Results 121 to 130 of about 68,036 (296)

Tissue plasminogen activator and plasminogen activator inhibitor-1 in human choledochal bile

Yonsei Medical Journal, 2000
Fibrinolytic properties have been detected in animal and human gallbladder (GB) bile. Plasminogen activator inhibitor-1 (PAI-1) has been reported in greater concentration in GB stone bile and may be a nucleating factor in the pathogenesis of GB stone formation. It is unknown whether or not human choledochal bile has similar properties, which could have
S J, Lee, J S, Cho, J P, Chung, K S, Lee, J B, Chung, S I, Lee, Y M, Moon, J K, Kang, S W, Kwon, H S, Chi, J R, Choi, K S, Song   +11 more
openaire   +3 more sources

Small Airways Dysfunction and Remission in Adults With Asthma: A Longitudinal Exploratory Analysis of the AssessmenT of smalL Airways involvemeNT In aSthma (ATLANTIS) Study

Allergy, EarlyView.
We conducted a post hoc analysis of ATLANTIS, a multinational prospective study including 684 adults with asthma. Fewer small airway symptoms and lower disease activity are independently associated with asthma remission. Replicated airway transcriptomic signatures show increased IL‐4/13 signalling and reduced coagulation pathways across the ATLANTIS ...
Akshi Kumar, Rory Chan, Nazanin Zounemat‐Kermani, Eleanor Quek, Ian M. Adcock, Bianca Beghe, Christopher Brightling, Dave Singh, Janwillem Kocks, Alberto Papi, Klaus F. Rabe, Ulrica Scaffidi‐Argentina, Maarten van den Berge, Monica Kraft, Salman Siddiqui   +14 more
wiley   +1 more source

IL‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways

Allergy, EarlyView.
IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama, Jun Miyata, Takao Mochimaru, Ryuta Onozato, Yo Otsu, Hisashi Sasaki, Keeya Sunata, Shinichi Okuzumi, Katsunori Masaki, Hiroki Kabata, Keinosuke Hizuka, Yoshinori Hasegawa, Ryo Konno, Yusuke Kawashima, Makoto Arita, Shigeharu Ueki, Koichi Fukunaga   +16 more
wiley   +1 more source

Plasminogen Activator Inhibitor-1

JACC: Basic to Translational Science, 2022
Dimitri Arangalage, Gregory Franck, Giuseppina Caligiuri   +2 more
openaire   +1 more source

Association between Plasma Levels of Plasminogen Activator Inhibitor-1 and Colorectal Neoplasms

Gut and Liver, 2013
Background/AimsPlasminogen activator inhibitor-1 (PAI-1) is important for tumor growth, Invasion, and metastasis. In this study, we investigated the relationship between plasma levels of PAI-1 and colorectal adenomas.Methods : We reviewed the medical ...
doaj   +1 more source

Oxygen modulates the release of urokinase and plasminogen activator inhibitor-1 by retinal pigment epithelial cells

, 2001
The aims of this study were to examine the effect of oxygen, in the presence or absence of exogenous growth factors, on the release of plasminogen activators and plasminogen activator inhibitor-1 by cultured human retinal pigment epithelial cells ...
John Jarvis-Evans, Jonathan T. Erichsen, Erichsen, Jonathan Thor, Mike Boulton, Asud Khaliq, Jarvis-Evans, J., Khaliq, A., Boulton, Michael Edwin   +7 more
core   +1 more source

Rapid Human Skin Barrier Disruption by Sodium Dodecyl Sulfate and Associated Molecular Mechanisms

Allergy, EarlyView.
Short‐term exposure to SDS rapidly disrupts human skin barrier integrity within minutes, as detected by real‐time electrical impedance spectroscopy. SDS‐induced barrier dysfunction is driven by oxidative stress, leading to suppression of immune/barrier mediators and activation of stress, lipid remodeling, and epidermal differentiation pathways ...
Manru Li, Huseyn Babayev, Paolo D'Avino, Can Zeyneloğlu, Ceren Bicer, Duygu Yazici, Yagiz Pat, Per Svedenhag, Nicolas Gaudenzio, Cezmi A. Akdis, Yasutaka Mitamura   +10 more
wiley   +1 more source

Dysregulated repair in asthmatic paediatric airway epithelial cells: The role of plasminogen activator inhibitor-1

, 2008
Background: Asthma is associated with structural changes to airways such as extracellular matrix deposition and epithelial damage. Evidence suggests that asthmatic airway epithelial repair is abnormal and that elevated plasminogen activator inhibitor-1 ...
Kicic, Anthony, Knight, D.A., Sutanto, E.N., Stick, S.M., Stevens, P.T.   +4 more
core   +1 more source

Urokinase and type I plasminogen activator inhibitor production by normal human hepatocytes: modulation by inflammatory agents

, 1994
We examined the effects of inflammatory cytokines (interleukin-1 beta, tumor necrosis factor-alpha and transforming growth factor-beta) on the plasminogen activator system (urokinase, tissue-type plasminogen activator, type 1 plasminogen activator ...
Chesne, C., Belin, D., Guillouzo, A., Hyafil, F., Nicodeme, E., Busso, N.   +5 more
core   +2 more sources

Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?

British Journal of Pharmacology, EarlyView.
Psychedelic drugs that activate 5‐HT2A receptors have been long used for cultural, medicinal and recreational purposes. Interest in psychedelics for treating psychiatric disorders has resurged recently and is well documented; less well recognised are their anti‐inflammatory properties. Growing evidence now demonstrates that psychedelics modulate immune
Omar Qureshi, Jamie Cowley, Ashley Pegg, Alison J. Cooper, John Gordon, Catherine A. Brady, Antonio Belli, Sam Butterworth, Rachel Upthegrove, Nick Andrews, Nicholas M. Barnes   +10 more
wiley   +1 more source