Results 61 to 70 of about 68,036 (296)

Platelets retain high levels of active plasminogen activator inhibitor 1. [PDF]

PLoS ONE, 2011
The vascular fibrinolytic system is crucial for spontaneous lysis of blood clots. Plasminogen activator inhibitor 1 (PAI-1), the principal inhibitor of the key fibrinolytic enzyme tissue-type plasminogen activator (tPA), is present in platelets at high ...
Helén Brogren, Karin Wallmark, Johanna Deinum, Lena Karlsson, Sverker Jern   +4 more
doaj   +1 more source

A Serpin With a Finger in Many PAIs: PAI-1's Central Function in Thromboinflammation and Cardiovascular Disease

Frontiers in Cardiovascular Medicine, 2021
Plasminogen activator inhibitor 1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily. PAI-1 is the principal inhibitor of the plasminogen activators, tissue plasminogen activator (tPA), and urokinase-type plasminogen activator (uPA)
Gael B. Morrow, Gael B. Morrow, Claire S. Whyte, Nicola J. Mutch   +3 more
doaj   +1 more source

The effects of a plant proteinase inhibitor from Enterolobium contortisiliquum on human tumor cell lines [PDF]

, 2011
Supplementary to the efficient inhibition of trypsin, chymotrypsin, plasma kallikrein, and plasmin already described by the EcTI inhibitor from Enterolobium contortisiliquum, it also blocks human neutrophil elastase (K(iapp)=4.3 nM) and prevents phorbol ...
Sampaio, Misako U. [UNIFESP], Oliva, Maria Luiza V. [UNIFESP], Maria Luiza V. Oliva, Mayer, Barbara, Neth, Peter, Andrade de Paula, Claudia Alessandra [UNIFESP], Sampaio, Misako U., Nakahata, Adriana Miti [UNIFESP], Christian Ries, Adriana Miti Nakahata, Andrade de Paula, Claudia Alessandra, Karow, Marisa, Barbara Mayer, Cláudia Alessandra Andrade de Paula, Marisa Karow, Marianne Jochum, Oliva, Maria Luiza V., Jochum, Marianne, Misako U. Sampaio, Ries, Christian, Nakahata, Adriana Miti, Peter Neth   +21 more
core   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation

Scientific Reports, 2017
Plasminogen activator inhibitor-1 (PAI-1) is known to protect mice against cardiac fibrosis. It has been speculated that PAI-1 may regulate cardiac fibrosis by inactivating urokinase-type plasminogen activator (uPA) and ultimately plasmin (Pm) generation.
Kamlesh K. Gupta, Deborah L. Donahue, Mayra J. Sandoval-Cooper, Francis J. Castellino, Victoria A. Ploplis   +4 more
doaj   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Elevation of serum plasminogen activator inhibitor-1 predicts postoperative delirium independent of neural damage: a sequential analysis

Scientific Reports, 2022
Older adult surgical patients are susceptible to developing delirium. Early intervention can be initiated if a potential biomarker associated with delirium can be identified during the acute phase of surgery. Therefore, we investigated the changes in the
Kazuhito Mietani, Maiko Hasegawa-Moriyama, Koichi Yagi, Reo Inoue, Toru Ogata, Nobutake Shimojo, Yasuyuki Seto, Kanji Uchida, Masahiko Sumitani   +8 more
doaj   +1 more source

Association of Celiac Disease and Plasminogen Activator Inhibitor-1 Polymorphism

Genel Tıp Dergisi, 2022
Objective: Celiac disease (CD) is an autoimmune disease. Although susceptibility to thrombosis in celiac patients has been reported in case studies, the cause is not yet known. PAI-1 inhibits fibrinolysis.
Nur Ramoğlu, Zuhal Çalışkan, Minenur Kalyoncu, Deniz Ağırbaşlı   +3 more
doaj   +1 more source

Time of admission to PICU in relation to plasminogen-activator-inhibitor-1 levels and outcome.

, 2016
(A) Patients admitted between 6:00 am and 12:00 am had higher plasminogen-activator-inhibitor-1 levels than patients admitted at night (P = 0.019) or in the afternoon (P = 0.007). (PAI-1 level on y-axis in logarithmic scale.
Marjon H. Cnossen (3366872), Gertjan J. Driessen (3366869), Marieke Emonts (435406), Navin P. Boeddha (3366875), Jan A. Hazelzet (435408)   +4 more
core   +1 more source