Results 241 to 250 of about 3,479,441 (357)

Spatial Myeloid Landscape of Large Artery Atherosclerotic and Cardioembolic Thrombi Retrieved by Mechanical Thrombectomy

The FASEB Journal, Volume 39, Issue 23, 15 December 2025.
This study employed GeoMx digital spatial profiling of thrombi retrieved by mechanical thrombectomy from ischemic stroke patients. Spatial transcriptomic analysis revealed distinct immune signatures, suggesting subtype‐specific mechanisms of immunothrombosis. Neutrophil extracellular trap–related pathways were enriched in cardioembolic thrombi, whereas
Sugyeong Jo, Taedong Ok, Chae Min Lee, Jae Woong Jeong, Yun Ju Lee, Sung Jae Shin, Sungsoon Fang, Kyung‐Yul Lee, Bo Kyung Yoon   +8 more
wiley   +1 more source

Soluble Urokinase Plasminogen Activator Receptor Predicts Survival and Hepatic Decompensation in Advanced Hepatocellular Carcinoma. [PDF]

Liver Int
Artusa F, Lamatsch S, Phan MD, Özdirik B, Berger H, Egerer M, Knorr-Klocke J, Fischer J, Veelken R, van Bömmel F, Berg T, Kappert K, Tauber R, Puengel T, Engelmann C, Demir M, Tacke F, Mohr R.   +17 more
europepmc   +1 more source

A tissue-type plasminogen activator mutant with prolonged clearance in vivo. Effect of removal of the growth factor domain.

, 1988
Molly Browne, J.E. Carey, C.G. Chapman, A. W. R. TYRRELL, Claire Entwisle, G. M. Lawrence, B. Reavy, Ian B. Dodd, A.F. Esmail, J.H. Robinson   +9 more
openalex   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, Volume 19, Issue 12, Page 3685-3705, December 2025.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Tissue Plasminogen Activator to Resolve Elevated Purge System Pressure in a Catheter-Based Ventricular Assist Device. [PDF]

JACC Case Rep
Khattak S, Shamkhani W, Maqableh GM, Al-Shatanawi A, Khan SQ.   +4 more
europepmc   +1 more source

Periodicity in the levels of serum plasminogen activator inhibitor-1 is a robust prognostic factor for embryo implantation and clinical pregnancy in ongoing IVF cycles

, 2014
BinduN Mehta, Nirmalendu Nath, Natachandra Chimote   +2 more
openalex   +1 more source

Understanding Cardiovascular Events With JAK Inhibitors: Similarities and Differences of the Vascular Effects Between Different JAK Inhibitors on Endothelial Cells Exposed to Inflammatory Cytokines

ACR Open Rheumatology, Volume 7, Issue 12, December 2025.
Objective A cardiovascular safety issue has been associated with JAK inhibitors (JAKi). This study compares the effects of distinct approved JAKi on endothelial cell (EC) dysfunction and apoptosis during inflammation. Methods Massive inflammation was induced in human vascular ECs by tumor necrosis factor (TNF) with interleukin‐17A (IL‐17A) treated or ...
Aliki Zavoriti, Pierre Miossec
wiley   +1 more source

Targeting autophagy and plasminogen activator inhibitor-1 increases survival and remodels the tumor microenvironment in glioblastoma. [PDF]

J Exp Clin Cancer Res
Shifman SG, O'Connor JL, Radin DP, Sharma A, Infante L, Ferraresso F, Kastrup CJ, Lawrence DA, Tsirka SE.   +8 more
europepmc   +1 more source

Ca2+ potentiates cAMP-dependent expression of urokinase-type plasminogen activator gene through a calmodulin- and protein kinase C-independent mechanism.

, 1990
Annemarie Ziegler, Jörg Hagmann, Birgit Kiefer, Yoshikuni Nagamine   +3 more
openalex   +1 more source

Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications

Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.
This review discusses the bioconjugation of novel materials grouped under “biological”, “hybrid” and “synthetic” categories. Medical applications ranging from cancer therapy and diagnostics to optogenetics and tissue engineering are explored, and conjugation trends are highlighted as a general guide. The review concludes with a comparison of techniques
Ellie Martin, Sean P. Doidge, Eiman Aleem, Suela Kellici, Steven Dunn, Claire Atkinson, Philip D. Howes   +6 more
wiley   +1 more source