Results 241 to 250 of about 113,706,673 (279)
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Plasminogen Activator Inhibitor-1 in Vascular Thrombosis
Current Drug Targets, 2007Thrombotic complications of vascular disease constitute the leading cause of morbidity and mortality in much of the developed world. Current drug therapies available to treat the thrombotic component of arterial and venous vascular complications remain limited.
Randal J, Westrick, Daniel T, Eitzman
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Plasminogen activator inhibitor 1 in thrombotic disease
Current Opinion in Hematology, 1996Impaired fibrinolytic function, mainly due to an elevation of plasma plasminogen activator inhibitor 1 concentration, is a common finding in patients with thrombotic disease. In patients subjected to hip surgery, preoperatively increased levels of plasminogen activator inhibitor 1 seem to be predictive of postoperative deep venous thrombosis.
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Thrombosis and Haemostasis, 1987
SummaryThe aim of the present work was to clarify to what extent plasminogen activator inhibitor-1 (PAI-1) and plasminogen activator inhibitor-2 (PAI-2) contribute to the increase in plasma inhibition of tissue-type plasminogen activator (t-PA) observed during pregnancy.
M, Jørgensen +4 more
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SummaryThe aim of the present work was to clarify to what extent plasminogen activator inhibitor-1 (PAI-1) and plasminogen activator inhibitor-2 (PAI-2) contribute to the increase in plasma inhibition of tissue-type plasminogen activator (t-PA) observed during pregnancy.
M, Jørgensen +4 more
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A model of the active form of plasminogen-activator-inhibitor-1
Fibrinolysis, 1994A model of the reactive form of plasminogen activator inhibitor-1 (PAI-1) has been constructed using molecular graphics and starting from the known crystal structure of latent PAI-1. The residues P16 to P10', of which P16-P4 form strand 4 of the beta-sheet A (s4A) and P3-P10' form an extended loop in the latent form, have been removed and remodeled ...
K, Aertgeerts +3 more
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Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1
Bioorganic & Medicinal Chemistry Letters, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Ariamala, Gopalsamy +8 more
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Plasminogen Activator Inhibitor 1 and Atherothrombosis
Thrombosis and Haemostasis, 1993I, Juhan-Vague, M C, Alessi
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