Lipoprotein(a), Endothelial Dysfunction and Cardiovascular Disease
Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.ABSTRACT Lipoprotein(a) (Lp(a)) is a particle similar to low‐density lipoprotein cholesterol and is associated with apolipoprotein (A). High Lp(a) levels are a genetic, independent risk factor for atherosclerotic cardiovascular disease (ASCVD). Endothelial cells, which form the continuous lining of the cardiovascular system, are crucial for vascular ...
Xianghui Zhou +5 more
wiley +1 more source
Plasma Plasminogen Activator Inhibitor-1 as a Biomarker for Disease Activity and Pharmaco-Response Prediction in Pediatric Epilepsy: A Prospective Cohort Study. [PDF]
Neuropsychiatr Dis TreatXiao X +7 more
europepmc +1 more source
Rhenium‐Based β‐Galactosidase Probe Allows Senescence Profiling by Mass Cytometry
Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.Senescence‐associated β‐galactosidase (SA‐β‐Gal) activity is a widely accepted biomarker of cellular senescence, yet its integration with other senescence markers has been limited by available detection methods. Here, we introduce ReGal, a mass cytometry‐compatible SA‐β‐Gal activity probe that can be multiplexed with established markers of senescence ...
Adam Tam +4 more
wiley +2 more sources
Plasminogen Activator Inhibitor-1 in Skin Malignancies: Therapeutic Implications of Its Inhibition. [PDF]
BiomoleculesFujimura T, Muto Y, Asano Y.
europepmc +1 more source
Journal of Internal Medicine, Volume 300, Issue 5, Page 590-609, November 2026.Abstract Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%–13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026 reflects a fundamental shift in understanding the condition as a lifelong endocrine ...
Maria Forslund +5 more
wiley +1 more source
Plasminogen activator Inhibitor-1 in systemic sclerosis: A nexus of fibrosis, vasculopathy, and senescence. [PDF]
Biomed JTakahashi T, Takahashi T, Asano Y.
europepmc +1 more source
From Dysbiosis to Disease: How Vaginal Microbiota Shape Group B Streptococcus Pathogenesis
ChemBioChem, Volume 27, Issue 20, 28 October 2026.Lactobacillus crispatus plays a critical role in the vaginal microbiome. Limiting glucose shifts metabolism toward HMO consumption and amino acid metabolism. These actions enable alkali production and competition. Homeostasis, characterized by dense Lactobacilli colonization and suppression of pathogens, provides resistance to dysbiosis.
Julie A. Talbert, Steven D. Townsend
wiley +1 more source
4G/5G polymorphism and plasma levels of plasminogen activator inhibitor-1 in essential thrombocythemia patients with driver mutational status. [PDF]
Thromb JZhang X, Guo X.
europepmc +1 more source
Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley +1 more source
Roles of plasminogen activator inhibitor-1 in aging-related muscle and bone loss in mice. [PDF]
Aging (Albany NY)Ohira T +7 more
europepmc +1 more source