Results 71 to 80 of about 3,602,430 (295)

Coagulation and anticoagulation in idiopathic pulmonary fibrosis [PDF]

, 2015
Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive interstitial lung disease with a prognosis that is worse than that of many cancers. Epidemiological studies have demonstrated a link between IPF and thrombotic vascular events.
Crooks, Michael G., Hart, Simon P.
core   +3 more sources

Mutant and chimeric recobinant plasminogen activatorsproduction in eukaryotic cellsand preliminary characterization [PDF]

, 1987
Mutant urokinase-type plasminogen activator (u-PA) genes and hybrid genes between tissue-type plasminogen activator (t-PA) and u-PA have been designed to direct the synthesis of new plasminogen activators and to investigate the structure-function ...
Andre, B., Bollen, A., Collen, D., Cravador, A., Deforesta, F., Dewilde, M., Gheysen, D., Herzog, A., Hoylaerts, M., Jacobs, P., Pierard, L., Topisirovic, L.   +11 more
core   +1 more source

Genome-Wide Multiple Sclerosis Association Data and Coagulation [PDF]

, 2019
The emerging concept of a crosstalk between hemostasis, inflammation, and immune system prompt recent works on coagulation cascade in multiple sclerosis (MS).
Arianna Fornasiero, Giovanni Ristori, Marco Salvetti, Marco Salvetti, Maria Chiara Buscarinu, Michela Ferraldeschi, Renato Umeton, Renato Umeton, Rosella Mechelli, Sara La Starza, Silvia Romano   +10 more
core   +2 more sources

The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans.

Brain : a journal of neurology, 2012
The neurovascular unit provides a dynamic interface between the circulation and central nervous system. Disruption of neurovascular integrity occurs in numerous brain pathologies including neurotrauma and ischaemic stroke. Tissue plasminogen activator is
M. Sashindranath, E. Sales, M. Daglas, R. Freeman, A. Samson, E. Cops, S. Beckham, A. Galle, C. Mclean, C. Morganti-Kossmann, J. Rosenfeld, R. Madani, J. Vassalli, E. Su, D. Lawrence, R. Medcalf   +15 more
semanticscholar   +1 more source

Lingual Haematoma due to Tenecteplase in a Patient with Acute Myocardial Infarction

Case Reports in Otolaryngology, 2013
The use of intravenous thrombolytic agents has revolutionised the treatment of acute myocardial infarction. However, the improvement in mortality rate achieved with these drugs is tempered by the risk of serious bleeding complications, including ...
Muhlis Bal, Yavuz Atar, Ziya Salturk, Ahmet Hakan Ateş, Serkan Yağcı, Gökçen Coşkun Bal   +5 more
doaj   +1 more source

PAI-1 and t-PA/PAI-1 complex potential markers of fibrinolytic bleeding after cardiac surgery employing cardiopulmonary bypass

BMC Anesthesiology, 2012
Background Enhanced bleeding remains a serious problem after cardiac surgery, and fibrinolysis is often involved. We speculate that lower plasma concentrations of plasminogen activator inhibitor – 1 (PAI-1) preoperatively and tissue plasminogen activator/
Ozolina Agnese, Strike Eva, Jaunalksne Inta, Krumina Angelika, Bjertnaes Lars J, Vanags Indulis   +5 more
doaj   +1 more source

Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial [PDF]

, 2009
<br>Background: Metformin reduces cardiovascular risk in patients with type 2 diabetes seemingly independent of lowering blood glucose concentration. We assessed the cardiovascular effects of metformin in individuals without type 2 diabetes.</br&
Eddy, Despres, Grundy, Bird, Seifarth, Nathan, Fontbonne, Charles, Holman, Kooy, Knowler, Alberti, Vergeer, Touboul, Liang, Spence, Levey, Meaney, Taylor, Selvin, Boussageon, Sjöström, Shyangdan, de Jager, Bots, Taylor, Boden, Huang, Baigent, Lorenz, Mazzone, Taylor, Lonn, Lexis   +33 more
core   +5 more sources

Soluble urokinase plasminogen activator receptor and cardiotoxicity in doxorubicin-treated breast cancer patients: a prospective exploratory study

Cardio-Oncology
Background Soluble urokinase plasminogen activator receptor is an inflammatory biomarker that may prognosticate cardiovascular outcomes. We sought to determine the associations between soluble urokinase plasminogen activator receptor and established ...
Jian Chu, Lillian Tung, Issam Atallah, Changli Wei, Melody Cobleigh, Ruta Rao, Steven B. Feinstein, Lydia Usha, Kathrin Banach, Jochen Reiser, Tochukwu M. Okwuosa   +10 more
doaj   +1 more source

Origin and diversification of the plasminogen activation system among chordates

BMC Evolutionary Biology, 2019
Background The plasminogen (PLG) activation system is composed by a series of serine proteases, inhibitors and several binding proteins, which together control the temporal and spatial generation of the active serine protease plasmin. As this proteolytic
Andrés Chana-Muñoz, Agnieszka Jendroszek, Malene Sønnichsen, Tobias Wang, Michael Ploug, Jan K. Jensen, Peter A. Andreasen, Christian Bendixen, Frank Panitz   +8 more
doaj   +1 more source

Effects of moderate weight loss on anginal symptoms and indices of coagulation and fibrinolysis in overweight patients with angina pectoris [PDF]

, 2002
Objective: To evaluate the effects of moderate weight loss, in overweight patients with angina, on plasma coagulation, fibrinolytic indicies and pain frequency.
Hankey, C.R., Lean, M.E.J., Lowe, G.D.O., Rumley, A., Woodward, M.   +4 more
core   +1 more source