Results 181 to 190 of about 60,177 (254)

Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases

British Journal of Pharmacology, Volume 183, Issue 15, Page 4111-4125, August 2026.
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden, Loes C. Oskam, Lenny van Bon, Chantal P. Rovers   +3 more
wiley   +1 more source

Perinatal Intracranial Hemorrhage as a Rare Presentation of Plasminogen Activator Inhibitor-1 (PAI-1) Deficiency: A Case Report. [PDF]

Cureus
Puri N, Joshi A, Shubham S, Ahmed SM, Joshi R, Kapoor A, Mishra D, Gupta G.   +7 more
europepmc   +1 more source

Garadacimab for the long‐term prophylaxis of hereditary angioedema

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 8, Page e1034-e1044, August 2026.
Summary Hereditary angioedema (HAE), a rare and debilitating disease characterized by recurrent and spontaneous attacks of tissue swelling, has a high unmet therapeutic need, with many patients experiencing insufficient disease control with current prophylactic treatments.
Emel Aygören‐Pürsün, Regina Treudler, Petra Staubach, Inmaculada Martinez Saguer, Thomas Linhoff, Markus Magerl   +5 more
wiley   +1 more source

The Role of the Plasminogen Activator Inhibitor 1 ( <i>PAI1</i> ) in Ovarian Cancer: Mechanisms and Therapeutic Implications. [PDF]

Glob Med Genet
Mathews SG, Krishna RBD, M L, K N, Murali S, Agarwal P, Rani E, F AM.   +7 more
europepmc   +1 more source

Investigator‐Led Research to Improve the Diagnostic Assessment of Platelet Function Disorders: Reflections on the Challenges and Rewards

International Journal of Laboratory Hematology, Volume 48, Issue 4, Page 721-731, August 2026.
ABSTRACT Introduction Investigator‐led research and quality improvement initiatives have led to important improvements in the diagnostic assessment of platelet function disorders (PFD). Methods Personal reflections were used to summarize our contributions to knowledge on PFD diagnostic assessment, pathogenesis, and bleeding risks.
Catherine P. M. Hayward
wiley   +1 more source

Plasminogen activator inhibitor-1 serum levels in frontotemporal lobar degeneration. [PDF]

J Cell Mol Med
Angelucci F, Veverova K, Katonová A, Vyhnalek M, Hort J.   +4 more
europepmc   +1 more source

Mechanisms and Research Progress of Leech in Diabetic Ulcer Fibrosis

International Wound Journal, Volume 23, Issue 8, August 2026.
ABSTRACT Delayed wound healing is a major complication of diabetes, with its core pathological process being pathological fibrosis driven by persistent inflammation, metabolic disorders and vascular dysfunction under hyperglycemia. This process involves pathological retention of inflammatory cells, abnormal expression of pro‐fibrotic factors, and ...
Yanchun Wang, Xianglong Zheng, Huafa Que, Zhangren Yan   +3 more
wiley   +1 more source

Genetic Associations of Plasminogen Activator Inhibitor-1-Related miRNA Variants with Coronary Artery Disease. [PDF]

Int J Mol Sci
Ha YH, Sung JH, Ryu CS, Ko EJ, Park HW, Park HS, Kim OJ, Kim IJ, Kim NK.   +8 more
europepmc   +1 more source

Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases

Obesity Reviews, Volume 27, Issue 8, August 2026.
ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar, Joanna Razafiarison, Fawaz Alzaid, Fahd Al‐Mulla, Rasheed Ahmad   +4 more
wiley   +1 more source

Plasminogen activator inhibitor-1 mediates cerebral ischemia-induced astrocytic reactivity. [PDF]

J Cereb Blood Flow Metab
Yanev P, Martin-Jimenez C, Vesga-Jimenez DJ, Zvinys L, Weinrich N, Cree MA, Preuss TM, Zhang X, Yepes M.   +8 more
europepmc   +1 more source