The Fibrinolytic System: Mysteries and Opportunities [PDF]
HemaSphere, 2021 The deposition and removal of fibrin has been the primary role of coagulation and fibrinolysis, respectively. There is also little doubt that these 2 enzyme cascades influence each other given they share the same serine protease family ancestry and ...
Robert L. Medcalf +1 more
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CHI3L1 on fibrinolytic system imbalance in chronic rhinosinusitis with nasal polyp [PDF]
Frontiers in ImmunologyBackgroundChronic rhinosinusitis (CRS) is an inflammatory disease affecting more than 10% of the global adult population. It is classified into Th1, Th2, and Th17 endotypes and eosinophilic and non-eosinophilic types.
Hyun-Woo Yang +9 more
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Therapeutics targeting the fibrinolytic system [PDF]
Experimental and Molecular Medicine, 2020 Fibirinolytic system: an old system as new therapeutic targets The fibrinolytic system was originally identified to dissolve blood clots, and is shown to have important roles in other pathological processes, including cancer progression, inflammation ...
Haili Lin +5 more
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All tangled up: interactions of the fibrinolytic and innate immune systems [PDF]
Frontiers in Medicine, 2023 The hemostatic and innate immune system are intertwined processes. Inflammation within the vasculature promotes thrombus development, whilst fibrin forms part of the innate immune response to trap invading pathogens.
Claire S. Whyte
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Binding and cleavage of pro-urokinase by a tegument extract of Fasciola hepatica newly excysted juveniles activate the host fibrinolytic system [PDF]
Veterinary ResearchPlasmin, the final product of fibrinolysis, is a broad-spectrum serine protease that degrades extracellular matrix (ECM) components, a function exploited by multiple pathogens for dissemination purposes.
Judit Serrat +4 more
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Berberine Targets PKM2 to Activate the t-PA-Induced Fibrinolytic System and Improves Thrombosis [PDF]
PharmaceuticalsBackground: Arterial thrombosis, a condition in which thrombi form in arteries, can lead to various acute cardiovascular diseases and impact the quality of life and survival of patients.
Zeqi Sun +11 more
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Fibrinolytic system activation immediately following trauma was quickly and intensely suppressed in a rat model of severe blunt trauma [PDF]
Scientific Reports, 2021 In severe trauma, excessive fibrinolytic activation is associated with an increase in the transfusion volume and mortality rate. However, in the first several hours after a blunt trauma, changes in fibrinolytic activation, suppression, and activation ...
Mineji Hayakawa +9 more
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Altered fibrinolytic system in rat models of depression and patients with first-episode depression [PDF]
Neurobiology of Stress, 2019 Tissue plasminogen activator (tPA) is a serine protease involved in cleavage of neurotrophic factors. In addition, tPA and neuroserpin can also directly bind to low density lipoprotein receptor-related protein 1 (LRP1), promoting neurogenesis and neurite
Wenxiu Han +9 more
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Plant-Derived Compounds and Extracts as Modulators of Plasmin Activity—A Review
Molecules, 2023 Functionality of the fibrinolytic system is based on activity of its central enzyme, plasmin, responsible for the removal of fibrin clots. Besides the hemostasis, fibrinolytic proteins are also involved in many other physiological and pathological ...
Joanna Kolodziejczyk-Czepas, Jan Czepas
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Role of plasminogen activator inhibitor-1 (PAI-1) in cancer stem cells [PDF]
World Cancer Research Journal, 2022 Objective: Plasminogen Activator Inhibitor-1 has an important role in the progression of cancer. Although there are many studies about the relation of Plasminogen Activator Inhibitor-1 (PAI-1) with cancer, there exists only a few about showing the ...
M. Irmak-Yazicioglu, K. Ergun
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