Results 141 to 150 of about 91,776 (288)

Maternal Obesity Is Associated With Adverse Pregnancy Outcomes in Inflammatory Bowel Disease: A Matched Electronic Health Record Cohort Study

Alimentary Pharmacology &Therapeutics, EarlyView.
More than one in five pregnancies in women with IBD were complicated by obesity. Obesity was strongly associated with adverse pregnancy outcomes, whereas this study did not identify a significant additional effect attributable to IBD diagnosis alone.
Christopher Roberts, Rebecca Smith, Safwat Odeh, Nathan Kuk, Ayushi Chauhan, Claire Bewshea, Vida Cairnes, Hayley Toll, Nick Kennedy, James Goodhand, Tariq Ahmad, Jennifer Blackman, Alex Bain, Sally Bell, Jennie Clough   +14 more
wiley   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

Biochemical and structural analyses suggest that plasminogen activators coevolved with their cognate protein substrates and inhibitors. [PDF]

J Biol Chem, 2019
Jendroszek A, Madsen JB, Chana-Muñoz A, Dupont DM, Christensen A, Panitz F, Füchtbauer EM, Lovell SC, Jensen JK.   +8 more
europepmc   +1 more source

Emerging insights into amino acid metabolism in the heart: implications for cardiovascular diseases and therapeutic targeting

British Journal of Pharmacology, EarlyView.
As a metabolically versatile organ, the heart is capable of generating energy from a wide range of substrates. Although fatty acid and glucose metabolism in the heart have been extensively studied, the contribution of amino acid metabolism to cardiac physiology and disease is gaining increasing attention.
Tayyiba Azam, Hongyuan Zhang, Min Zi, Chen Chen, Junfang Wu, Andreas Papapetropoulos, Xin Wang   +6 more
wiley   +1 more source

Uniqueness of plasminogen activators [PDF]

Nature, 1976
J K, Christman, G, Acs
openaire   +2 more sources

Interfering factors in the assay of plasminogen activators by the fibrin plate method : Occurrence of different inhibitors against tissue plasminogen activator and urokinase

, 1979
The assay of plasminogen activator activities on fibrin plates was re-evaluated with special reference to fibrinolysis inhibitors present in samples and in fibrin plates.
Wijngaards, G.
core  

Highly potent, brain‐penetrant EP2 receptor antagonists for the treatment of permanent focal cerebral ischaemia in male and female mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Cerebral ischaemia is a leading cause of death in older adults and imposes a substantial global economic burden. Recent studies indicate that inhibiting the Gαs‐coupled EP2 receptor reduces ischaemic brain injury by modulating neuroinflammation.
Zhen Jin, Chenyao Jiang, Eun Bee Cho, M. Dennis Leo, Jiukuan Hao, Jiawang Liu, Ying Yu, Jianxiong Jiang   +7 more
wiley   +1 more source

Effects of Progesterone and 17β-Estradiol under Presence or Absence of FBS on Plasminogen Activators Activity in Porcine Uterine Epithelial Cells. [PDF]

Dev Reprod, 2018
Hwangbo Y, Lee MR, Cheong HT, Yang BK, Park CK.   +4 more
europepmc   +1 more source

Treatment‐Free Remission in Chronic Myeloid Leukemia: Toward Precision and Personalized Approaches to Functional Cure

Cancer Science, EarlyView.
Immune surveillance of residual leukemic stem cells after tyrosine kinase inhibitor discontinuation involves coordinated NK‐cell, CTL, Treg, pDC, and neutrophil activity that predicts treatment‐free remission, while exhausted CTLs and Treg expansion predict relapse in chronic myeloid leukemia.
Hiroshi Ureshino, Shinya Kimura
wiley   +1 more source