Results 11 to 20 of about 399,723 (373)

Does plasminogen activator inhibitor-1 drive lymphangiogenesis? [PDF]

PLoS ONE, 2010
The purpose of this study is to explore the function of plasminogen activator inhibitor-1 (PAI-1) during pathological lymphangiogenesis. PAI-1, the main physiological inhibitor of plasminogen activators is involved in pathological angiogenesis at least ...
Françoise Bruyère, Laurence Melen-Lamalle, Silvia Blacher, Benoît Detry, Anne Masset, Julie Lecomte, Vincent Lambert, Catherine Maillard, Gunilla Høyer-Hansen, Leif R Lund, Jean-Michel Foidart, Agnès Noël   +11 more
doaj   +6 more sources

Plasminogen Activator Inhibitor-1

JACC: Basic to Translational Science, 2022
Dimitri Arangalage, Gregory Franck, Giuseppina Caligiuri   +2 more
semanticscholar   +2 more sources

Plasminogen Activator Inhibitor 1 [PDF]

Definitions, 2020

semanticscholar   +2 more sources

Plasminogen Activator Inhibitor-1 Measurement [PDF]

Definitions, 2020

semanticscholar   +2 more sources

Elevated plasma levels of plasminogen activator inhibitor‐1 are associated with risk of future incident venous thromboembolism

Journal of Thrombosis and Haemostasis, 2022
Plasminogen activator inhibitor‐1 (PAI‐1), the main inhibitor of fibrinolysis, is frequently elevated in obesity and could potentially mediate the risk of venous thromboembolism (VTE) in obese subjects.
Tobias Frischmuth, K. Hindberg, P. Aukrust, T. Ueland, S. Braekkan, J. Hansen, V. Morelli   +6 more
semanticscholar   +1 more source

Vitamin D Deficiency is Associated With Increased Plasminogen Activator Inhibitor 1/Plasminogen Activator Inhibitor 2 Ratio in Pregnancy

Clinical and Applied Thrombosis/Hemostasis, 2023
Background Vitamin D deficiency has recently been suggested as an independent risk factor for thrombosis. Notably, vitamin D deficiency is common in pregnant populations, whom already have an increased thrombotic risk.
Matilde Kanstrup Andersen BA, Isabella Hangaard Rüdiger MD, Anna Louise Vestergaard MD, PhD, Yaseelan Palarasah MS, PhD, Pinar Bor MD, PhD, Agnete Larsen MD, PhD, Mustafa Vakur Bor MD, PhD   +6 more
doaj   +1 more source

Histone deacetylase inhibitor treatment increases coronary t-PA release in a porcine ischemia model. [PDF]

PLoS ONE, 2014
BACKGROUND: The expression of the tissue plasminogen activator gene can be affected by histone deacetylation inhibition and thus appears to be under epigenetic control.
Kristina Svennerholm, Niklas Bergh, Pia Larsson, Sverker Jern, Göran Johansson, Björn Biber, Michael Haney   +6 more
doaj   +1 more source

IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Cytokine release syndrome (CRS) is a life-threatening complication induced by hyperinflammatory responses. However, no specific immunotherapies are available for its treatment.
Sujin Kang, Toshio Tanaka, H. Inoue, C. Ono, S. Hashimoto, Y. Kioi, Hisatake Matsumoto, H. Matsuura, Tsunehiro Matsubara, Kentarou Shimizu, H. Ogura, Y. Matsuura, T. Kishimoto   +12 more
semanticscholar   +1 more source

Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients

medRxiv, 2020
Background: Patients with coronavirus disease 19 (COVID-19) are at high risk for thrombotic arterial and venous occlusions, while lung histopathology often reveals fibrin-based occlusion of small vessels in patients who succumb to the disease.
Y. Zuo, M. Warnock, Alyssa Harbaugh, S. Yalavarthi, K. Gockman, M. Zuo, J. Madison, J. Knight, Y. Kanthi, D. Lawrence   +9 more
semanticscholar   +1 more source

Polymerization of Plasminogen Activator Inhibitor-1 [PDF]

Journal of Biological Chemistry, 2001
The activity of the serine proteinase inhibitor (serpin) plasminogen activator inhibitor-1 (PAI-1) is controlled by the intramolecular incorporation of the reactive loop into beta-sheet A with the generation of an inactive latent species. Other members of the serpin superfamily can be pathologically inactivated by intermolecular linkage between the ...
A, Zhou, R, Faint, P, Charlton, T R, Dafforn, R W, Carrell, D A, Lomas   +5 more
openaire   +2 more sources