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Plasminogen activation and cancer
Thrombosis and Haemostasis, 2005SummaryBreakdown of the extracellular matrix is crucial for cancer invasion and metastasis. It is accomplished by the concerted action of several proteases, including the serine protease plasmin and a number of matrix metalloproteases. The activity of each of these proteases is regulated by an array of activators, inhibitors and cellular receptors ...
Danø, Keld +6 more
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Plasminogen activator and cancer
European Journal of Cancer and Clinical Oncology, 1984Plasminogen activator is a protease which catalyses the conversion of the inactive plasminogen to the active plasmin. Most transformed cell lines and solid tumors produce elevated levels of plasminogen activator compared with nontransformed counterparts. This increased synthesis of plasminogen activator may play a role in tumorigenesis, cancer invasion
M J, Duffy, P, O'Grady
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Urokinase-type plasminogen activator
The International Journal of Biochemistry & Cell Biology, 2007Urokinase-type plasminogen activator (uPA) is a serine protease involved in tissue remodeling and cell migration. At the gene level, the interplay between a complex enhancer, required for induced and basal transcription, and the minimal promoter finely tunes uPA expression.
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Neurology, 2007
Tissue-type plasminogen activator (tPA) is a serine protease that cleaves plasminogen into active plasmin. In plasma, the primary function of plasmin is the digestion of fibrin, and therefore, tPA is used as a thrombolytic agent for acute treatment of ischemic stroke.
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Tissue-type plasminogen activator (tPA) is a serine protease that cleaves plasminogen into active plasmin. In plasma, the primary function of plasmin is the digestion of fibrin, and therefore, tPA is used as a thrombolytic agent for acute treatment of ischemic stroke.
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Tissue-Type Plasminogen Activator
Pathophysiology of Haemostasis and Thrombosis, 1986Tissue-type plasminogen activator (t-PA) is a serine protease with a molecular weight of about 70,000. It activates plasminogen to plasmin by cleavage of the Arg 560-Val 561 peptide bond. Kinetic analysis showed that the activation obeys Michaelis-Menten kinetics and that the presence of fibrin strikingly enhances the activation rate.
H R, Lijnen, D, Collen
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Fibrin‐Mediated Plasminogen Activation
Annals of the New York Academy of Sciences, 2001Abstract: Fibrin, but not fibrinogen, enhances the rate of activation of plasminogen by tissue type plasminogen activator (t‐PA). Studies with enzymatic and chemical fragments of fibrinogen showed that several sites in fibrinogen are involved in this rate enhancement; these are, Aα148–160 (located in CNBr fragment FCB‐2), and FCB‐5 (a CNBr fragment ...
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Journal of the American Medical Association (JAMA), 1995
W. Hacke +9 more
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W. Hacke +9 more
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Plasminogen Activator Release Assays
Acta Clinica Belgica, 1977SummaryIt has been found that a certain group of individuals fail to release, or release only very small amounts of plasminogen activator on exposure to a standardized stimulus (poor responders).For measuring the fibrinolytic response or capacity, venous occlusion of the limbs is a rather simple method, without potential sideeffects, which makes it ...
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MEASURING PLASMINOGEN ACTIVATOR
The Lancet, 1977L, Uziel, S A, Cederholm-Williams
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The Role of Plasminogen Activator Inhibitor Type-1 in Fibrosis
Seminars in Thrombosis and Hemostasis, 2016P. Flevaris, Douglas E. Vaughan
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