Results 81 to 90 of about 68,036 (296)

Assessment of plasminogen activator inhibitor-1 in obese Egyptian children

Egyptian Pediatric Association Gazette, 2020
Background Plasminogen activator inhibitor-1 (PAI-1) is mainly produced in the liver and in the adipose tissue. Normal fibrin clearance mechanisms were found to be affected by high plasma PAI-1 levels and thus increases risk of thrombosis. The aim of the
Marwa Farouk Mira, Ghada Mohammad Anwar, Azza Mohamed Sarry EL-Din, Safinaz Mohammed Megahed   +3 more
doaj   +1 more source

Mechanistic investigation of Liujing Toutong tablet in the treatment of cerebral ischemia–reperfusion injury in rats by the integration of serum pharmacochemistry and metabolomics

Animal Models and Experimental Medicine, EarlyView.
The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu, Ke Pei, Xiulin Wang, Wenling Li, Hongchang Li, Wangyang Xie, Xianglong Meng, Tingting Zhao, Yan Ning, Haixin Liu, Wenbin He   +10 more
wiley   +1 more source

Impaired Fibrinolysis in Pregnancy Failure

Journal of Aziz Fatimah Medical and Dental College
Objective: To explore the association between plasma plasminogen activator inhibitor 1 (PAI-1) levels and women experiencing recurrent miscarriages with no live births to those who have had one or more live births.
Samina Mohyuddin, Rabab Zehra , Samar Ekram , Zareen Naz, Shahida Kashif, Badar Jahan   +5 more
doaj   +3 more sources

Prognostic significance of uPA/PAI-1 level, HER2 status, and traditional histologic factors for survival in node-negative breast cancer patients

Radiology and Oncology, 2016
The association of HER2 status with urokinase plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1) levels raises the question whether uPA/PAI-1 level carries additional clinically relevant prognostic information independently from ...
Dovnik Nina Fokter, Takac Iztok
doaj   +1 more source

Data in support of a central role of plasminogen activator inhibitor-2 polymorphism in recurrent cardiovascular disease risk in the setting of high HDL cholesterol and C-reactive protein using Bayesian network modeling

Data in Brief, 2016
Data is presented that was utilized as the basis for Bayesian network modeling of influence pathways focusing on the central role of a polymorphism of plasminogen activator inhibitor-2 (PAI-2) on recurrent cardiovascular disease risk in patients with ...
James P. Corsetti, Peter Salzman, Dan Ryan, Arthur J. Moss, Wojciech Zareba, Charles E. Sparks   +5 more
doaj   +1 more source

Effect of lipopolysaccharide from periodontal pathogens on the production of tissue plasminogen activator and plasminogen activator inhibitor 2 by human gingival fibroblasts

, 2001
The definitive version is available at www.blackwell-synergy.comBoth tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 2 (PAI-2) are important proteolysis factors present in inflamed human periodontal tissues. The aim of the present
Xiao, Y., Bunn, Clive L, Bartold, P., Xiao, Yin, Bartold, P.Mark, Bunn, C.   +5 more
core   +1 more source

Prognostic relevance of MMP-2 (72-kD collagenase IV) in gastric cancer [PDF]

, 1998
The association of MMP-2 (matrix metalloproteinase 2, 72-kD collagenase IV) with invasive and metastatic capacity of tumor cells has implicated a potential role in the prognosis for cancer patients.
Beyer, Bianca C. M., Schildberg, Friedrich Wilhelm, Allgayer, Heike, Tarabichi, Anwar, Babic, Rudolf, Grützner, Klaus-Uwe, Heiss, Markus Maria   +6 more
core   +1 more source

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

Corrigendum: Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 complex as a serum biomarker for COVID-19 [PDF]

Frontiers in Immunology
Tetiana Yatsenko, Tetiana Yatsenko, Ricardo Rios, Tatiane Nogueira, Yousef Salama, Satoshi Takahashi, Yoko Tabe, Toshio Naito, Kazuhisa Takahashi, Kazuhisa Takahashi, Koichi Hattori, Koichi Hattori, Beate Heissig   +12 more
doaj   +2 more sources

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source