Results 51 to 60 of about 201,835 (360)

Cholera Vibrio Membrane Protein OmpT as an Omptin Belonging to Vibrionaceae Family

Проблемы особо опасных инфекций, 2014
Concerned are the issues related to enterobacteria omptins, their structure and functionality, as well as alternative role in pathogenesis of the infections induced by them.
B. N. Mishan’Kin, O. V. Duvanova, L. V. Romanova, E. S. Shipko, A. S. Vodop’Yanov   +4 more
doaj   +1 more source

DnaK Functions as a Moonlighting Protein on the Surface of Mycoplasma hyorhinis Cells

Frontiers in Microbiology, 2022
Mycoplasma hyorhinis is a common pathogen of swine and is also associated with various human tumors. It causes systemic inflammation, typically polyserositis and polyarthritis, in some infected pigs. However, the pathogenic mechanism of M.
Yao Li, Yao Li, Jia Wang, Jia Wang, Beibei Liu, Yanfei Yu, Yanfei Yu, Yanfei Yu, Ting Yuan, Yanna Wei, Yanna Wei, Yuan Gan, Jia Shao, Jia Shao, Guoqing Shao, Guoqing Shao, Guoqing Shao, Guoqing Shao, Zhixin Feng, Zhixin Feng, Zhixin Feng, Zhigang Tu, Qiyan Xiong, Qiyan Xiong, Qiyan Xiong, Qiyan Xiong   +25 more
doaj   +1 more source

Role of Plasminogen Activator Inhibitor Type 1 in Pathologies of Female Reproductive Diseases

International Journal of Molecular Sciences, 2017
Normal pregnancy is a state of hypercoagulability with diminishing fibrinolytic activity, which is mainly caused by an increase of plasminogen activator inhibitor type 1 (PAI-1).
Y. Ye, A. Vattai, Xi Zhang, Junyan Zhu, C. Thaler, S. Mahner, U. Jeschke, V. von Schönfeldt   +7 more
semanticscholar   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

The Deleterious Effects of Impaired Fibrinolysis on Skeletal Development Are Dependent on Fibrin(ogen), but Independent of Interlukin-6

Frontiers in Cardiovascular Medicine, 2021
Chronic diseases in growing children, such as autoimmune disorders, obesity, and cancer, are hallmarked by musculoskeletal growth disturbances and osteoporosis.
Heather A. Cole, Stephanie N. Moore-Lotridge, Stephanie N. Moore-Lotridge, Gregory D. Hawley, Richard Jacobson, Richard Jacobson, Masato Yuasa, Masato Yuasa, Leslie Gewin, Leslie Gewin, Jeffry S. Nyman, Jeffry S. Nyman, Jeffry S. Nyman, Jeffry S. Nyman, Matthew J. Flick, Matthew J. Flick, Matthew J. Flick, Jonathan G. Schoenecker, Jonathan G. Schoenecker, Jonathan G. Schoenecker, Jonathan G. Schoenecker, Jonathan G. Schoenecker, Jonathan G. Schoenecker   +22 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Hemostasis protein-coding genes, peripheral hemostasis parameters, and atherothrombosis predisposition in patients with cardiovascular disease

Кардиоваскулярная терапия и профилактика, 2011
Aim. To study the associations between polymorphic variants of hemostasis protein-coding genes, hemostasis system functioning, and atherothrombosis development in patients with cardiovascular disease (CVD). Material and methods.
G. I. Lifshits, S. T. Danilkina, E. V. Guskova, E. N. Voronina, M. L. Filipenko   +4 more
doaj   +1 more source

Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aims This study aimed to explore the relationship between stress‐induced hyperglycemia (SIH) and in‐hospital medical complications in patients with acute stroke. Methods We enrolled 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort.
Xintong Song, Yi Ju, Hongqiu Gu, Zhikai Zhu, Zixiao Li, Qian Zhang, Xingquan Zhao   +6 more
wiley   +1 more source

Interaction of plasminogen and fibrin in plasminogen activation.

Journal of Biological Chemistry, 1990
Glu1-, Lys77-, miniplasminogens, kringle 1-3, kringle 1-5A, and kringle 1-5R were able to bind with fibrin, while microplasminogen and kringle 4 did not bind significantly. Kringle 1-5A, but not kringle 1-3, effectively inhibited the binding of Glu1-, Lys77-, and miniplasminogens with fibrin.
H L, Wu, B I, Chang, D H, Wu, L C, Chang, C C, Gong, K L, Lou, G Y, Shi   +6 more
openaire   +2 more sources

Molecular Interactions of Human Plasminogen with Fibronectin-binding Protein B (FnBPB), a Fibrinogen/Fibronectin-binding Protein from Staphylococcus aureus*

Journal of Biological Chemistry, 2016
Staphylococcus aureus is a commensal bacterium that has the ability to cause superficial and deep-seated infections. Like several other invasive pathogens, S. aureus can capture plasminogen from the human host where it can be converted to plasmin by host
G. Pietrocola, G. Nobile, V. Gianotti, M. Zapotoczna, T. Foster, J. Geoghegan, P. Speziale   +6 more
semanticscholar   +1 more source