Results 41 to 50 of about 63,325 (266)

Effect of Plasmin on Laminin and Fibronectin During Plasmin-Assisted Vitrectomy [PDF]

Archives of Ophthalmology, 2005
To determine whether plasmin will cleave the laminin and fibronectin located at the vitreoretinal junction during plasmin-assisted vitrectomy.Western blot analyses were performed with antilaminin or anti-fibronectin antibodies on the internal limiting membranes collected from patients with macular holes or cystoid macular edema who underwent vitrectomy
Hiroko Terasaki, Yuji Nishizawa, Yozo Miyake, Tetsu Asami, Makoto Nakamura, Ai Uemura, Shu Kachi   +6 more
openaire   +3 more sources

Effects of Plasmin on von Willebrand Factor and Platelets: A Narrative Review

TH Open, 2018
Plasmin is the major fibrinolytic protease responsible for dissolving thrombi by cleavage of its primary substrate fibrin. In addition, emerging evidence points to other roles of plasmin: (1) as a back-up for ADAMTS13 in proteolysis of ultra-large von ...
Lisa N. van der Vorm, Jasper A. Remijn, Bas de Laat, Dana Huskens   +3 more
doaj   +1 more source

Identification of Plasminogen in MatrigelTM and Its Activation by Reconstitution of This Basement Membrane Extract

BioTechniques, 1996
MatrigelTM, a basement membrane (BM) extract of the Engelbreth-Holm-Swarm (EHS) sarcoma, used in tumor invasion assays, was found to contain plasminogen.
A.R. Farina, A. Tiberio, A. Tacconelli, L. Cappabianca, A. Gulino, A. Gulino, A.R. Mackay   +6 more
doaj   +1 more source

Stability of the octameric structure affects plasminogen-binding capacity of streptococcal enolase. [PDF]

PLoS ONE, 2015
Group A Streptococcus (GAS) is a human pathogen that has the potential to cause invasive disease by binding and activating human plasmin(ogen). Streptococcal surface enolase (SEN) is an octameric α-enolase that is localized at the GAS cell surface.
Amanda J Cork, Daniel J Ericsson, Ruby H P Law, Lachlan W Casey, Eugene Valkov, Carlo Bertozzi, Anna Stamp, Blagojce Jovcevski, J Andrew Aquilina, James C Whisstock, Mark J Walker, Bostjan Kobe   +11 more
doaj   +1 more source

Effect of dsRNA on Mesangial Cell Synthesis of Plasminogen Activator Inhibitor Type 1 and Tissue Plasminogen Activator [PDF]

, 2009
Background/Aims: Viral infections are a major problem worldwide and many of them are complicated by virally induced glomerulonephritides. Progression of kidney disease to renal failure is mainly attributed to the development of renal fibrosis ...
Merkle, Monika, Ribeiro, Andrea, Roeder, Maximilian, Sauter, Matthias, Wörnle, Markus   +4 more
core   +1 more source

Glaucoma is associated with plasmin proteolytic activation mediated through oxidative inactivation of neuroserpin

Scientific Reports, 2017
Neuroserpin is a serine protease inhibitor that regulates the activity of plasmin and its activators in the neuronal tissues. This study provides novel evidence of regulatory effect of the neuroserpin on plasmin proteolytic activity in the retina in ...
Vivek Gupta, Mehdi Mirzaei, Veer Bala Gupta, Nitin Chitranshi, Yogita Dheer, Roshana Vander Wall, Mojdeh Abbasi, Yuyi You, Roger Chung, Stuart Graham   +9 more
doaj   +1 more source

Characterizing plasmin-induced lag phase and application of PDMS microfluidics to detection of fibrinolytic activity [PDF]

, 2018
Physical trauma is responsible for over six million deaths annually, and of these roughly 40 percent result from acute traumatic coagulopathy (ATC) occurring in the first few hours of incidence. Patients who have developed ATC have significantly improved
Ghani, Naveed
core  

Expression of the ???6 integrin promotes migration and invasion in squamous carcinoma cells [PDF]

, 2001
The integrin αvβ6 is a fibronectin receptor whose expression is not detectable on normal oral epithelium but is increased significantly in healing and in oral epithelial dysplasia and oral squamous cell carcinoma, suggesting it may promote changes ...
Agrez, Agrez, Ben-Ze'Ev, Breuss, Brunner, Clark, Clark, Damsky, Danen, Downer, Frisch, Giancotti, Haapasalmi, Hall, Hamidi, Hindle, Huang, Hynes, Johnson, Jones, Jones, Jones, Juliano, Koretz, Larjava, Marshall, Marshall, Morgenstern, Niu, Parkin, Peltonen, Pignatelli, Prime, Sonnenberg, Sugiyama, Thomas, Weinacker, Yamada   +37 more
core   +1 more source

Plasmin as a complement C5 convertase [PDF]

EBioMedicine, 2016
Both the complement and coagulation/fibrinolytic systems are essential components of the host defense system that evolved early in the evolution of vertebrates (Krem and Di Cera, 2002). While the coagulation and fibrinolytic systems are necessary for maintenance of the integrity of the vasculature, these systems also respond to infections, and together
John Morser, Lawrence L.K. Leung
openaire   +4 more sources

Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis

Advanced Science, EarlyView.
In this study, a mechanical biomimetic nanocomposite is developed, guided by photoacoustic imaging, to achieve highly efficient and safe thrombolysis through the synergistic effects of photothermal therapy and pharmacological intervention. Most notably, the nanoparticle improves the microenvironment of arterial thrombi, marked by high shear stress and ...
Ying Li, Qi Xiang, Yan Zhang, Fuxue Luo, Yunfang Wu, Haitao Ran, Yang Cao   +6 more
wiley   +1 more source