Schols   +11 more
doaj   +1 more source

Plasmin as a complement C5 convertase [PDF]

EBioMedicine, 2016
Both the complement and coagulation/fibrinolytic systems are essential components of the host defense system that evolved early in the evolution of vertebrates (Krem and Di Cera, 2002). While the coagulation and fibrinolytic systems are necessary for maintenance of the integrity of the vasculature, these systems also respond to infections, and together
John Morser, Lawrence L.K. Leung
openaire   +4 more sources

Synthesis of human plasminogen by the liver [PDF]

, 1980
Genetic types of plasminogen were determined from a donor and a recipient before and after hepatic homotransplantation. Examination of the plasminogen types demonstrated that the liver is the principal site of synthesis of human plasminogen.
Alper, CA, Levey, R, Marcus, D, Raum, D, Starzl, TE, Taylor, PD   +5 more
core   +1 more source

Effects of Plasmin on von Willebrand Factor and Platelets: A Narrative Review

TH Open, 2018
Plasmin is the major fibrinolytic protease responsible for dissolving thrombi by cleavage of its primary substrate fibrin. In addition, emerging evidence points to other roles of plasmin: (1) as a back-up for ADAMTS13 in proteolysis of ultra-large von ...
Lisa N. van der Vorm, Jasper A. Remijn, Bas de Laat, Dana Huskens   +3 more
doaj   +1 more source

Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications

Advanced Healthcare Materials, EarlyView.
This review discusses the bioconjugation of novel materials grouped under “biological”, “hybrid” and “synthetic” categories. Medical applications ranging from cancer therapy and diagnostics to optogenetics and tissue engineering are explored, and conjugation trends are highlighted as a general guide. The review concludes with a comparison of techniques
Ellie Martin, Sean P. Doidge, Eiman Aleem, Suela Kellici, Steven Dunn, Claire Atkinson, Philip D. Howes   +6 more
wiley   +1 more source