Results 131 to 140 of about 75,068 (195)

Acute Ischaemic Stroke: Therapeutic Targets and Key Modulators of the Fibrinolytic System and Clot Formation. [PDF]

Transl Stroke Res
Swarup O, Balabanski AH, Cloud GC, Medcalf RL.   +3 more
europepmc   +1 more source

Phytochemical Screening, Pharmacological Evaluation, and Exploratory In Silico Analysis of Emilia sonchifolia Extract and Solvent Fractions

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Emilia sonchifolia (L.) DC. is a medicinal plant used traditionally for the management of several disorders; however, integrated experimental evaluation of its pharmacological properties remains limited. This study evaluated the phytochemical composition and selected biological activities of the methanolic whole‐plant extract of E. sonchifolia
Md. Masud Morshed, Mohammad Arman, Mohammad Nazmul Islam, Ziaul Karim, Rakibur Rahman, Mohammed Hassan Kawsar, Md. Sohel Rana   +6 more
wiley   +1 more source

Novel Roles of Urokinase- and Tissue-Type Plasminogen Activators in Substance Use Disorders: A Narrative Review of Molecular Mechanisms and Translational Perspectives. [PDF]

Int J Mol Sci
Bahi A, Steele S.
europepmc   +1 more source

Elevated Lipoprotein(a) Predicts Recurrent Myocardial Infarction in Diabetic Patients Following Acute Coronary Syndromes

Clinical Cardiology, Volume 49, Issue 11, November 2026.
Elevated lipoprotein(a) levels are associated with an increased risk of recurrent myocardial infarction in diabetic patients following acute coronary syndromes or PCI, but not with repeat revascularization. These findings highlight Lp(a) as a key contributor to residual cardiovascular risk and a potential tool for post‐ACS risk stratification. ABSTRACT
Ermilo Echeverria‐Ortegon, Mario César Torres‐Chávez, Alfredo Pérez‐Tagle Tejeda, Paulina Caballero‐Osorno, Juan Pastor‐Cervantes, Hugo Laviada‐Molina   +5 more
wiley   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, Volume 58, Issue 6, Page 1552-1569, November 2026.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

Revisiting Inherited Metabolic Diseases (IMDs) Through the Lens of Selective Autophagy

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Selective autophagy is increasingly recognized as a fundamental quality‐control mechanism that complements bulk autophagy by enabling the targeted degradation of specific intracellular cargos, including mitochondria, endoplasmic reticulum (ER), lipid droplets, glycogen, peroxisomes, ferritin, ribosomes, and protein aggregates.
Marianna Maddaluno, Laura Cinque, Viviana Cetrangolo, Chiara De Leonibus   +3 more
wiley   +1 more source

Leptin Neutralization Attenuates Inflammaging in Endothelial and Immune Cell Models

MedComm, Volume 7, Issue 11, November 2026.
Multiple mechanisms including senescent cell accumulation, metabolic and endotoxin‐driven stimulation of immune and endothelial cells contribute to inflammaging, the chronic low‐grade inflammatory status underlying age‐related diseases. Blocking leptin signaling in experimental models of inflammaging blunts inflammation in a model‐specific manner while
Valeria Pellegrini, Rosalba La Grotta, Alessia Metallo, Francesca Carreras, Chiara Frigé, Giulia Matacchione, Angelica Giuliani, Jacopo Sabbatinelli, Fabiola Olivieri, Francesca Rispoli, Lorenzo Drago, Cesare Celeste Berra, Raffaele Marfella, Giuseppe Paolisso, Giuseppe Matarese, Claudio Procaccini, Ilaria Spatocco, Giorgia Mele, Paola de Candia, Antonio Ceriello, Francesco Prattichizzo   +20 more
wiley   +1 more source

A grading system of dynamic fibrinolysis resistance in sepsis associates with ICU outcomes. [PDF]

Am J Respir Crit Care Med
Coupland LA, Frost SA, Lin J, Pham N, Self M, Crispin PJ, Rabbolini DJ, Keragala CB, Medcalf RL, Aneman A.   +9 more
europepmc   +1 more source

A covalent peptide engager approach to equip immunotherapeutic monoclonal and pan IgG serum antibodies with new tumour‐targeting function

British Journal of Pharmacology, Volume 183, Issue 22, Page 6685-6703, November 2026.
Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier, Sandra Szu‐Wei Hwang, Anthony F. Rullo   +2 more
wiley   +1 more source

Rhenium‐Based β‐Galactosidase Probe Allows Senescence Profiling by Mass Cytometry

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Senescence‐associated β‐galactosidase (SA‐β‐Gal) activity is a widely accepted biomarker of cellular senescence, yet its integration with other senescence markers has been limited by available detection methods. Here, we introduce ReGal, a mass cytometry‐compatible SA‐β‐Gal activity probe that can be multiplexed with established markers of senescence ...
Adam Tam, Kris Elbein, Aleida G. Gonzalez, Edgar A. Arriaga, Mark Nitz   +4 more
wiley   +2 more sources