Results 51 to 60 of about 58,767 (165)

Review: Therapeutic potential of plasminogen activator inhibitor-1 inhibitors

Therapeutic Advances in Cardiovascular Disease, 2010
Plasminogen activator inhibitor-1 (PAI-1) is the major physiological inhibitor of fibrinolysis and regulates cell migration and fibrosis. Preclinical studies using genetically altered mice and biological or small molecule inhibitors have elucidated a role for PAI-1 in the pathogenesis of thrombosis, vascular remodeling, renal injury, and initiation of
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Plasminogen Activator Inhibitor-1 Levels and Polymorphisms

Archives of Pathology & Laboratory Medicine, 2002
Abstract Objective.—To review the published evidence of a relationship between levels of plasminogen activator inhibitor-1 (PAI-1) or the 4G/5G polymorphism of the PAI-1 gene and the occurrence of venous thromboembolic disease. Methods.—Review of the medical literature using computerized databases and a review of secondary
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Tissue plasminogen activator and plasminogen activator inhibitor-1 in human choledochal bile

Yonsei Medical Journal, 2000
Fibrinolytic properties have been detected in animal and human gallbladder (GB) bile. Plasminogen activator inhibitor-1 (PAI-1) has been reported in greater concentration in GB stone bile and may be a nucleating factor in the pathogenesis of GB stone formation. It is unknown whether or not human choledochal bile has similar properties, which could have
S J, Lee, J S, Cho, J P, Chung, K S, Lee, J B, Chung, S I, Lee, Y M, Moon, J K, Kang, S W, Kwon, H S, Chi, J R, Choi, K S, Song   +11 more
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Human breast cancer cell-mediated bone collagen degradation requires plasminogen activation and matrix metalloproteinase activity

Cancer Cell International, 2005
Background Breast cancer cells frequently metastasize to the skeleton and induce extensive bone destruction. Cancer cells produce proteinases, including matrix metalloproteinases (MMPs) and the plasminogen activator system (PAS) which promote invasion of
Hill Peter A, Morgan Hayley
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Retraction: The effects of residual platelets in plasma on plasminogen activator inhibitor-1 and plasminogen activator inhibitor-1-related assays. [PDF]

PLoS ONE, 2018
PLOS ONE Editors
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Metabolic syndrome, plasminogen activator inhibitor (pai-1) and atherosclerosis

Zdravniški Vestnik, 2005
Background: Metabolic syndrome is associated with high cardiovascular morbidity and mortality and its increasing prevalence is becoming one of the major health problems.
Alenka Mavri
doaj  

Effect of Plasma Soluble Urokinase-Type Plasminogen Activator Receptor and Plasminogen Activator Inhibitor-1 Levels in the Plasma of Babylon Women with Breast Cancer

Medical Journal of Babylon
Background: Worldwide, the occurrence of breast cancer is elevated as well as the number of mortality in women cancers. The movement of cancer cells from the first stage and invasion of the surrounding tissue are called cancer metastasis.
Sheerin H. Abbas, Zinah Abbass Ali, Alaa Sadiq Alaawad   +2 more
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The Roles of Fibrinolytic Factors in Bone Destruction Caused by Inflammation

Cells
Chronic inflammatory diseases, such as rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, Crohn’s disease, periodontitis, and carcinoma metastasis frequently result in bone destruction.
Yosuke Kanno
doaj   +1 more source

Angiogenesis outcomes of metformin utilization in diabetes mellitus: a systematic review and meta-analysis

Journal of the Pakistan Medical Association
Objective: To review relevant literature regarding the role of metformin in angiogenesis among diabetic patients. Method: The systematic review and meta-analysis conducted from May to September 2022, and comprised search on Medline, ScienceDirect ...
Primasitha Maharani Harsoyo, Hanestya Oky Hermawan, Arisvia Sukma Hariftyani, Farah Aisha Shabrina, Anisya Dinda Paramitha, Saskia Ratna Desita, Yudi Her Oktaviono   +6 more
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Causal association of plasminogen activators and their inhibitors with Alzheimer’s disease: a Mendelian randomization study

Archives of Medical Science
Introduction Alzheimer’s disease (AD) is the most common cause of dementia and contributes to a huge burden of disease worldwide. Observational studies have found that tissue plasminogen activator (t-PA) inhibits the development of AD, but little is ...
Xin Guo, Fangyu Gao, Baolong Pan, Feng Gao, Jingsi Zhang, Shanshan Wang, Qiao Niu   +6 more
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