Results 41 to 50 of about 54,262 (254)

Mice deficient in urokinase-type plasminogen activator have delayed healing of tympanic membrane perforations. [PDF]

PLoS ONE, 2012
Mice deficient in plasminogen, the precursor of plasmin, show completely arrested healing of tympanic membrane (TM) perforations, indicating that plasmin plays an essential role in TM healing.
Yue Shen, Yongzhi Guo, Chun Du, Malgorzata Wilczynska, Sten Hellström, Tor Ny   +5 more
doaj   +1 more source

MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients. [PDF]

, 2012
BackgroundUpregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients.MethodsWe assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in ...
Hardwick, JCH, Hawinkels, LJAC, Hommes, DW, Kubben, FJGM, Langers, AMJ, Sier, CFM, van der Reijden, JJ, van Duijn, W, Verspaget, HW   +8 more
core   +1 more source

A study of the interaction between Helicobacter pylori and components of the human fibrinolytic system

Brazilian Journal of Medical and Biological Research, 2000
The interaction of plasminogen, tissue plasminogen activator (t-PA) and urokinase with a clinical strain of Helicobacter pylori was studied. Plasminogen bound to the surface of H. pylori cells in a concentration-dependent manner and could be activated to
A. Yarzábal, L. Avilán, K. Hoelzl, M. de Muñoz, J. Puig, I. Kansau   +5 more
doaj   +1 more source

Cloning, expression and purification of recombinant streptokinase: partial characterization of the protein expressed in Escherichia coli

Brazilian Journal of Medical and Biological Research, 1997
We cloned the streptokinase (STK) gene of Streptococcus equisimilis in an expression vector of Escherichia coli to overexpress the profibrinolytic protein under the control of a tac promoter. Almost all the recombinant STK was exported to the periplasmic
L. Avilán, A. Yarzábal, C. Jürgensen, M. Bastidas, J. Cruz, J. Puig   +5 more
doaj   +1 more source

Coagulation and anticoagulation in idiopathic pulmonary fibrosis [PDF]

, 2015
Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive interstitial lung disease with a prognosis that is worse than that of many cancers. Epidemiological studies have demonstrated a link between IPF and thrombotic vascular events.
Crooks, Michael G., Hart, Simon P.
core   +3 more sources

Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses [PDF]

, 2020
The signalling pathways initiated by members of the transforming growth factor-β (TGFβ) family of cytokines control many metazoan cellular processes, including proliferation and differentiation, epithelial-mesenchymal transition (EMT) and apoptosis. TGFβ
A Rojas-Fernandez, A Woods, AR Ramjaun, AY Hsing, B Bierie, B Ozdamar, B-C Kim, BR Binder, C Allan, CJ David, CS Hill, DB Shackelford, EC Connolly, FA Ran, G Avery-Cooper, G Rena, G Rosti, GD Cuny, GJ Inman, GJ Inman, GM Keating, H Ikushima, J Massagué, J Massagué, J Massaous, J Ozanne, J Song, J Vogt, J Xu, JF Callahan, JL Wrana, JM Lizcano, Joan Massagué, JY Altarejos, K Clark, KA Brown, KJ Livak, LC Spender, LC Spender, M Abe, M Kowanetz, M Tojo, MO Li, MR Keeton, NJ Bright, P Lönn, PH Lin, PK Datta, PM Siegel, RJ Akhurst, RJ Akhurst, S DaCosta Byfield, S Dennler, S Edlund, S Strickson, SA Hawley, T Sonntag, TB Sundberg, Y Drabsch, Y Liu, Y Shi, Y Yang, Y Zhang, Y Zhang   +63 more
core   +2 more sources

Indicators of the fibrinolytic system in the blood and cerebrospinal fluid of patients with metastatic brain lesions

Опухоли головы и шеи
Introduction. Brain metastases – the most common type of intracranial secondary neoplasms in adults – are characterized by high mortality and are the main cause of death in almost 1/5 of all oncological patients.
L. A. Goroshinskaya, I. V. Kaplieva, A. A. Babasinov, E. E. Rostorguev, Yu. A. Petrova, L. K. Trepitaki, A. V. Snezhko, S. G. Vlasov   +7 more
doaj   +1 more source

The plasmin-antiplasmin system: structural and functional aspects [PDF]

, 2018
The plasmin-antiplasmin system plays a key role in blood coagulation and fibrinolysis. Plasmin and α2-antiplasmin are primarily responsible for a controlled and regulated dissolution of the fibrin polymers into soluble fragments. However, besides plasmin(
Gerber, Simon, Schaller, Johann
core  

Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]

, 2003
Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R., Braungart, E., Degitz, K., Douwes, K., Flaig, M. J., Magdolen, V., Probst, C., Sander, C. A., Schuh, T., Wosikowski, K.   +9 more
core   +1 more source

Characterization of plasmin, plasminogen and plasminogen activator in goat milk

Italian Journal of Animal Science, 2011
Plasmin (PL), a serine-proteinase, appears to be the predominant native proteinase in milk and it is mainly associated to casein micelles which represent its substrate (Bastian and Brown, 1996). Plasmin occurs in milk together with its inactive zymogene,
F. Polidori, G. Lebbroni, P. Polidori, F. Fantuz   +3 more
doaj   +1 more source