Results 21 to 30 of about 315,782 (393)
Identification of the binding site for plasminogen kringle 5 in the α-chain of fibrin(ogen) D-fragment [PDF]
The Ukrainian Biochemical Journal, 2020 The interaction of the fifth kringle of Glu-plasminogen with fibrin triggers activation and initiation of fibrinolysis, yet the site on fibrin that binds kringle 5 remains unknown.
L. G. Kapustianenko +4 more
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Phosphorylation of human plasminogen activators and plasminogen [PDF]
FEBS Letters, 1995 Plasminogen (PG), urokinase‐type plasminogen activator (u‐PA) and tissue‐type PA (t‐PA) are the main molecules involved in fibrinolysis and in many other physiological and pathological processes. In the present study we report that human t‐PA, purified from human melanoma cells, and PG, purified from human plasma, both contain P‐Tyr residues, as ...
BARLATI, Sergio +4 more
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Pathogens, 2022 Bacterial acquisition of metals from a host is an essential attribute to facilitate survival and colonization within an infected organism. Staphylococcus aureus, a bacterial pathogen of medical importance, has evolved its strategies to acquire multiple ...
Natália Salazar +5 more
doaj +1 more source
Plasminogen–receptor KT: plasminogen activation and beyond [PDF]
Journal of Thrombosis and Haemostasis, 2017 The cell surface orchestrates plasminogen activation through the concomitant binding of plasminogen and plasminogen activators to specific receptors. In this issue, Miles and colleagues describe their detailed phenotypic characterization of mice deficient in Plg-RKT, a key plasminogen receptor expressed in numerous tissues, but highly expressed by ...
M J, Flick, T H, Bugge
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Frontiers in Cardiovascular Medicine, 2021 Chronic diseases in growing children, such as autoimmune disorders, obesity, and cancer, are hallmarked by musculoskeletal growth disturbances and osteoporosis.
Heather A. Cole +22 more
doaj +1 more source
Biomedicines, 2022 Severe eosinophilic asthma is characterized by chronic airway inflammation, oxidative stress, and elevated proinflammatory cytokines, especially IL-5.
Lorenza Vantaggiato +12 more
doaj +1 more source
The Pneumococcal Protein SufC Binds to Host Plasminogen and Promotes Its Conversion into Plasmin
Microorganisms, 2023 Streptococcus pneumoniae causes otitis media, sinusitis, and serious diseases such as pneumonia and bacteremia. However, the in vivo dynamics of S. pneumoniae infections and disease severity are not fully understood.
Yoshihito Yasui +7 more
doaj +1 more source
Synthesis of human plasminogen by the liver [PDF]
, 1980 Genetic types of plasminogen were determined from a donor and a recipient before and after hepatic homotransplantation. Examination of the plasminogen types demonstrated that the liver is the principal site of synthesis of human plasminogen.
Alper, CA +5 more
core +1 more source
Plasminogen Receptors and Fibrinolysis [PDF]
International Journal of Molecular Sciences, 2021 The ability of cells to promote plasminogen activation on their surfaces is now well recognized, and several distinct cell surface proteins have been demonstrated to function as plasminogen receptors. Here, we review studies demonstrating that plasminogen bound to cells, in addition to plasminogen directly bound to fibrin, plays a major role in ...
Lindsey A. Miles +5 more
openaire +3 more sources
Frontiers in Veterinary Science, 2019 Babesia microti, an intraerythrocytic protozoa, can cause an emerging tick-borne disease—Human babesiosis. The parasite can successfully invade host red blood cells owing to the assistance of molecules expressed by babesia.
Xiangye Liu +8 more
doaj +1 more source