Results 221 to 230 of about 9,806 (254)

Plasminogen activator inhibitor‐1 and diabetic nephropathy

Nephrology, 2005
SUMMARY:  Diabetic nephropathy is characterized by excessive accumulation of extracellular matrix (ECM) in the kidney. Decreased ECM degradation as well as increased ECM synthesis plays an important role in ECM remodeling that favours tissue fibrosis. Plasminogen activator (PA)/plasmin/PA inhibitor (PAI) system is involved in ECM degradation and PAI‐1 ...
Hi Bahl, Lee, Hunjoo, Ha
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Plasminogen Activator Inhibitor-1 Is the Primary Inhibitor of Tissue-Type Plasminogen Activator in Pregnancy Plasma

Thrombosis and Haemostasis, 1987
SummaryThe aim of the present work was to clarify to what extent plasminogen activator inhibitor-1 (PAI-1) and plasminogen activator inhibitor-2 (PAI-2) contribute to the increase in plasma inhibition of tissue-type plasminogen activator (t-PA) observed during pregnancy.
M, Jørgensen, M, Philips, S, Thorsen, J, Selmer, J, Zeuthen   +4 more
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A model of the active form of plasminogen-activator-inhibitor-1

Fibrinolysis, 1994
A model of the reactive form of plasminogen activator inhibitor-1 (PAI-1) has been constructed using molecular graphics and starting from the known crystal structure of latent PAI-1. The residues P16 to P10', of which P16-P4 form strand 4 of the beta-sheet A (s4A) and P3-P10' form an extended loop in the latent form, have been removed and remodeled ...
K, Aertgeerts, H L, De Bondt, C, De Ranter, P J, Declerck   +3 more
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Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1

Bioorganic & Medicinal Chemistry Letters, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Ariamala, Gopalsamy, Scott L, Kincaid, John W, Ellingboe, Thomas M, Groeling, Thomas M, Antrilli, Girija, Krishnamurthy, Ann, Aulabaugh, Gregory S, Friedrichs, David L, Crandall   +8 more
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Stability of Plasminogen Activator Inhibitor 1 (PAI-1)

Thrombosis and Haemostasis, 1989
SummaryThe stability of PAI-activity has been studied at different conditions. The inactivation followed first order kinetics. Lowering the temperature and decreasing the pH both, increased the stability of PAI-1 dramatically. Addition of the PAI-1 binding protein, vitronectin, to reactivated PAI-1, about doubled the halflife of PAI-1 at all conditions
T L, Lindahl, O, Sigurdardottir, B, Wiman   +2 more
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Genetic Architecture of Tissue-Type Plasminogen Activator and Plasminogen Activator Inhibitor-1

Seminars in Thrombosis and Hemostasis, 2008
Important biochemical constituents of the fibrinolytic system include tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1). In the current review, we aim to describe the genetic architecture of t-PA and PAI-1. Several genetic polymorphisms in the T-PA and PAI-1 gene have been found to be associated with t-PA and PAI-1 ...
Asselbergs, Folkert W., Pattin, Kristine, Snieder, Harold, Hillege, Hans L., van Gilst, Wiek H., Moore, Jason H.   +5 more
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Relation of plasminogen activator inhibitor-1 activity and plasminogen activator inhibitor-1 concentration in different plasma samples

Fibrinolysis, 1994
Abstract The relationship between PAI activity, active PAI-1 concentration and whole PAI-1 concentration was determined in 180 plasma samples of unselected ambulant patients of the department of internal medicine. To exclude a release of platelet PAI-1 after blood sampling, different anticoagulants and temperatures of blood storage were tested.
G. Siegert, Th. Fritz, E. Runge
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Plasminogen activator inhibitor 1 in thrombotic disease

Current Opinion in Hematology, 1996
Impaired fibrinolytic function, mainly due to an elevation of plasma plasminogen activator inhibitor 1 concentration, is a common finding in patients with thrombotic disease. In patients subjected to hip surgery, preoperatively increased levels of plasminogen activator inhibitor 1 seem to be predictive of postoperative deep venous thrombosis.
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Determinants of Plasminogen Activator Inhibitor 1 Activity in Treated NIDDM and Its Relation to a Polymorphism in the Plasminogen Activator Inhibitor 1 Gene

Diabetes, 1995
Plasminogen activator inhibitor 1 (PAI-1) activity is increased in patients with non-insulin-dependent diabetes mellitus (NIDDM) and may contribute to their excess risk of cardiovascular disease. We examined the determinants of PAI-1 activity in 146 NIDDM subjects by using specific assays of insulin and intact and des-31,32-proinsulin and measures of ...
A, Panahloo, V, Mohamed-Ali, A, Lane, F, Green, S E, Humphries, J S, Yudkin   +5 more
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Solvent Effects on Activity and Conformation of Plasminogen Activator Inhibitor-1

Thrombosis and Haemostasis, 1999
SummaryWe have studied effects of the solvent composition on the activity and the conformation of human plasminogen activator inhibitor-1 (PAI-1) from HT-1080 fibrosarcoma cells. Non-ionic detergents, including Triton X-100, reduced the inhibitory activity of PAI-1 more than 20-fold at 0° C, but less than 2-fold at 37° C, while glycerol partly ...
Andreasen, Peter, Egelund, R., Jensen, S., Rodenburg, K.W.   +3 more
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