Results 81 to 90 of about 3,326,153 (390)

The Axonally Secreted Serine Proteinase Inhibitor, Neuroserpin, Inhibits Plasminogen Activators and Plasmin but Not Thrombin*

Journal of Biological Chemistry, 1998
Neuroserpin is an axonally secreted serine proteinase inhibitor that is expressed in neurons during embryogenesis and in the adult nervous system. To identify target proteinases, we used a eucaryotic expression system based on the mouse myeloma cell line
Thomas Osterwalder, P. Cinelli, A. Baici, Amedea Pennella, S. Krueger, S. Schrimpf, M. Meins, P. Sonderegger   +7 more
semanticscholar   +1 more source

Methodological factors influencing measurement and processing of plasma reelin in humans [PDF]

, 2003
BACKGROUND: Reelin, intensively studied as an extracellular protein that regulates brain development, is also expressed in a variety of tissues and a circulating pool of reelin exists in adult mammals.
Davis, John M, Keller, Flavio, Krueger, Jacqueline M, Lugli, Giovanni, Persico, Antonio M, Smalheiser, Neil R   +5 more
core   +3 more sources

Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis

Advanced Science, EarlyView.
In this study, a mechanical biomimetic nanocomposite is developed, guided by photoacoustic imaging, to achieve highly efficient and safe thrombolysis through the synergistic effects of photothermal therapy and pharmacological intervention. Most notably, the nanoparticle improves the microenvironment of arterial thrombi, marked by high shear stress and ...
Ying Li, Qi Xiang, Yan Zhang, Fuxue Luo, Yunfang Wu, Haitao Ran, Yang Cao   +6 more
wiley   +1 more source

Relationship Between Language Preference and Intravenous Thrombolysis Among Acute Ischemic Stroke Patients

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundApproximately 20% of the US population primarily speaks a language other than English at home. Yet the effect of language preference on treatment of acute ischemic stroke (AIS) patients remains unknown.
Betty Luan Erfe, Khawja Ahmeruddin Siddiqui, Lee H. Schwamm, Nicte I. Mejia   +3 more
doaj   +1 more source

Immunohistochemical localization of urokinase- and tissue-type plasminogen activators in psoriatic skin.

Journal of Investigative Dermatology, 1987
Biopsies of involved and uninvolved skin from psoriatic patients and of normal skin were stained immunocytochemically with monoclonal antibodies against urokinase-type (u-PA) and tissue-type (t-PA) plasminogen activator using a multilayer peroxidase ...
J. Grøndahl-Hansen, E. Ralfkiaer, L. Nielsen, P. Kristensen, G. Frentz, K. Danø   +5 more
semanticscholar   +1 more source

Colorectal Cancer Cells–Derived Exosomal PIK3CA Mutation DNA Promotes Tumor Metastasis by Activating Fibroblast and Affecting Tumor Metastatic Microenvironment

Advanced Science, EarlyView.
PIK3CAH1047R DNA in colorectal cancer (CRC) cell‐derived exosomes can be delivered into recipient fibroblasts, where it is transcribed and translated, leading to the activation of fibroblasts into cancer‐associated fibroblasts, which secrete elevated levels of IL6. The simultaneous detection and targeting of PIK3CAH1047R mutation and IL6 may serve as a
Rui Wang, Wanming Li, Yuqiong Lv, Wei Ba, Ying Jiang, Xiaoshuai Li, Jin Fang   +6 more
wiley   +1 more source

Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator

Clinical and Translational Medicine, 2018
Background Airway fibrin casts are clinically important complications of severe inhalational smoke-induced acute lung injury (ISIALI) for which reliable evidence-based therapy is lacking.
Satoshi Fukuda, Perenlei Enkhbaatar, Christina Nelson, Robert A. Cox, Marla R. Wolfson, Thomas H. Shaffer, Robert O. Williams, Soraya Hengsawas Surasarang, Sahakijpijarn Sawittree, Galina Florova, Andrey A. Komissarov, Kathleen Koenig, Krishna Sarva, Harrison T. Ndetan, Karan P. Singh, Steven Idell   +15 more
doaj   +1 more source

Cyclic RGD functionalized PLGA nanoparticles loaded with noncovalent complex of indocyanine green with urokinase for synergistic thrombolysis

Frontiers in Bioengineering and Biotechnology, 2022
Thrombotic diseases have the characteristics of long latency period, rapid onset, and high mortality rate, which seriously threaten people’s life and health. The aim of this research is to fabricate a novel indocyanine green complex of urokinase (ICG@uPA)
Sha Zhang, Sha Zhang, Jinjie Li, Jiefeng Ren, Jiefeng Ren, Zaiyao Xue, Zaiyao Xue, Xinlian Qi, Xinlian Qi, Quanjin Si   +9 more
doaj   +1 more source

Plasminogen–receptor KT: plasminogen activation and beyond [PDF]

Journal of Thrombosis and Haemostasis, 2017
The cell surface orchestrates plasminogen activation through the concomitant binding of plasminogen and plasminogen activators to specific receptors. In this issue, Miles and colleagues describe their detailed phenotypic characterization of mice deficient in Plg-RKT, a key plasminogen receptor expressed in numerous tissues, but highly expressed by ...
Matthew J. Flick, Thomas H. Bugge
openaire   +3 more sources

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source