Results 31 to 40 of about 18,150,697 (227)

The fibrinolytic enzyme system in hypertension [PDF]

Journal of Clinical Pathology, 1973
Fibrinogen, fibrinogen-related antigen (FR-antigen), and components of the fibrinolytic enzyme system were measured in patients with essential hypertension, renal disease with and without hypertension, and normal subjects. Essential hypertension was associated with a decrease in plasminogen activator and an increase in FR-antigen ...
B, Bennett, D, Ogston, G P, Crawford, A S, Douglas   +3 more
openaire   +2 more sources

Clinical significance of measuring plasminogen activator inhibitor-1 in sepsis

Journal of Intensive Care, 2017
Background Disseminated thrombotic process in the microcirculation is considered to be an important cause of multiple organ dysfunction in sepsis.
Toshiaki Iba, Jecko Thachil
doaj   +1 more source

A Novel Marine Pyran-Isoindolone Compound Enhances Fibrin Lysis Mediated by Single-Chain Urokinase-Type Plasminogen Activator

Marine Drugs, 2022
Fungi fibrinolytic compound 1 (FGFC1) is a rare pyran-isoindolone derivative with fibrinolytic activity. The aim of this study was to further determine the effect of FGFC1 on fibrin clots lysis in vitro.
Chunli Gao, Simin Tang, Haixing Zhang, Huishu Zhang, Tian Zhang, Bin Bao, Yuping Zhu, Wenhui Wu   +7 more
doaj   +1 more source

The Fibrinolytic System and Thrombotic Tendency [PDF]

Pathophysiology of Haemostasis and Thrombosis, 2003
The deposition of the insoluble protein matrix, fibrin is temporary. The mainly known mechanism of proteolytic removal is orchestrated by a cascade type of proteolytic process involving ultimately the formation from plasminogen of the active degradation enzyme plasmin.
openaire   +4 more sources

Peculiarities of changes in the coagulation and fibrinolytic activity in patients with coronary heart disease and concomitant type 2 diabetes mellitus, depending on the presence of diabetic vascular complications

Mìžnarodnij Endokrinologìčnij Žurnal, 2018
Background. The purpose of this work was to study endogenous coagulation/fibrinolysis markers in patients with coronary heart disease (CHD) and concomitant type 2 diabetes mellitus (DM) and to compare these indices with respect to microvascular ...
Yu.A. Zolotukhina
doaj   +1 more source

Fibrinolytic Status and Risk of Death After Acute Pulmonary Embolism

Clinical and Applied Thrombosis/Hemostasis, 2023
Background Acute pulmonary embolism (PE) is a heterogeneous disease process with variable presentation and outcomes. The endogenous fibrinolytic system is a complex framework of regulatory pathways that maintains homeostasis by dissolving overabundant ...
Yevgeniy Brailovsky DO, MSc, Vladimir Lakhter DO, Joshua Newman MD, Sorcha Allen MBBCh, Ahmed Elkaryoni MD, Parth Desai MD, Dalila Masic PharmD, Carlos F. Bechara MD, Emily Bontekoe BS, Debra Hoppensteadt PhD, John J. Lopez MD, Fakiha Siddiqui BDS, Omer Iqbal PhD, Jawed Fareed PhD, Amir Darki, MD, MSc   +14 more
doaj   +1 more source

Fibrinolytic system of guinea pig serum

, 1959
Comparative studies on 10 mammals showed that, in contrast to all the others, guinea pig serum alone, on precipitation with acetic acid, pH 5.3–5.4 at 4°C, yielded a euglobulin with high spontaneous fibrinolytic activity.
Zbigniew Latallo, Stefan Niewiarowski, Alfred L. Copley   +2 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Prediction of Failed Fibrinolytic Using Scoring System in ST Elevation Myocardial Infarction Patients

, 2017
Background: ST elevation myocardial infarction (STEMI) is the most common acute coronary syndrome in adults, and requiring immediate reperfusion. Primary percutaneous coronary intervention (PCI) is the main reperfusion therapy, but because of many ...
Hariawan, Hariadi, Mahendra, Satria, Setianto, Budi Yuli   +2 more
core   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source