Results 221 to 230 of about 94,031 (266)

Platelets and Plasminogen Activation

Thrombosis and Haemostasis, 1995
Platelets serve as a site for assembly of the proteins of the plasminogen activator system. Once bound to the platelet surface, tissue-type plasminogen activator manifests enhanced catalytic activity. Plasmin, once formed, also binds to the platelets surface and, at low concentrations, renders the platelet dysfunctional by cleaving glycoprotein IIIa ...
J, Loscalzo, B, Pasche, H, Ouimet, J E, Freedman   +3 more
openaire   +2 more sources

Plasminogen activator / plasminogen activator inhibitors in ovarian physiology

Frontiers in Bioscience, 2004
The target extracellular matrix (ECM) degradation generated by plasminogen activator (PA) and regulated by plasminogen activator inhibitor (PAI) is an event that affects a wide variety of physiological and pathological processes in the ovary. Studies carried out over the past 25 years in a number of laboratories have elucidated some of the biochemical ...
openaire   +2 more sources

Plasminogen/plasminogen activator and growth factor activation.

Ciba Foundation symposium, 1997
The plasminogen/plasminogen activator system is widely used in extracellular proteolysis. In this review the involvement of this system in tumour invasion, cell migration, growth factor presentation and inhibition of angiogenesis are discussed.
Rifkin, DB, Gleizes, PE, Harpel, J, Nunes, I, Munger, J, Mazzieri, R, Noguera, I   +6 more
openaire   +4 more sources

Plasminogen activators: A comparison

Vascular Pharmacology, 2006
Thrombolytic drugs play a crucial role in the management of patients with acute myocardial infarction, pulmonary embolism, deep vein thrombosis, arterial thrombosis, acute thrombosis of retinal vessel, extensive coronary emboli, and peripheral vascular thromboembolism.
Dev B, Baruah, Rajendra N, Dash, M R, Chaudhari, S S, Kadam   +3 more
openaire   +2 more sources

Plasminogen Activators and Angiogenesis

1996
The formation of capillaries from preexisting blood vessels (angiogenesis) occurs in a variety of normal and pathological conditions, including organ development, would healing and tumor growth. Angiogenesis requires a strict temporal modulation of opposing cell functions: cell proliferation and migration, and extracellular matrix (ECM) degradation in ...
P, Mignatti, D B, Rifkin
openaire   +2 more sources

Plasminogen activation and cancer

Thrombosis and Haemostasis, 2005
SummaryBreakdown of the extracellular matrix is crucial for cancer invasion and metastasis. It is accomplished by the concerted action of several proteases, including the serine protease plasmin and a number of matrix metalloproteases. The activity of each of these proteases is regulated by an array of activators, inhibitors and cellular receptors ...
Danø, Keld, Behrendt, N., Hoyer-Hansen, G., Johnsen, Morten, Lund, L. R., Ploug, Michael, Nielsen, John Rømer   +6 more
openaire   +3 more sources

Plasminogen activator inhibitors

Trends in Cardiovascular Medicine, 1991
Plasminogen activator inhibitors (PAIs) regulate plasminogen activation in normal and pathologic processes. Plasminogen activator inhibitor 1 (PAI-1) is the major physiologic inhibitor of both tissue-type and urokinase-type plasminogen activators. It is a highly regulated single-chain glycoprotein, whose overexpression in vivo impairs the fibrinolytic ...
J, Schneiderman, D J, Loskutoff
openaire   +2 more sources

Zymographic Evaluation of Plasminogen Activators and Plasminogen Activator Inhibitors

2004
Publisher Summary The plasminogen activator/plasminogen activator inhibitor (PA/PAI) system is of considerable fundamental importance in elucidating the biochemical mechanisms of many physiological and patho-physiological processes. Although many techniques are available to assess the PA/PAI system, including ELISA and molecular assays, fibrin ...
openaire   +2 more sources

Activating effect of the plasminogen activators on plasminogens of different mammalia species

Thrombosis Research, 1995
Abstract Plasmin (E.C. 3.4.21.7.) is a major serine proteolytic enzyme responsible for fibrinolytic function in mammalia blood plasma. It is formed by activation of proenzyme plasminogen with the known activators such as urokinase (UK, E.C. 3.4.21.31.), tissue-type plasminogen activator (t-PA, E.C. 3.4.21.67.) or streptokinase (SK) (1, 2).
S A, Yakovlev, M V, Rublenko, V I, Izdepsky, E M, Makogonenko   +3 more
openaire   +2 more sources

The potentiating effect of platelet on plasminogen activation by tissue plasminogen activator

Thrombosis Research, 1985
A new role for platelets in fibrinolysis is proposed. Platelets (euglobulin from platelet rich plasma and from human platelet extract) may potentiate plasminogen activation by tissue plasminogen activator (tPA). The potentiating activity was detected by both chromogenic substrate and fibrin plate analysis. The fibrinolysis-potentiating substance in the
K, Deguchi, S, Murashima, S, Shirakawa, C, Soria, J, Soria, F, Dunn, G, Tobelem   +6 more
openaire   +2 more sources