Results 81 to 90 of about 3,602,430 (295)

The plasmin-antiplasmin system: structural and functional aspects [PDF]

, 2018
The plasmin-antiplasmin system plays a key role in blood coagulation and fibrinolysis. Plasmin and α2-antiplasmin are primarily responsible for a controlled and regulated dissolution of the fibrin polymers into soluble fragments. However, besides plasmin(
Gerber, Simon, Schaller, Johann
core  

PLASMINOGEN ACTIVATOR OF YERSINIA PESTIS

Инфекция и иммунитет, 2015
Plague has been the cause of three pandemics and has led to the death of millions of people. Plague is a typical zoonosis caused by Yersinia pestis that circulates in populations of wild rodents inhabiting natural plague foci on all continents except for
V. V. Evseeva, M. E. Platonov, P. Kh. Kopylov, S. V. Dentovskaya, A. P. Anisimov   +4 more
doaj   +1 more source

Tissue plasminogen activator dose and pulmonary artery pressure reduction in catheter directed thrombolysis of submassive pulmonary embolism. [PDF]

, 2019
PURPOSE:The purpose of this study is to assess the incremental effect of tissue plasminogen activator (t-PA) dose on pulmonary artery pressure (PAP) and bleeding during catheter directed thrombolysis (CDT) of submassive pulmonary embolism (PE). MATERIALS
Gaba, Ron C, Liu, Li, Lokken, R Peter, Patel, Darshan C   +3 more
core   +2 more sources

A network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic heart failure [PDF]

, 2019
Aims Heart failure (HF) is frequently caused by an ischaemic event (e.g. myocardial infarction) but might also be caused by a primary disease of the myocardium (cardiomyopathy).
Anker, Stefan D., Cleland, John G. F., Dickstein, Kenneth, Hillege, Hans L., Lam, Carolyn S. P., Lang, Chim C., Metra, Marco, Nauta, Jan F., Ng, Leong L., Romaine, Simon P. R., Sama, Iziah E., Samani, Nilesh J., Ter Maaten, Jozine M., Tromp, Jasper, van der Meer, Peter, van Veldhuisen, Dirk J., Voors, Adriaan A., Woolley, Rebecca J., Zannad, Faiez   +18 more
core   +5 more sources

A High Affinity Interaction of Plasminogen with Fibrin Is Not Essential for Efficient Activation by Tissue-type Plasminogen Activator*

Journal of Biological Chemistry, 2011
Background: Although fibrin promotes plasminogen activation by tissue-type plasminogen activator by serving as a template, the importance of the plasminogen/fibrin interaction is unclear. Results: Fibrin promoted Lys- and Mini-plasminogen activation to a
P. Kim, L. Tieu, A. Stafford, J. Fredenburgh, J. Weitz   +4 more
semanticscholar   +1 more source

The Roles of Fibrinolytic Factors in Bone Destruction Caused by Inflammation

Cells
Chronic inflammatory diseases, such as rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, Crohn’s disease, periodontitis, and carcinoma metastasis frequently result in bone destruction.
Yosuke Kanno
doaj   +1 more source

Dose escalation of desmoteplase for acute ischemic stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onset [PDF]

, 2006
<p><b>Background and Purpose:</b> Desmoteplase is a novel plasminogen activator with favorable features in vitro compared with available agents.
Al, R.Y., Albers, G.W., Eyding, D., Furlan, A.J., Hacke, W.l, Lees, K.R., Rowley, H.A., Sachara, C., Soehngen, M., Warach, S.   +9 more
core   +1 more source

Streptolysin O accelerates the conversion of plasminogen to plasmin

Nature Communications
Group A Streptococcus (GAS) is a human-specific bacterial pathogen that can exploit the plasminogen-plasmin fibrinolysis system to dismantle blood clots and facilitate its spread and survival within the human host.
Di Tang, Hamed Khakzad, Elisabeth Hjortswang, Lars Malmström, Simon Ekström, Lotta Happonen, Johan Malmström   +6 more
doaj   +1 more source

SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer [PDF]

, 2017
Pancreatic cancer has a devastating prognosis, with an overall 5-year survival rate of ~8%, restricted treatment options and characteristic molecular heterogeneity.
A H Allam, A Neesse, A Neesse, A V Biankin, A Xue, AB Seymour, AD Rhim, AK Witkiewicz, AM LeBeau, AR Shekouh, AV Biankin, B Hinz, BC Ozdemir, BJ Cochran, BJ Cochran, C Gaggioli, C Vennin, D Croucher, D Goldstein, D Herrmann, D Herrmann, D Mahadevan, D N Saunders, D Telgenhoff, DD Von Hoff, DR Croucher, DR Croucher, E Cerami, F Al-Ejeh, G Finak, H Shiomi, HW Smith, I Garrido-Laguna, J Condeelis, J Gao, J Gore, J Lee, J Li, J P Morton, J R W Conway, JA Lee, JJ Lee, JP Morton, K Kessenbrock, K L Vine, L Harris, M C Lucas, M J Cowley, M Nobis, M Pajic, M Pinese, M Ranson, MJ Duffy, ML Nyström, N L E Harris, N Waddell, P Bailey, P Carmeliet, P Timpson, P Timpson, R Cicchi, R F Shearer, R Kalluri, R Smith, RF Shearer, RG Rowe, RL Siegel, S Nurmenniemi, S Ulisse, SC Barry, SR Hingorani, SR Hingorani, TK Stutchbury, WA Schroder, Y Takeuchi, ZS Boyd, Ö Babur   +76 more
core   +1 more source

Identification of a novel regulatory mechanism for the disease associated protein, uPAR [PDF]

, 2014
Expression quantitative trait loci (eQTLs), as determined through a series of statistical association studies collectively known as genome-wide association (GWA) studies, have provided us with a hypothesis free approach for the investigation into ...
Hall, Ian P., Portelli, Michael A., Sayers, Ian   +2 more
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