Results 21 to 30 of about 75,068 (195)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury. [PDF]

PLoS ONE, 2013
BACKGROUND: Critically ill patients frequently develop acute lung injury (ALI). Disturbed alveolar fibrin turnover, a characteristic feature of ALI, is the result of both activation of coagulation and inhibition of fibrinolysis.
Jorrit J Hofstra, Alexander D Cornet, Paul J Declerck, Barry Dixon, Hamid Aslami, Alexander P J Vlaar, Joris J Roelofs, Tom van der Poll, Marcel Levi, Marcus J Schultz   +9 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Proteolytic enzyme and adiponectin receptors as potential targets for COVID-19 therapy

Кардиоваскулярная терапия и профилактика, 2021
The coronavirus disease 2019 (COVID-19) pandemic requires not only the creation of vaccines to prevent the spread of the disease, but also the development of novel drugs aimed at reducing viral load, suppressing an excessive immune response and ...
K. A. Rubina, N. R. Sabitova, A. Yu. Efimenko, N. I. Kalinina, J. A. Akopyan, E. V. Semina   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Relationship Between Severity of Fibrinolysis Based on Rotational Thromboelastometry and Conventional Fibrinolysis Markers

Clinical and Applied Thrombosis/Hemostasis, 2020
The association between severity of fibrinolysis, ascertained by rotational thromboelastometry to diagnose hyperfibrinolysis in patients with out-of-hospital cardiac arrest (OHCA), and conventional fibrinolysis markers (ie, tissue-plasminogen activator ...
Tomoyo Saito MD, PhD, Mineji Hayakawa MD, PhD, Yoshinori Honma MD, Asumi Mizugaki MD, Tomonao Yoshida MD, Kenichi Katabami MD, Takeshi Wada MD, PhD, Kunihiko Maekawa MD   +7 more
doaj   +1 more source

The role of the fibrinolytic system in female reproductive disorders and depression

Thrombosis Update, 2020
Tissue plasminogen activator (tPA) and urinary plasminogen activator (uPA or urokinase) have important functions in the extracellular matrix. In the reproductive system, for example, tPA and uPA mediate tissue remodeling required for ovulation ...
Silvia Hoirisch-Clapauch, Benjamin Brenner   +1 more
doaj   +1 more source

Intracranial hemorrhage after recombinant tissue plasminogen Activator: The competing risks survival analysis

Interdisciplinary Neurosurgery, 2023
Intravenous recombination of tissue plasminogen activator is a recommended treatment for patients with ischemic stroke. However, its side effects are associated with an increased risk of intracerebral hemorrhage.
Waitayaporn Pengtong, Natnaree Aimyong, Yongchai Nilanont   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The Roles of Fibrinolytic Factors in Bone Destruction Caused by Inflammation

Cells
Chronic inflammatory diseases, such as rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, Crohn’s disease, periodontitis, and carcinoma metastasis frequently result in bone destruction.
Yosuke Kanno
doaj   +1 more source