Fibrinolytic system - Open Access .click

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Perioperative hyperfibrinolysis – physiology and pathophysiology

Brazilian Journal of Anesthesiology, 2021
Introduction and objectives: The role of the anesthesiologist in the perioperative management of hemostasis has attracted increasing attention. The fibrinolytic system participates in hemostasis, removing clots after repair of the vascular injury.
David Silveira Marinho
doaj +1 more source

Higher Complement C4 Gene Copy Number Constitutes a Shared Genetic Risk Factor for Giant Cell Arteritis and IgA Vasculitis

Arthritis &Rheumatology, EarlyView.
Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez +295 more
wiley +1 more source

Independence of activation of the fibrinolytic system from certain immunologic systems

, 1959
Activation of the immunologic system either in vitro or in vivo results in nearly complete consumption of complement without activation of the fibrinolytic system. However complement activity decreased upon the induction of fibrinolytic activity even in
S. N. Kolmen, D. R. Celander, M. Mason Guest +2 more
core +1 more source

Hypoxic hypoxia as a haemostatic system-activating factor

Бюллетень сибирской медицины, 2007
Aimed at investigating influence of hypoxic hypoxia of different duration on haemostatic system state, the assessment of coagulogram in 152 Vistar rats 1 and 3 hours after single «lifting» to the height of 5500 m over sea level in pressure chamber and ...
I. I. Shakhmatov +4 more
doaj +1 more source

Cangrelor Dosing, Administration, and Clinical Outcomes for Patients Undergoing Complex and High‐Risk Percutaneous Coronary Interventions

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Cangrelor reduces thrombotic events in patients undergoing percutaneous coronary intervention (PCI), with the advantage of rapid onset and offset. However, premature discontinuation may increase the risk of acute thrombosis for patients undergoing complex/high‐risk PCI (CHIP).
Siyu Ma +8 more
wiley +1 more source

The Impact of the Fibrinolytic System on the Immune Response in Mice and Humans

, 2018
The fibrinolytic system is well known for its role in clot dissolution, but has more recently been demonstrated to also impact on the immune system. This thesis provides evidence for the involvement of the fibrinolytic system in the immune response after
DOMINIK FERDINAND DRAXLER (5025563)
core +1 more source

A Contemporary Review of Plasminogen Activator Inhibitor Type 1: Structure, Function, Genetic Architecture, and Intracellular/Extracellular Roles

TH Open
Plasminogen activator inhibitor type 1 (PAI-1) is the key regulator of the fibrinolytic system, thereby acting as a potent mediator in thrombosis. Plasminogen activators such as PAI-1 mediate the conversion of the inactive zymogen plasminogen to plasmin,
Jacob Wortley +4 more
doaj +1 more source

Pharmacoinvasive Strategy in Acute STEMI

Majalah Kardiologi Indonesia, 2013
Recently, primary percutaneous coronary intervention (PCI) is the best option for reperfusion in STEMI patients, in clinical trials has lower rates of reinfarction, stroke and mortality than fibrinolytic therapy.
Isman Firdaus
doaj +1 more source

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu +9 more
wiley +1 more source

A Fibrinolytic System in Human iMilk.

Experimental Biology and Medicine, 1953
Summary1. Human milk contains varying amounts of an agent, which activates plasminogen to plasmin. 2. Human milk contains considerable amounts of a proactivator, which by addition of streptokinase is transformed into an activator of plasminogen.
T, ASTRUP, I, STERNDORFF
openaire +2 more sources

fibrinolysis
plasminogen activator inhibitor-1
pai-1

plasminogen
thrombosis
plasmin

hemostasis