Results 61 to 70 of about 241,486 (290)

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito, Assfalg-Machleidt, Irmgard, Magdolen, Ulla, Schmitt, Manfred, Rettenberger, Peter, Magdolen, Viktor, Krol, Janna   +6 more
core   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

PLAUR (plasminogen activator, urokinase receptor) [PDF]

, 2010
Review on PLAUR (plasminogen activator, urokinase receptor), with data on DNA, on the protein encoded, and where the gene is ...
B Jacobsen, M Ploug, M Illemann, Jacobsen, B, Ploug, M, Illemann, M   +5 more
core   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Involvement of the plasminogen activator/plasmin proteolytic cascade in fertilization

, 1993
At the time of fertilization both murine gametes express plasminogen-dependent proteolytic activity: unfertilized eggs secrete tissue-type plasminogen activator and ejaculated spermatozoa have urokinase-type plasminogen activator bound to their surface ...
Huarte, Joachim, Vassalli, Jean-Dominique, Sakkas, D., Belin, Dominique, Vassalli JD, Sakkas D, Huarte J, Belin D   +7 more
core   +1 more source

Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice [PDF]

, 2013
Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH).
Emiri Mandeville, Cianchetti, Flor A., Ken Arai, van Leyen, Klaus, Frieder Schlunk (280822), Eng H. Lo (112154), Kazim Yigitkanli, Chris B Schaffer, Mandeville, Emiri, Yigitkanli, Kazim, Xiaoying Wang, Nathanael L Rosidi, Chris B. Schaffer (155846), Arne Lauer (280824), Fan, Xiang, Eng H Lo, Helmuth Steinmetz (149409), Rosidi, Nathanael L., Xiang Fan (280830), Schlunk, Frieder, Frieder Schlunk, Flor A. Cianchetti (280825), Wang, Xiaoying, Christian Foerch (149410), Flor A Cianchetti, Kazim Yigitkanli (280829), Arai, Ken, Förch, Christian, Leyen, Klaus van, Lo, Eng H., Foerch, Christian, Xiang Fan, Schaffer, Chris B., Ken Arai (280828), Klaus van Leyen, Helmuth Steinmetz, Emiri Mandeville (280827), Steinmetz, Helmuth, Christian Foerch, Lo, Eng, Arne Lauer, Nathanael L. Rosidi (280821), Xiaoying Wang (30853), Klaus van Leyen (280831), Lauer, Arne, Lo Eng H., Steinmetz Helmuth, Fan Xiang, Yigitkanli Kazim, Schlunk Frieder, Lauer Arne, Wang Xiaoying, Mandeville Emiri, Cianchetti Flor A., Arai Ken, Schaffer Chris B., Rosidi Nathanael L., van Leyen Klaus, Foerch Christian   +58 more
core   +2 more sources

Hemocompatible Glycogen‐Tissue Plasminogen Activator Complexes for Enhanced Blood Clot Dissolution

Advanced Healthcare Materials, EarlyView.
Glycogen–heparin‐cRGD nanoparticles enable targeted delivery of tissue plasminogen activator (tPA) to thrombi through activated platelet recognition. The hemocompatible hybrids minimize interactions with blood and immune cells while retaining enzymatic biodegradability.
Nadiia Davydiuk, Vaidehi Londhe, Susanne Boye, Martin Müller, Carsten Werner, Manfred F. Maitz, Quinn A. Besford   +6 more
wiley   +1 more source

Tissue plasminogen activator for dysfunctional tunneled vascular catheters for hemodialysis - single center experience [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2019
Introduction/Objective. Thrombosis of hemodialysis catheters is one of the major complications, which leads to catheter dysfunction. Although tissue plasminogen activator has been proven to be effective in reestablishing blood flow rate through ...
Todorov Verica, Janković Aleksandar, Đurić Petar, Bulatović Ana, Popović Jovan, Dimković Nada   +5 more
doaj   +1 more source

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source