Results 131 to 140 of about 91,776 (288)

Immunomodulatory effects of plasminogen activators on hepatic fibrogenesis

, 2008
Summary Tissue-type plasminogen activators (tPA) and urokinase-type plasminogen activators (uPA) are involved in liver repair. We examined the potential immunomodulatory actions of uPA, tPA and uPA-receptor (uPAR) in carbon-tetrachloride ...
A Melhem, O Pappo, S L Friedman, A Horani, N Muhanna, A A Higazi, C E Alvarez, M El-Haj, R Safadi   +8 more
core   +1 more source

Peritoneal Fluid‐Derived Small Extracellular Vesicle Proteins as Potential Biomarkers for Endometriosis: A Case–Control Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To demonstrate the presence of peritoneal fluid (PF)‐derived small extracellular vesicles (sEVs) in endometriosis and control samples, to characterise their protein content and to define endometriosis‐specific biomarkers within the sEV proteome. Design Case–control experimental study. Setting Academic endometriosis centre.
Hannah M. Nazri, Roman Fischer, Joel Steele, Sanjiv Manek, Kavita S. Subramaniam, Benedikt M. Kessler, Krina T. Zondervan, Thomas T. Tapmeier, Christian M. Becker   +8 more
wiley   +1 more source

Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation

Integrative Zoology, EarlyView.
Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv, Wanfei Deng, Fei Deng, Shixia Xu, Wenhua Ren   +4 more
wiley   +1 more source

Regulation of the synthesis and secretion of plasminogen activators by endothelial cells

, 1988
Plasminogen activators (PAs) play a role in fibrinolysis, tissue remodelling, tumor invasion, and reparative processes. Vascular endothelial cells produce tissue-type PA (t-PA), an important regulator of fibrinolysis, and PA inhibitor 1.
Hinsbergh, V.W.M. van
core  

The Lymphatic System as Contributor of Plasminogen Activator to the Blood

, 1970
It is suggested that the lymphatic system through the chyle contributes plasminogen activators to the circulating blood.
D. Weightman, Sudhakaran Menon, H.A. Dewar   +2 more
core   +1 more source

Substrate specificity of tissue-type and urokinase-type plasminogen activators

, 1991
Recent studies suggest that plasminogen activators not only hydrolyse a specific arginine-valine bond in plasminogen, but may also cleave other proteins such as fibronectin.
Groeneveld, E., Rijken, D.C.
core  

Plasminogen Activator Inhibitor 1: Physiological and Pathophysiological Roles

, 2002
Plasminogen activator inhibitor 1 (PAI-1) inhibits plasminogen activators (u-PA and t-PA) by forming stable complexes endocytosed via a low-density lipoprotein receptor superfamily member-dependent mechanism.
Nelly Grubic, Judit Mihaly, Bernd R. Binder, Michael Krebs, Günter Christ, Peter Hufnagl, Gerald W. Prager, Florian Gruber   +7 more
core   +1 more source

Seminal Biomarkers and Sperm Proteomic Signatures Differentiate Acute and Chronic Male Accessory Gland Inflammation

Andrology, EarlyView.
ABSTRACT Background Male accessory gland inflammation (MAGI) comprises a heterogeneous group of inflammatory conditions that may differentially affect the seminal microenvironment and sperm function. However, whether transrectal ultrasound (TRUS)‐defined MAGI phenotypes correspond to distinct biological profiles remains insufficiently characterized ...
Emanuela Teveroni, Fiorella Di Nicuolo, Giorgia Mazzuccato, Alessandro Oliva, Emanuele Pierpaolo Vodola, Francesca Mancini, Carla Di Nardo, Edoardo Vergani, Michela Cicchinelli, Federica Iavarone, Cassandra Serantoni, Giuseppe Maulucci, Alessia Riente, Alfredo Pontecorvi, Andrea Urbani, Domenico Milardi, Silvia Baroni   +16 more
wiley   +1 more source

Pulmonary Embolism—A Century of Progress

ANZ Journal of Surgery, EarlyView.
Reviews a century of progress in the diagnosis, prevention, and management of pulmonary embolism; from the first successful surgical embolectomy in 1924 to advanced imaging, pharmacological thromboprophylaxis, and treatment. In the 21st century, advances include catheter‐directed thrombolysis or mechanical thrombectomy under decision‐making guidance of
D. A. Watters
wiley   +1 more source

Transcranial Histotripsy Clot and Tissue Ablation for Intracerebral Hemorrhage Evacuation and Other Brain Applications

, 2023
STROKE: Vascular and Interventional Neurology, EarlyView.
Jonathan Sukovich, Zhen Xu, Aditya S. Pandey   +2 more
wiley   +1 more source