Results 41 to 50 of about 3,326,153 (390)
Interaction with human plasminogen system turns on proteolytic activity in Streptococcus agalactiae and enhances its virulence in a mouse model [PDF]
, 2001 Interactions of several microbial pathogens with the plasminogen system increase their invasive potential. In this study, we show that Streptococcus agalactiae binds human plasminogen which can be subsequently activated to plasmin, thus generating a ...
Vanessa Magalhaes +6 more
core +4 more sources
Purification and properties of plasminogen activators from epithelial cells.
European Journal of Biochemistry, 2008 Two epithelial plasminogen activators were purified from the serum-free conditioned medium of guinea pig keratocytes (GPK) and human breast epithelial (BEB) cells in culture.
A. Electricwala, T. Atkinson
semanticscholar +1 more source
Pathogen activators of plasminogen [PDF]
Journal of Thrombosis and Haemostasis, 2015 Group A streptococci (GAS) express soluble and surface-bound virulence factors. Secreted streptokinase (SK) allelic variants exhibit varying abilities to activate host plasminogen (Pg), and GAS pathogenicity is associated with Pg activation and localization of the resulting plasmin (Pm) on the bacterial surface to promote dissemination.
Paul E. Bock +2 more
openaire +3 more sources
Spectrophotometric analysis of thrombolytic activity: SATA assay [PDF]
, 2017 Introduction: Measurement of thrombolytic activity i.e. clot lysis is crucial for research and development of novel thrombolytics. It is also a key factor in assessment of the effectiveness of conventionally used thrombolytic agents in the clinic, which ...
Entekhabi, Nazila +5 more
core +2 more sources
Roles and regulation of membrane-associated serine proteases [PDF]
, 2007 Pericellular proteolytic activity affects many aspects of cellular behaviour, via mechanisms involving processing of the extracellular matrix, growth factors and receptors.
Bass, Rosemary +4 more
core +1 more source
Brazilian Journal of Medical and Biological Research, 1997 We cloned the streptokinase (STK) gene of Streptococcus equisimilis in an expression vector of Escherichia coli to overexpress the profibrinolytic protein under the control of a tac promoter. Almost all the recombinant STK was exported to the periplasmic
L. Avilán +5 more
doaj +1 more source
Mice deficient in urokinase-type plasminogen activator have delayed healing of tympanic membrane perforations. [PDF]
PLoS ONE, 2012 Mice deficient in plasminogen, the precursor of plasmin, show completely arrested healing of tympanic membrane (TM) perforations, indicating that plasmin plays an essential role in TM healing.
Yue Shen +5 more
doaj +1 more source
Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury. [PDF]
, 2009 PurposeDeposition of fibrin in the alveolar space is a hallmark of acute lung injury (ALI). Plasminogen activator inhibitor-1 (PAI-1) is an antifibrinolytic agent that is activated during inflammation. Increased plasma and pulmonary edema fluid levels of
Brady, Sandra +4 more
core +2 more sources
Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones [PDF]
, 2013 Neutrophil extracellular traps are networks of DNA and associated proteins produced by nucleosome release from activated neutrophils in response to infection stimuli and have recently been identified as key mediators between innate immunity, inflammation,
Ammollo +36 more
core +1 more source
Brazilian Journal of Medical and Biological Research, 2000 The interaction of plasminogen, tissue plasminogen activator (t-PA) and urokinase with a clinical strain of Helicobacter pylori was studied. Plasminogen bound to the surface of H. pylori cells in a concentration-dependent manner and could be activated to
A. Yarzábal +5 more
doaj +1 more source