Results 161 to 170 of about 94,031 (266)

High serum urokinase-type plasminogen activator receptor correlates with sepsis-induced cardiomyopathy in sepsis patients. [PDF]

Front Med (Lausanne)
He J, Wu T, Wu G, Huang Y, Yin X, Zhang M, Fang B, Guo L.   +7 more
europepmc   +1 more source

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents

Brain and Behavior, Volume 16, Issue 6, June 2026.
In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence, Daniel Fulton, Poppy Brown, Subashini Suresh, Mark Morris, Paraskevi Goggolidou, Sree Chaithanya, Marcus Abbawy, Amelia Wild, Prashant Nasa, Niharika A. Duggal, Fang Gao‐Smith, Zubair Ahmed, Suresh Renukappa, Tonny Veenith   +14 more
wiley   +1 more source

Soluble Urokinase Plasminogen Activator Receptor (suPAR) Mediates the Impact of Diabetes on Adverse Outcomes in Coronary Artery Disease. [PDF]

Diabetes Care
Sakr SM, Desai S, Medina-Inojosa J, Liu C, Razavi AC, Yadalam AK, Ko YA, Ahmed T, Harris KA, Huang J, Yeboah R, Haroun N, Hartsfield JD, Owais M, Lodhi R, Eldaidamouni AA, Al Kasem M, Ali MK, Narayan KMV, Pasquel FJ, Tandon N, Mohan V, Quyyumi AA.   +22 more
europepmc   +1 more source

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun, Hao Shu, Qian Zhang, Jishan Zheng, Yunyan Ma, Dengwang Chen, Jidong Zhang, Tao Song   +7 more
wiley   +1 more source

Mechanical Aortic Valve Thrombosis: Treatment With Tissue Plasminogen Activator. [PDF]

JACC Case Rep
Munawar G, Gupta V, Laiq Z, Sleik K.
europepmc   +1 more source

A working model for CCN3 C‐terminal domain‐mediated transcriptional modulation of the plasminogen activation system

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Plasminogen is a circulating zymogen that is converted into active plasmin by plasminogen activators such as tissue plasminogen activator (tPA) and urokinase‐type PA (uPA). This conversion is regulated by plasminogen activator inhibitors (PAI‐1, PAI‐2) and by inhibitors of plasmin itself, maintaining a fine balance between activation and inhibition of ...
Bernard Perbal
wiley   +1 more source

Fibroblast circSamd4 promotes cardiac fibrosis via activating plasminogen activator inhibitor-1. [PDF]

Redox Biol
Chen Y, Zhang Z, Cheng Y, Chen X, Zhou J, Wei Z, Yao H, Zhang S, Kong Q, Tang H, Wu W, Zhou Z, Tang X, Liu X.   +13 more
europepmc   +1 more source

Programmed Cell Death in Chronic Rhinosinusitis

Clinical and Translational Allergy, Volume 16, Issue 6, June 2026.
ABSTRACT Chronic rhinosinusitis (CRS) is a prevalent upper respiratory condition characterized by a multifaceted etiology involving various cellular and molecular processes. In recent years, researchers have increasingly recognized the significance of different forms of programmed cell death (PCD), such as apoptosis and pyroptosis, in the pathological ...
Xingchen Liu, Junying Hu, Weigang Gan, Qi Wu, Bing Zhong, Feng Liu   +5 more
wiley   +1 more source

Soluble Urokinase Plasminogen Activator Receptor (suPAR): Role in the Risk Stratification of Potentially Infected Patients Presenting at the Emergency Department. [PDF]

Diagnostics (Basel)
Baldetti M, Velocci S, Belardi R, Di Lecce VN, Paganelli C, Fortunato NA, Ricciardulli T, Terrinoni A, Pieri M, Bernardini S, Legramante JM, Minieri M.   +11 more
europepmc   +1 more source

Toosendanin Alleviates Cerebral Ischemia/Reperfusion Injury via Inhibiting Neural Ferroptosis Through Lipid Metabolic Reprogramming in MCAO Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Post‐stroke administration of TSN significantly reduced infarct volume, neuroinflammation, and improved functional recovery of MCAO mice. TSN alleviated neural oxidative stress, lipid peroxidation, and ferroptosis in MCAO mice. TSN modulated the infiltration of immune cells in MCAO mice in vivo and T cell differentiation in vitro.
Xinyun Li, Zhiyong Zhao, Jingting Zhao, Xiangming Ye, Zhenfei Xiong, Jiejin Zhao   +5 more
wiley   +1 more source