Results 1 to 10 of about 358 (110)
Fibrinolysis and bleeding of unknown cause [PDF]
Research and Practice in Thrombosis and Haemostasis, 2021 Patients with bleeding of unknown cause (BUC) present with a variety of mild to moderate bleeding symptoms, but no hemostatic abnormalities can be found. Hyperfibrinolysis is rarely evaluated as the underlying cause for bleeding in clinical practice, and
Dino Mehic +3 more
doaj +3 more sources
Introduction to paraoxonases. [PDF]
J Lipids, 2012 Journal of Lipids, Volume 2012, Issue 1, 2012.
Aviram M.
europepmc +2 more sources
Novel bis-arylsulfonamides and aryl sulfonimides as inactivators of plasminogen activator inhibitor-1 (PAI-1). [PDF]
Bioorg Med Chem Lett, 2010 Inactivators of plasminogen activator inhibitor-1 (PAI-1) have been identified as possible treatments for a range of conditions, including atherosclerosis, venous thrombosis, and obesity. We describe the synthesis and inhibitory activity of a novel series of compounds based on bis-arylsulfonamide and aryl sulfonimide motifs that show potent and ...
El-Ayache NC +4 more
europepmc +4 more sources
Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1. [PDF]
Proc Natl Acad Sci U S A, 2013 Significance Serine protease inhibitors (serpins) are a protein superfamily whose members are involved in many diseases and are thus attractive drug targets. In addition to protease inhibition, serpins also bind a variety a of other biological molecules, including extracellular matrix components and cell surface receptors.
Li SH +6 more
europepmc +4 more sources
Immunohistochemical study of the plasminogen activator system in benign epithelial odontogenic lesions [PDF]
Brazilian Oral Research, 2022 : The aim of this study was to analyze and compare the immunohistochemical expression of plasminogen activator system (PAS) proteins (uPA, uPAR, and PAI-1) in ameloblastomas (AMBs), odontogenic keratocysts (OKCs), and dental follicles (DFs) representing ...
Carla Samily de Oliveira Costa +4 more
doaj +1 more source
Journal of Clinical Laboratory Analysis, Volume 36, Issue 6, June 2022., 2022 We performed thromboelastography on the whole blood of pregnant women, and then analyzed the data. We found that thromboelastography has a good application prospect in the differential diagnosis of normal pregnancy and pregnancy complications. Abstract Background This observational study aimed to compare the potential application of thromboelastography
Hongyan Zhao +3 more
wiley +1 more source
Molecular analysis of vascular gene expression
Research and Practice in Thrombosis and Haemostasis, Volume 6, Issue 4, May 2022., 2022 Abstract A State of the Art lecture entitled “Molecular Analysis of Vascular Gene Expression” was presented at the ISTH Congress in 2021. Endothelial cells (ECs) form a critical interface between the blood and underlying tissue environment, serving as a reactive barrier to maintain tissue homeostasis. ECs play an important role in not only coagulation,
Martijn A. Van der Ent +2 more
wiley +1 more source
Plasminogen activator inhibitor-1 polymers, induced by inactivating amphipathic organochemical ligands [PDF]
Biochemical Journal, 2003 Negatively charged organochemical inactivators of the anti-proteolytic activity of plasminogen activator inhibitor-1 (PAI-1) convert it to inactive polymers. As investigated by native gel electrophoresis, the size of the PAI-1 polymers ranged from dimers to multimers of more than 20 units.
Pedersen, K.E. +6 more
openaire +4 more sources
Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1 [PDF]
International Journal of Cancer, 1999 Human kallikrein 2 (hK2) is a serine protease expressed predominantly in the prostate which has 80% homology to prostate-specific antigen (PSA). hK2 is an active trypsin-like protease which has been shown by immuno-histochemical staining to be more highly expressed in prostate carcinoma than in benign prostate tissue. Unlike PSA, hK2 activates pro-PSA ,
S D, Mikolajczyk +3 more
openaire +2 more sources
Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins [PDF]
The Journal of Cell Biology, 2003 The binding of urokinase plaminogen activator (uPA) to its cell surface receptor (uPAR; CD87) promotes cell adhesion by increasing the affinity of the receptor for both vitronectin (VN) and integrins. We provide evidence that plasminogen activator inhibitor (PAI)-1 can detach cells by disrupting uPAR–VN and integrin–VN interactions and that it does so ...
Czekay, Ralf-Peter +3 more
openaire +2 more sources