Results 11 to 20 of about 75,068 (195)

Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications

Frontiers in Oncology, 2018
The plasminogen activator (PA) system is an extracellular proteolytic enzyme system associated with various physiological and pathophysiological processes.
Niaz Mahmood, Catalin Mihalcioiu, Shafaat A. Rabbani, Shafaat A. Rabbani   +3 more
doaj   +1 more source

Clinical significance of measuring plasminogen activator inhibitor-1 in sepsis

Journal of Intensive Care, 2017
Background Disseminated thrombotic process in the microcirculation is considered to be an important cause of multiple organ dysfunction in sepsis.
Toshiaki Iba, Jecko Thachil
doaj   +1 more source

The Role of Clock Genes in Fibrinolysis Regulation: Circadian Disturbance and Its Effect on Fibrinolytic Activity

Frontiers in Physiology, 2020
The fibrinolytic system is critical during the onset of fibrinolysis, a fundamental mechanism for fibrin degradation. Both tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) trigger fibrinolysis, leading to proteolytic ...
Pamela Carmona, Pamela Carmona, Pamela Carmona, Natalia Mendez, Carmen G. Ili, Carmen G. Ili, Priscilla Brebi, Priscilla Brebi   +7 more
doaj   +1 more source

Tissue plasminogen activator is a ligand of cation-independent mannose 6-phosphate receptor and consists of glycoforms that contain mannose 6-phosphate

Scientific Reports, 2021
Plasmin is the key enzyme in fibrinolysis. Upon interaction with plasminogen activators, the zymogen plasminogen is converted to active plasmin. Some studies indicate plasminogen activation is regulated by cation-independent mannose 6-phosphate receptor (
James J. Miller, Richard N. Bohnsack, Linda J. Olson, Mayumi Ishihara, Kazuhiro Aoki, Michael Tiemeyer, Nancy M. Dahms   +6 more
doaj   +1 more source

Expression of the plasminogen system in the physiological mouse ovary and in the pathological polycystic ovary syndrome (PCOS) state

Reproductive Biology and Endocrinology, 2019
Background The fibrinolytic system and its inhibitors play a number of roles, apart from their function in blood haemostasis and thrombosis, namely in ovarian folliculogenesis and in ovulation.
Genia F. Burchall, Dodie S. Pouniotis, Helena J. Teede, Sanjeeva Ranasinha, Kirsty A. Walters, Terrence J. Piva   +5 more
doaj   +1 more source

Components of the plasminogen activation system promote engraftment of porous polyethylene biomaterial via common and distinct effects. [PDF]

PLoS ONE, 2015
Rapid fibrovascularization is a prerequisite for successful biomaterial engraftment. In addition to their well-known roles in fibrinolysis, urokinase-type plasminogen activator (uPA) and tissue plasminogen activator (tPA) or their inhibitor plasminogen ...
Christoph A Reichel, Maximilian E T Hessenauer, Kerstin Pflieger, Markus Rehberg, Sandip M Kanse, Stefan Zahler, Fritz Krombach, Alexander Berghaus, Sebastian Strieth   +8 more
doaj   +1 more source

Role of flow cytometry in multiple myeloma and the prognostic significance of CD87 (uPAR) expression

Turkish Journal of Hematology, 2010
Objective: The plasminogen activator system consists of the serine protease urokinase plasminogen activator (uPA), two endogenous inhibitors of PAI-1 (plasminogen activator inhibitor-1) as well as the PAI-2 and uPA receptor (uPAR or CD87).
Murat Albayrak, Özlem Şahin Balçık, Simten Dağdaş, Mesude Yılmaz, Funda Ceran, Osman Yokuş, Gülsüm Özet   +6 more
doaj   +3 more sources

Decrease of fibrinolytic potential in the occurrence of cerebral ischemia [PDF]

Journal of Medical Biochemistry, 2008
One of the most present clinical manifestations of long and progressive atherothrombotic occurrences is the ischemic cerebrovascular insult, one of the leading causes of death and illness in the world.
Vučković Biljana, Đerić Mirjana, Ilić Tatjana, Čanak Višnja, Žarkov Marija   +4 more
doaj  

A Serpin With a Finger in Many PAIs: PAI-1's Central Function in Thromboinflammation and Cardiovascular Disease

Frontiers in Cardiovascular Medicine, 2021
Plasminogen activator inhibitor 1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily. PAI-1 is the principal inhibitor of the plasminogen activators, tissue plasminogen activator (tPA), and urokinase-type plasminogen activator (uPA)
Gael B. Morrow, Gael B. Morrow, Claire S. Whyte, Nicola J. Mutch   +3 more
doaj   +1 more source

The plasminogen activating system in the pathogenesis of Alzheimer’s disease

Neural Regeneration Research, 2021
Dementia is a clinical syndrome that affects approximately 47 million people worldwide and is characterized by progressive and irreversible decline of cognitive, behavioral and sesorimotor functions. Alzheimer’s disease (AD) accounts for approximately 60–
Manuel Yepes
doaj   +1 more source